DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4g15 and Cyp4f1

DIOPT Version :9

Sequence 1:	NP_572721.1	Gene:	Cyp4g15 / 32093	FlyBaseID:	FBgn0030304	Length:	574	Species:	Drosophila melanogaster
Sequence 2:	NP_062569.2	Gene:	Cyp4f1 / 56266	RGDID:	70926	Length:	524	Species:	Rattus norvegicus

Alignment Length:	573	Identity:	166/573 - (28%)
Similarity:	275/573 - (47%)	Gaps:	100/573 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 TLVLWYIYWRLSRA-----HLYRLAGRLPGPRGLP-------IVGHLFDVIGPASSVFRTVIRKS 76
            ||:|:...|.|::.     ..||...||   ||.|       ::||: .::.|.....:.:.|..
  Rat    21 TLLLFGASWILAQILTQIYAAYRNFRRL---RGFPQPPKRNWLMGHV-GMVTPTEQGLKELTRLV 81

  Fly    77 APFEHIAKMWIGPKLVVFIYDPRDVE---LLLSSHVYIDKASEYKFFKPWLGDGLLISTGQKWRS 138
            ..:.....|||||.:.|......|:.   |..|:.|.:.....|...|||||||||:|.|.||..
  Rat    82 GTYPQGFLMWIGPMVPVITLCHSDIVRSILNASAAVALKDVIFYTILKPWLGDGLLVSAGDKWSR 146

  Fly   139 HRKLIAPTFHLNVLKSFIELFNENSRNVV----RKLRAEDGRTFDCHDYMSEATVEILLETAMGV 199
            ||:::.|.||.|:||.::::||: |.|::    ::|.:|.....|..:::|..|::.|.:.....
  Rat   147 HRRMLTPAFHFNILKPYVKIFND-STNIMHAKWKRLISEGSSRLDMFEHVSLMTLDSLQKCVFSF 210

  Fly   200 SKKTQDKSGFEYAMAVMRMCDILHARHRSIFLRNEFVFTLT----RYYKEQGRLLNIIHGLTTKV 260
            ....|:||. ||..|::.:..::..||:...|..:.::.||    |::|    ..|::|..|..|
  Rat   211 DSNCQEKSS-EYIAAILELSALVAKRHQQPLLFMDLLYNLTPDGMRFHK----ACNLVHEFTDAV 270

  Fly   261 IRSKKAAFEQGTRGSLAQCELKAAALEREREQNGGVDQTPSTAGSDEKDREKDKEKASPVAGLSY 325
            ||                        ||.|        |....|.||..:.|.|.|.
  Rat   271 IR------------------------ERRR--------TLPDQGLDEFLKSKAKSKT-------- 295

  Fly   326 GQSAGLKDDLDVEDNDIGEKKRLAFLD-LMLESAQNGALITDTEIKEQVDTIMFEGHDTTAAGSS 389
                                  |.|:| |:|...::|..::|.:|:.:.||.|||||||||:|.|
  Rat   296 ----------------------LDFIDVLLLTKDEDGKELSDEDIRAEADTFMFEGHDTTASGLS 338

  Fly   390 FFLSLMGIHQDIQDRVLAELDSIFGD-SQRPATFQDTLEMKYLERCLMETLRMYPPVPLIARELQ 453
            :.|..:..|.:.|:|...|:..:..| ......:.|..::.:|..|:.|:||::|||.:|:|...
  Rat   339 WILYNLAKHPEYQERCRQEVQELLRDRDPEEIEWDDLAQLPFLTMCIKESLRLHPPVTVISRCCT 403

  Fly   454 EDLKLNSGNYVIPRGATVTVATVLLHRNPKVYANPNVFDPDNFLPERQANRHYYAFVPFSAGPRS 518
            :|:.|..|. .||:|....::...:|.||.|:.:|.|::|..|.||...:....||:|||||||:
  Rat   404 QDILLPDGR-TIPKGIICLISIFGIHHNPSVWPDPEVYNPFRFDPENIKDSSPLAFIPFSAGPRN 467

  Fly   519 CVGRKYAMLKLKILLSTILRNYRVYSDLTESDFKLQADIILKREEGFRVRLQP 571
            |:|:.:||.::|:.|:..|..:|:..|  :.:.:.|.::||:.|.|..:|::|
  Rat   468 CIGQTFAMSEMKVALALTLLRFRLLPD--DKEPRRQPELILRAEGGLWLRVEP 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4g15	NP_572721.1	p450	47..542	CDD:278495	148/514 (29%)
Cyp4f1	NP_062569.2	CYP4F	74..515	CDD:410772	149/511 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.820