DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4g15 and Cyp4f5

DIOPT Version :9

Sequence 1:	NP_572721.1	Gene:	Cyp4g15 / 32093	FlyBaseID:	FBgn0030304	Length:	574	Species:	Drosophila melanogaster
Sequence 2:	NP_775147.1	Gene:	Cyp4f5 / 286905	RGDID:	708364	Length:	526	Species:	Rattus norvegicus

Alignment Length:	576	Identity:	160/576 - (27%)
Similarity:	275/576 - (47%)	Gaps:	80/576 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LGSPSSVFYFLLLPTLVLWYIYWRLSRAHLY-----RLAGRLPGPRGLPIVGHLFDVIGPASSVF 69
            |||..:..:.|||.....|.:...|:..:.:     ||......|:....:||| ..|.......
  Rat    11 LGSVVTSTWHLLLLGAASWILARILAWTYSFCENCSRLRCFPQSPKRNWFLGHL-GTIQSNEEGM 74

  Fly    70 RTVIRKSAPFEHIAKMWIGPKL-VVFIYDPRDVELLLSSHVYI-DKASEY-KFFKPWLGDGLLIS 131
            |.|......|..|...|:||.: |:.:.||..|..||.:...: .|.:.: :|.||||||||.:|
  Rat    75 RLVTEMGQTFRDIHLCWLGPVIPVLRLVDPAFVAPLLQAPALVAPKDTTFLRFLKPWLGDGLFLS 139

  Fly   132 TGQKWRSHRKLIAPTFHLNVLKSFIELFNENSRNVV----RKLRAEDGRTFDCHDYMSEATVEIL 192
            :|.||..||:|:.|.||.::||.::::||: |.|::    :.|..|.....:..:.:|..|::.|
  Rat   140 SGDKWSRHRRLLTPAFHFDILKPYVKIFNQ-SVNIMHAKWKHLCLEGSARLEMFENISLMTLDSL 203

  Fly   193 LETAMGVSKKTQDKSGFEYAMAVMRMCDILHARHRSIFLRNEFVFTLTRYYKEQGRLLNIIHGLT 257
            .:...|.....|: |..||..|::.:..::..|.:.:||..:|::..|...:...:..:::|..|
  Rat   204 QKCLFGFDSNCQE-SPSEYISAILELSSLIIKRSQQLFLYLDFLYYRTADGRRFRKACDLVHNFT 267

  Fly   258 TKVIRSKKAAFEQGTRGSLAQCELKAAALEREREQNGGVDQTPSTAGSDEKDREKDKEKASPVAG 322
            ..|||.::...                                |:.|:||....|.|.|:
  Rat   268 DAVIRERRRLL--------------------------------SSQGTDEFLESKTKSKS----- 295

  Fly   323 LSYGQSAGLKDDLDVEDNDIGEKKRLAFLD-LMLESAQNGALITDTEIKEQVDTIMFEGHDTTAA 386
                                   |.|.|:| |:|...::|..::|.:|:.:.||.||.||||||:
  Rat   296 -----------------------KTLDFIDVLLLAKDEHGKELSDEDIRAEADTFMFGGHDTTAS 337

  Fly   387 GSSFFLSLMGIHQDIQDRVLAELDSIFGDSQ-RPATFQDTLEMKYLERCLMETLRMYPPVPLIAR 450
            ..|:.|..:..|.:.|:|...|:..:..|.: ....:.|..::.:|..|:.|:||::||...:.|
  Rat   338 ALSWILYNLARHPEYQERCRQEVWELLRDREPEEIEWDDLAQLPFLTMCIKESLRLHPPAIDLLR 402

  Fly   451 ELQEDLKLNSGNYVIPRGATVTVATVLLHRNPKVYANPNVFDPDNFLPERQANRHYYAFVPFSAG 515
            ...:|:.|..|. |||:|....::...:|.||.|:.:|.||||..|..|.:..|...:|:|||||
  Rat   403 RCTQDIVLPDGR-VIPKGNICVISIFGIHHNPSVWPDPEVFDPFRFDSENRQKRSPLSFIPFSAG 466

  Fly   516 PRSCVGRKYAMLKLKILLSTILRNYRVYSDLTESDFKLQADIILKREEGFRVRLQP 571
            ||:|:|:.:||.::|::::..|..:||..|  :.:.:.:.:|||:.|.|..:|::|
  Rat   467 PRNCIGQTFAMNEMKVVVALTLLRFRVLPD--DKEPRRKPEIILRAEGGLWLRMEP 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4g15	NP_572721.1	p450	47..542	CDD:278495	140/503 (28%)
Cyp4f5	NP_775147.1	p450	52..516	CDD:278495	148/529 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D249473at33208
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.820