Protein Alignment Cyp4g15 and CYP4F12

DIOPT Version :10

• Sequence 1: NP_572721.1
• Gene: Cyp4g15 / 32093
• FlyBaseID: FBgn0030304
• Length: 574
• Species: Drosophila melanogaster
• Sequence 2: NP_076433.3
• Gene: CYP4F12 / 66002
• HGNCID: 18857
• Length: 524
• Species: Homo sapiens
• Alignment Length: 561
• Identity: 163/561 - (29%)
• Similarity: 273/561 - (48%)
• Gaps: 82/561 - (14%)

  Fly    21 LLPTLVLW-YIYWRLSRAHLYRLAGRLPGPRGLPIVGHLFDVIGPASSVFRTVIRKSAPFEHIAK 84
            ||..::.| |.::...|    ||......|:.....||| .:|.|.....:...:.||.:.....
Human    30 LLARILAWTYAFYNNCR----RLQCFPQPPKRNWFWGHL-GLITPTEEGLKNSTQMSATYSQGFT 89

  Fly    85 MWIGPKLVVFIY--DPRDVELLLSSHVYIDKASE--YKFFKPWLGDGLLISTGQKWRSHRKLIAP 145
            :|:|| ::.||.  .|..:..:.::...|.....  .:|.|||||:|:|:|.|.||..||:::.|
Human    90 VWLGP-IIPFIVLCHPDTIRSITNASAAIAPKDNLFIRFLKPWLGEGILLSGGDKWSRHRRMLTP 153

  Fly   146 TFHLNVLKSFIELFNENSRNVVRK---LRAEDGRTFDCHDYMSEATVEILLETAMGVSKKTQDKS 207
            .||.|:|||:|.:||:::..::.|   |.:|.....|..:::|..|::.|.:.........|::.
Human   154 AFHFNILKSYITIFNKSANIMLDKWQHLASEGSSRLDMFEHISLMTLDSLQKCIFSFDSHCQERP 218

  Fly   208 GFEYAMAVMRMCDILHARHRSIFLRNEFVFTLTRYYKEQGRLLNIIHGLTTKVIRSKKAAFEQGT 272
            . ||...::.:..::..|.:.|....:|::.|:...:...|...::|..|..|||
Human   219 S-EYIATILELSALVEKRSQHILQHMDFLYYLSHDGRRFHRACRLVHDFTDAVIR---------- 272

  Fly   273 RGSLAQCELKAAALEREREQNGGVDQTPSTAGSDEKDREKDKEKASPVAGLSYGQSAGLKDDLDV 337
                          ||.|        |..|.|.|  |..|||.|:
Human   273 --------------ERRR--------TLPTQGID--DFFKDKAKS-------------------- 293

  Fly   338 EDNDIGEKKRLAFLD-LMLESAQNGALITDTEIKEQVDTIMFEGHDTTAAGSSFFLSLMGIHQDI 401
                    |.|.|:| |:|...::|..::|.:|:.:.||.||.||||||:|.|:.|..:..|.:.
Human   294 --------KTLDFIDVLLLSKDEDGKALSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEY 350

  Fly   402 QDRVLAELDSIFGD-SQRPATFQDTLEMKYLERCLMETLRMYPPVPLIARELQEDLKLNSGNYVI 465
            |:|...|:..:..| ..:...:.|..::.:|..|:.|:||::||.|.|:|...:|:.|..|. ||
Human   351 QERCRQEVQELLKDRDPKEIEWDDLAQLPFLTMCVKESLRLHPPAPFISRCCTQDIVLPDGR-VI 414

  Fly   466 PRGATVTVATVLLHRNPKVYANPNVFDPDNFLPERQANRHYYAFVPFSAGPRSCVGRKYAMLKLK 530
            |:|.|..:..:.:|.||.|:.:|.|:||..|.||....|...||:|||||||:|:|:.:||.::|
Human   415 PKGITCLIDIIGVHHNPTVWPDPEVYDPFRFDPENSKGRSPLAFIPFSAGPRNCIGQAFAMAEMK 479

  Fly   531 ILLSTILRNYRVYSDLTESDFKLQADIILKREEGFRVRLQP 571
            ::|:.:|.::|...|.||...||  ::|::.|.|..:|::|
Human   480 VVLALMLLHFRFLPDHTEPRRKL--ELIMRAEGGLWLRVEP 518

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4g15	NP_572721.1	CYP4	80..567	CDD:410721	146/495 (29%)
CYP4F12	NP_076433.3	CYP4F	74..515	CDD:410772	148/507 (29%)