DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4g15 and CYP4F3

DIOPT Version :9

Sequence 1:	NP_572721.1	Gene:	Cyp4g15 / 32093	FlyBaseID:	FBgn0030304	Length:	574	Species:	Drosophila melanogaster
Sequence 2:	NP_000887.2	Gene:	CYP4F3 / 4051	HGNCID:	2646	Length:	520	Species:	Homo sapiens

Alignment Length:	584	Identity:	170/584 - (29%)
Similarity:	279/584 - (47%)	Gaps:	101/584 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 LLLPTLVLWYI-------------YWRLSR--AHLY-------RLAGRLPGPRGLPIVGHLFDVI 62
            |.|.:|.||.:             .|.|:|  |..|       ||......|:....:|||..:.
Human     4 LSLSSLGLWPMAASPWLLLLLVGASWLLARILAWTYTFYDNCCRLRCFPQPPKRNWFLGHLGLIH 68

  Fly    63 GPASSVFRTVIRKSAPFEHIAKMWIGP-KLVVFIYDPRDVELLLSSHVYI---DKASEYKFFKPW 123
            .....:..|. ..:..|..:...|:|| ..:|.|:.|..::.:|.:...|   ||.. |.|.|||
Human    69 SSEEGLLYTQ-SLACTFGDMCCWWVGPWHAIVRIFHPTYIKPVLFAPAAIVPKDKVF-YSFLKPW 131

  Fly   124 LGDGLLISTGQKWRSHRKLIAPTFHLNVLKSFIELFNENSRNVV----RKLRAEDGRTFDCHDYM 184
            ||||||:|.|:||..||:::.|.||.|:||.::::||| |.|::    :.|.:|.....|..:::
Human   132 LGDGLLLSAGEKWSRHRRMLTPAFHFNILKPYMKIFNE-SVNIMHAKWQLLASEGSARLDMFEHI 195

  Fly   185 SEATVEILLETAMGVSKKTQDKSGFEYAMAVMRMCDILHARHRSIFLRNEFVFTLTRYYKEQGRL 249
            |..|::.|.:.........|:|.. ||..|::.:..::..||:.|.|..:|::.||...:...|.
Human   196 SLMTLDSLQKCVFSFDSHCQEKPS-EYIAAILELSALVTKRHQQILLYIDFLYYLTPDGQRFRRA 259

  Fly   250 LNIIHGLTTKVIRSKKAAFEQGTRGSLAQCELKAAALEREREQNGGVDQTPSTAGSDEKDREKDK 314
            ..::|..|..||:                        ||.|        |..:.|.|:..:.|.|
Human   260 CRLVHDFTDAVIQ------------------------ERRR--------TLPSQGVDDFLQAKAK 292

  Fly   315 EKASPVAGLSYGQSAGLKDDLDVEDNDIGEKKRLAFLD-LMLESAQNGALITDTEIKEQVDTIMF 378
            .|.                              |.|:| |:|...::|..::|.:|:.:.||.||
Human   293 SKT------------------------------LDFIDVLLLSKDEDGKKLSDEDIRAEADTFMF 327

  Fly   379 EGHDTTAAGSSFFLSLMGIHQDIQDRVLAELDSIFGDSQ-RPATFQDTLEMKYLERCLMETLRMY 442
            |||||||:|.|:.|..:..|.:.|:|...|:..:..|.: :...:.|..::.:|..|:.|:||::
Human   328 EGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAQLPFLTMCIKESLRLH 392

  Fly   443 PPVPLIARELQEDLKLNSGNYVIPRGATVTVATVLLHRNPKVYANPNVFDPDNFLPERQANRHYY 507
            ||||.::|...:|:.|..|. |||:|....::....|.||.|:.:|.|:||..|.|:....|...
Human   393 PPVPAVSRCCTQDIVLPDGR-VIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPKNIKERSPL 456

  Fly   508 AFVPFSAGPRSCVGRKYAMLKLKILLSTILRNYRVYSDLTESDFKLQADIILKREEGFRVRLQP 571
            ||:|||||||:|:|:.:||.::|::|...|..:||..|.||.  :.:.:::|:.|.|..:|::|
Human   457 AFIPFSAGPRNCIGQAFAMAEMKVVLGLTLLRFRVLPDHTEP--RRKPELVLRAEGGLWLRVEP 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4g15	NP_572721.1	p450	47..542	CDD:278495	148/504 (29%)
CYP4F3	NP_000887.2	p450	52..515	CDD:365848	156/531 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.820