DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4g15 and Cyp4p3

DIOPT Version :9

Sequence 1:	NP_572721.1	Gene:	Cyp4g15 / 32093	FlyBaseID:	FBgn0030304	Length:	574	Species:	Drosophila melanogaster
Sequence 2:	NP_610473.1	Gene:	Cyp4p3 / 35948	FlyBaseID:	FBgn0033397	Length:	515	Species:	Drosophila melanogaster

Alignment Length:	581	Identity:	158/581 - (27%)
Similarity:	267/581 - (45%)	Gaps:	101/581 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 LVLW-------YIYW--RLSRAH--LYRLAGRL------------PGPRGLPIVGHLFDVIGPAS 66
            |:||       .|.|  ||:|.:  |...|.|:            |..:|..|..:.||:.|.
  Fly     2 LILWLVGAFIVLIQWIYRLNRDYCILGFFAKRIRTKNGQNPESIAPLVKGSTIFANSFDLYGK-- 64

  Fly    67 SVFRTVIRKSAPFEH-------IAKMWIGPKLVVFIY---DPRDVELLLSSHVYIDKASEYKFFK 121
                   ..|..|||       :.|.:....:...||   |....|.:|:....|:|.:.|.|..
  Fly    65 -------DHSGVFEHSRDCAKKLGKSYAEYAMGTAIYNVIDADSAERVLNDPNLINKGTIYDFLH 122

  Fly   122 PWLGDGLLISTGQKWRSHRKLIAPTFHLNVLKSFIELFNENSRNVVRKLRAEDGRTFDCHDYMSE 186
            |:|..|||.|||:||.:.||:::||||.|:|..|.|:|...|...:.:.:..|......::.:..
  Fly   123 PFLRTGLLTSTGKKWHARRKMLSPTFHFNILNQFQEIFITESLKFLEQFKGNDEAIISLNEVIPR 187

  Fly   187 ATVEILLETAMGVSKKTQDKSGFEYAMAVMRMCDILHARHRSIFLRNEFVFTLTRYYKEQGRLLN 251
            .|:..:.||||||......:.|..|.....::.:....|..:..|.::.:|.:.. .|:....|:
  Fly   188 FTLNSICETAMGVKLDEMAEKGDRYRENFRQIEECFIRRMSNPLLWSDTLFKMFA-EKDYASALD 251

  Fly   252 IIHGLTTKVIRSKKAAFEQGTRGSLAQCELKAAALEREREQNGGVDQTPSTAGSDEKDREKDKEK 316
            ::||.::::|..::                               ||.     :||.|...:.:.
  Fly   252 VVHGFSSEIIAKRR-------------------------------DQL-----NDEIDSRGNTQT 280

  Fly   317 ASPVAGLSYGQSAGLKDDLDVEDNDIGEKKRLAFLDLMLESAQNGALITDTEIKEQVDTIMFEGH 381
            |                    ||.....|||.|.||.::.:.::| ||....|.|:|||:||||:
  Fly   281 A--------------------EDELFTSKKRFAMLDTLILAEKDG-LIDHIGICEEVDTLMFEGY 324

  Fly   382 DTTAAGSSFFLSLMGIHQDIQDRVLAELDSIFGDSQRPATFQDTLEMKYLERCLMETLRMYPPVP 446
            |||:.|..|.|..|.::.:.|::...|:.:...|...........::|.||..:.||:|::|.||
  Fly   325 DTTSIGLMFGLMNMSLYPEEQEKCYQEIQANIDDELNILNIGQLNKLKNLEYFIKETMRLFPSVP 389

  Fly   447 LIARELQEDLKLNSGNYVIPRGATVTVATVLLHRNPKVYANPNVFDPDNFLPERQANRHYYAFVP 511
            .:.||...:.:|::| .::|:|:.:.|....:||||:.:.:|..|.|:.||||...|||.||::|
  Fly   390 AMGRETTRETELSNG-LILPKGSQIFVHVFDIHRNPEYWDSPEEFRPERFLPENSQNRHTYAYIP 453

  Fly   512 FSAGPRSCVGRKYAMLKLKILLSTILRNYRVYSDLTESDFKLQADIILKREEGFRVRLQPR 572
            ||||.|:|:|:|:||.::|.|:..:|:.:::..::.......|..:.|:.:....|:|..|
  Fly   454 FSAGQRNCIGQKFAMQEMKTLMVALLKQFQILPEIDPKTIVFQTGLTLRTKNQIHVKLVRR 514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4g15	NP_572721.1	p450	47..542	CDD:278495	142/504 (28%)
Cyp4p3	NP_610473.1	p450	54..505	CDD:278495	142/518 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
	6	6.070