DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4g15 and Cyp4f18

DIOPT Version :9

Sequence 1:	NP_572721.1	Gene:	Cyp4g15 / 32093	FlyBaseID:	FBgn0030304	Length:	574	Species:	Drosophila melanogaster
Sequence 2:	NP_001028858.2	Gene:	Cyp4f18 / 290623	RGDID:	1305261	Length:	524	Species:	Rattus norvegicus

Alignment Length:	581	Identity:	167/581 - (28%)
Similarity:	276/581 - (47%)	Gaps:	92/581 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LGSPSSVFYFLLL---PTLVLWYIYWRLSRAHLY----RLAGRLPGPRGLPIVGHLFDVIGPASS 67
            ||..::..:.|||   .:.:|.||   |.:.:..    |...|.|.|   |....||..:|...|
  Rat    11 LGHTAASPWLLLLLVGASCLLAYI---LPQVYAVFENSRRLRRFPQP---PTRNWLFGHLGLIQS 69

  Fly    68 VFRTVI---RKSAPFEHIAKMWIGP-KLVVFIYDPRDVE--LLLSSHVYIDKASEYKFFKPWLGD 126
            ....::   ..|..|..:...|:|| ..|:.|:.|..::  :|..:.|.......|:|.||||||
  Rat    70 SEEGLLYIQSLSRTFRDVCCWWVGPWHPVIRIFHPAFIKPVILAPASVAPKDRVFYRFLKPWLGD 134

  Fly   127 GLLISTGQKWRSHRKLIAPTFHLNVLKSFIELFNENSRNVV----RKLRAEDGRTFDCHDYMSEA 187
            |||:|||.||..||.::.|.||.|:||.::::||: |.|::    ::|.::.....|..:::|..
  Rat   135 GLLLSTGDKWSRHRHMLTPAFHFNILKPYVKIFND-STNIMHAKWQRLASQGSARLDMFEHISLM 198

  Fly   188 TVEILLETAMGVSKKTQDKSGFEYAMAVMRMCDILHARHRSIFLRNEFVFTLTRYYKEQGRLLNI 252
            |::.|.:.........|:|.. ||..|::.:..::..||:|:.|..:..:.|||......:...:
  Rat   199 TLDSLQKCVFSFDSNCQEKPS-EYITAILELSALVARRHQSLLLYVDLFYHLTRDGMRFRKACRL 262

  Fly   253 IHGLTTKVIRSKKAAFEQGTRGSLAQCELKAAALEREREQNGGVDQTPSTAGSDEKDREKDKEKA 317
            :|..|..|||                        ||.|        |....|.|  |..|.|.||
  Rat   263 VHDFTDAVIR------------------------ERRR--------TLPDQGGD--DALKAKAKA 293

  Fly   318 SPVAGLSYGQSAGLKDDLDVEDNDIGEKKRLAFLD-LMLESAQNGALITDTEIKEQVDTIMFEGH 381
                                        |.|.|:| |:|...::|..::|.:|:.:.||.||.||
  Rat   294 ----------------------------KTLDFIDVLLLSKDEHGEALSDEDIRAEADTFMFGGH 330

  Fly   382 DTTAAGSSFFLSLMGIHQDIQDRVLAELDSIFGDSQ-RPATFQDTLEMKYLERCLMETLRMYPPV 445
            ||||:|.|:.|..:..|.:.|:|...|:..:..|.: ....:.|..::.:|..|:.|:||::||.
  Rat   331 DTTASGLSWILYNLAKHPEYQERCRQEVRELLRDREPEEIEWDDLAQLPFLTMCIKESLRLHPPA 395

  Fly   446 PLIARELQEDLKLNSGNYVIPRGATVTVATVLLHRNPKVYANPNVFDPDNFLPERQANRHYYAFV 510
            ..|:|...:|:.|..|. |||:|....::....|.||.|:.:|.|::|..|..:....|...||:
  Rat   396 TAISRCCTQDIMLPDGR-VIPKGVICRISIFGTHHNPAVWPDPEVYNPFRFDADNGEGRSPLAFI 459

  Fly   511 PFSAGPRSCVGRKYAMLKLKILLSTILRNYRVYSDLTESDFKLQADIILKREEGFRVRLQP 571
            |||||||:|:|:.:||.::|:.|:..|..:||..|  :.:.:.:.::||:.|.|..:|::|
  Rat   460 PFSAGPRNCIGQTFAMSEMKVALALTLLRFRVLPD--DKEPRRKPELILRAEGGLWLRVEP 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4g15	NP_572721.1	p450	47..542	CDD:278495	147/506 (29%)
Cyp4f18	NP_001028858.2	CYP4F	74..515	CDD:410772	147/507 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.820