DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4g15 and Cyp4f18

DIOPT Version :9

Sequence 1:	NP_572721.1	Gene:	Cyp4g15 / 32093	FlyBaseID:	FBgn0030304	Length:	574	Species:	Drosophila melanogaster
Sequence 2:	NP_077764.2	Gene:	Cyp4f18 / 72054	MGIID:	1919304	Length:	524	Species:	Mus musculus

Alignment Length:	529	Identity:	149/529 - (28%)
Similarity:	261/529 - (49%)	Gaps:	81/529 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 IVGHLFDVIGPASSV--FRTVIRKSAPFEHIAKMWIGP-KLVVFIYDPRDVE-LLLSSHVYIDKA 114
            |:|||..:......:  .::::|   .|......|:|| ..|:.|:.|..:: ::|:..:...|.
Mouse    60 ILGHLGLIQSSEEGLLYIQSLVR---TFRDACCWWVGPLHPVIRIFHPAFIKPVVLAPALVAPKD 121

  Fly   115 SE-YKFFKPWLGDGLLISTGQKWRSHRKLIAPTFHLNVLKSFIELFNENSRNVV----RKLRAED 174
            :. |:|.|||||||||:|||.||..||:::.|.||.|:||.::::||: |.|::    ::|.::.
Mouse   122 TVFYRFLKPWLGDGLLMSTGDKWSRHRRMLTPAFHFNILKPYVKVFND-STNIMHAKWQRLASKG 185

  Fly   175 GRTFDCHDYMSEATVEILLETAMGVSKKTQDKSGFEYAMAVMRMCDILHARHRSIFLRNEFVFTL 239
            ....:..:::|..|::.|.:.........|:|.. ||..|::.:..::..||:.:.|..:..:.|
Mouse   186 SAYLNMFEHISLMTLDSLQKCVFSFDSNCQEKPS-EYITAILELSTLVARRHQRLLLHVDLFYYL 249

  Fly   240 TRYYKEQGRLLNIIHGLTTKVIRSKKAAFEQGTRGSLAQCELKAAALEREREQNGGVDQTPSTAG 304
            |.......:...::|..|..|||.::                      |.....||||..
Mouse   250 THDGMRFRKACRLVHDFTDAVIRERR----------------------RTLLDQGGVDVL----- 287

  Fly   305 SDEKDREKDKEKASPVAGLSYGQSAGLKDDLDVEDNDIGEKKRLAFLD-LMLESAQNGALITDTE 368
                   |.|.||                            |.|.|:| |:|...::|..::|.:
Mouse   288 -------KAKAKA----------------------------KTLDFIDVLLLSKDEHGKALSDED 317

  Fly   369 IKEQVDTIMFEGHDTTAAGSSFFLSLMGIHQDIQDRVLAELDSIFGDSQ-RPATFQDTLEMKYLE 432
            |:.:.||.||.||||||:|.|:.|..:..|.:.|:|...|:..:..|.: ....:.|..::.:|.
Mouse   318 IRAEADTFMFGGHDTTASGLSWILYNLARHPEYQERCRQEVRELLRDREPEEIEWDDLAQLPFLT 382

  Fly   433 RCLMETLRMYPPVPLIARELQEDLKLNSGNYVIPRGATVTVATVLLHRNPKVYANPNVFDPDNFL 497
            .|:.|:||::|||..|:|...:|:.|..|. |||:|....::....|.||.|:.:|.|:||..|.
Mouse   383 MCIKESLRLHPPVTAISRCCTQDIVLPDGR-VIPKGVISRISIFGTHHNPAVWPDPEVYDPFRFD 446

  Fly   498 PERQANRHYYAFVPFSAGPRSCVGRKYAMLKLKILLSTILRNYRVYSDLTESDFKLQADIILKRE 562
            .:....|...||:|||||||:|:|:.:||.::|:.|:..|..:||..|  :.:.:.:.::||:.|
Mouse   447 ADNVKGRSPLAFIPFSAGPRNCIGQTFAMSEMKVALALTLLRFRVLPD--DKEPRRKPELILRAE 509

  Fly   563 EGFRVRLQP 571
            .|..::::|
Mouse   510 GGLWLKVEP 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4g15	NP_572721.1	p450	47..542	CDD:278495	141/498 (28%)
Cyp4f18	NP_077764.2	p450	52..516	CDD:365848	148/525 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.820