DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4g15 and Cyp4f16

DIOPT Version :9

Sequence 1:	NP_572721.1	Gene:	Cyp4g15 / 32093	FlyBaseID:	FBgn0030304	Length:	574	Species:	Drosophila melanogaster
Sequence 2:	NP_001343232.1	Gene:	Cyp4f16 / 70101	MGIID:	1917351	Length:	524	Species:	Mus musculus

Alignment Length:	583	Identity:	162/583 - (27%)
Similarity:	272/583 - (46%)	Gaps:	96/583 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LGSPSSVFYFLLLPTLVLW----YIYWRLSRAHLYRLAGRL----PGPRGLPIVGHLFDVIGPAS 66
            |||..:..:.|||..:..|    .:.|..|   .|....||    ..|:.....||| .:|....
Mouse    11 LGSVVTSSWHLLLLGVASWILARILAWTYS---FYENCSRLSCFPQPPKKNWFSGHL-GMIQSNE 71

  Fly    67 SVFRTVIRKSAPFEHIAKMWIGPKL-VVFIYDPRDVELLLSSHVYI--DKASEYKFFKPWLGDGL 128
            ...:.|......|:.:...|:||.: |:.|.||..|..||.:...:  ...:..:|.||||||||
Mouse    72 EGMQLVTEMGQTFQDVHLFWLGPVIPVLRIVDPAFVAPLLQAPALVAPKDMTFLRFLKPWLGDGL 136

  Fly   129 LISTGQKWRSHRKLIAPTFHLNVLKSFIELFNENSRNVV----RKLRAEDGRTFDCHDYMSEATV 189
            .:|:|.||..||:|:.|.||.::||.::::||: |.|::    :.|.:|.....:..:::|..|:
Mouse   137 FLSSGDKWSRHRRLLTPAFHFDILKPYVKIFNQ-SVNIMHAKWKHLSSEGSARLEMFEHISLMTL 200

  Fly   190 EILLETAMGVSKKTQDKSGFEYAMAVMRMCDILHARHRSIFLRNEFVFTLTRYYKEQGR----LL 250
            :.|.:...|.....|: |..||..|::.:..::..|...:||..:|::    |:...||    ..
Mouse   201 DSLQKCLFGFDSNCQE-SPSEYISAILELSSLIIKRSLQLFLFVDFLY----YHTADGRRFRKAC 260

  Fly   251 NIIHGLTTKVIRSKKAAFEQGTRGSLAQCELKAAALEREREQNGGVDQTPSTAGSDEKDREKDKE 315
            :::|..|..|||.::                                .|.|:...||..:.|.|.
Mouse   261 DLVHNFTDAVIRERR--------------------------------HTLSSQNHDEFLKSKTKS 293

  Fly   316 KASPVAGLSYGQSAGLKDDLDVEDNDIGEKKRLAFLD-LMLESAQNGALITDTEIKEQVDTIMFE 379
            |.                              |.|:| |:|...::|..::|.:|:.:.||.||.
Mouse   294 KT------------------------------LDFIDVLLLAKDEHGKELSDEDIRAEADTFMFG 328

  Fly   380 GHDTTAAGSSFFLSLMGIHQDIQDRVLAELDSIFGDSQ-RPATFQDTLEMKYLERCLMETLRMYP 443
            ||||||:..|:.|..:..|.:.|:|...|:..:..|.: ....:.|..::.:|..|:.|:||::.
Mouse   329 GHDTTASALSWILYNLARHPEYQERCRQEVQELLRDREPEEIEWDDLAQLPFLTMCIKESLRLHS 393

  Fly   444 PVPLIARELQEDLKLNSGNYVIPRGATVTVATVLLHRNPKVYANPNVFDPDNFLPERQANRHYYA 508
            ||..:.|....|:.|..|. |||:|....::...:|.||.|:.:|.|:||..|.||....|...|
Mouse   394 PVIDLLRRCTRDIVLPDGR-VIPKGNICVISIFGIHHNPSVWPDPEVYDPFRFDPENPQKRSPLA 457

  Fly   509 FVPFSAGPRSCVGRKYAMLKLKILLSTILRNYRVYSDLTESDFKLQADIILKREEGFRVRLQP 571
            |:|||||||:|:|:.:||.::|:.|:..|..:|:..|  :.:.:.:.:|||:.|.|..:|::|
Mouse   458 FIPFSAGPRNCIGQTFAMSEMKVALALTLLRFRILPD--DKEPRRKPEIILRAEGGLWLRVEP 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4g15	NP_572721.1	p450	47..542	CDD:278495	141/507 (28%)
Cyp4f16	NP_001343232.1	p450	52..514	CDD:306555	148/533 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D249473at33208
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.820