DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4g15 and CYP4A22

DIOPT Version :9

Sequence 1:	NP_572721.1	Gene:	Cyp4g15 / 32093	FlyBaseID:	FBgn0030304	Length:	574	Species:	Drosophila melanogaster
Sequence 2:	NP_001010969.2	Gene:	CYP4A22 / 284541	HGNCID:	20575	Length:	519	Species:	Homo sapiens

Alignment Length:	584	Identity:	160/584 - (27%)
Similarity:	268/584 - (45%)	Gaps:	93/584 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEVLKKDAALGSPSSVFY---FLLLPTLVLWYIYWRLSRAHLYRLAGRLPGPRGLPIVGHLFDVI 62
            :.||.....||..|.:..   .|:|..|::......|.|..|.:...:.|.|....:.||:.:.
Human     3 VSVLSPSRRLGGVSGILQVTSLLILLLLLIKAAQLYLHRQWLLKALQQFPCPPSHWLFGHIQEF- 66

  Fly    63 GPASSVFRTVIRKSAPFEHIAKMWI-GPKLVVFIYDPRDVELLL-----SSHVYIDKASEYKFFK 121
             ......:.:..:...|......|| |.|:.|.:|||..::::|     .||      ..|||..
Human    67 -QHDQELQRIQERVKTFPSACPYWIWGGKVRVQLYDPDYMKVILGRSDPKSH------GSYKFLA 124

  Fly   122 PWLGDGLLISTGQKWRSHRKLIAPTFHLNVLKSFIELFNENSRNVVRK---LRAEDGRTFDCHDY 183
            |.:|.|||:..||.|..||:::.|.||.::||.::.|..::.|.::.|   |..:|. ..:...:
Human   125 PRIGYGLLLLNGQTWFQHRRMLTPAFHNDILKPYVGLMADSVRVMLDKWEELLGQDS-PLEVFQH 188

  Fly   184 MSEATVEILLETAMGVSKKTQ-DKSGFEYAMAVMRMCDILHARHRSIFLRNEFVFTLTRYYKEQG 247
            :|..|::.::::|.......| |::...|..|:..:..::....|:.|..|:.:::||...:...
Human   189 VSLMTLDTIMKSAFSHQGSIQVDRNSQSYIQAISDLNSLVFCCMRNAFHENDTIYSLTSAGRWTH 253

  Fly   248 RLLNIIHGLTTKVIRSKKAAFEQGTRGSLAQCELKAAALEREREQNGGVDQTPSTAGSDEKDREK 312
            |...:.|..|.:||:.:||..:                                        :|.
Human   254 RACQLAHQHTDQVIQLRKAQLQ----------------------------------------KEG 278

  Fly   313 DKEKASPVAGLSYGQSAGLKDDLDVEDNDIGEKKRLAFLD-LMLESAQNGALITDTEIKEQVDTI 376
            :.||                         |..|:.|.||| |:|...:||::::|.:::.:|||.
Human   279 ELEK-------------------------IKRKRHLDFLDILLLAKMENGSILSDKDLRAEVDTF 318

  Fly   377 MFEGHDTTAAGSSFFLSLMGIHQDIQDRVLAELDSIFGDSQRPATFQDTLEMKYLERCLMETLRM 441
            |||||||||:|.|:.|..:..|...|:|...|:..:.||. ...|:....:|.|...|:.|.||:
Human   319 MFEGHDTTASGISWILYALATHPKHQERCREEIHGLLGDG-ASITWNHLDQMPYTTMCIKEALRL 382

  Fly   442 YPPVPLIARELQEDLKLNSGNYVIPRGATVTVATVLLHRNPKVYANPNVFDPDNFLPERQANRHY 506
            |||||.|.|||...:....|. .:|:|..|.::...||.||||:.|..||||..|.|  .:.:|.
Human   383 YPPVPGIGRELSTPVTFPDGR-SLPKGIMVLLSIYGLHHNPKVWPNLEVFDPSRFAP--GSAQHS 444

  Fly   507 YAFVPFSAGPRSCVGRKYAMLKLKILLSTILRNYRVYSDLTESDFKLQADIILKREEGFRVRLQ 570
            :||:|||.|.|:|:|:::||.:||:..:..|..:.:..|.|.....: |.::||.:.|..:||:
Human   445 HAFLPFSGGSRNCIGKQFAMNQLKVARALTLLRFELLPDPTRIPIPM-ARLVLKSKNGIHLRLR 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4g15	NP_572721.1	p450	47..542	CDD:278495	141/505 (28%)
CYP4A22	NP_001010969.2	p450	52..505	CDD:278495	147/531 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.810