DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4g15 and Cyp4b1

DIOPT Version :9

Sequence 1:	NP_572721.1	Gene:	Cyp4g15 / 32093	FlyBaseID:	FBgn0030304	Length:	574	Species:	Drosophila melanogaster
Sequence 2:	NP_058695.2	Gene:	Cyp4b1 / 24307	RGDID:	2480	Length:	511	Species:	Rattus norvegicus

Alignment Length:	574	Identity:	172/574 - (29%)
Similarity:	274/574 - (47%)	Gaps:	88/574 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LGSPSSVFYFLLLPTLVLWYIYWRLSRAHLYRLAGRLPGPRGLPIVGHLFDV--IGPASSVFRTV 72
            ||..:||   ::|..:||......|.|..|.|.....|||....:.||..::  :|....    |
  Rat    13 LGLWASV---VILMVIVLKLFSLLLRRQKLARAMDSFPGPPTHWLFGHALEIQKLGSLDK----V 70

  Fly    73 IRKSAPFEHIAKMWIGPKLVVF--IYDPRDVELLLSSHVYIDKASEYKFFKPWLGDGLLISTGQK 135
            :..:..|.|...:|.| :.|.|  ||:| |....:.|......|..|.||..|:|.|||:..|.|
  Rat    71 VSWAQQFPHAHPLWFG-QFVGFLNIYEP-DYAKAVYSRGDPKAADVYDFFLQWIGKGLLVLDGPK 133

  Fly   136 WRSHRKLIAPTFHLNVLKSFIELFNENSRNVVRK--LRAEDGRTFDCHDYMSEATVEILLETAMG 198
            |..||||:.|.||.:|||.::.:|.|::|.::.|  .:|.:.::||....:....::.|::...|
  Rat   134 WFQHRKLLTPGFHYDVLKPYVAIFAESTRMMLDKWEKKASENKSFDIFCDVGHMALDTLMKCTFG 198

  Fly   199 VSKKTQDKSGFEYAMAVMRMCDILHARHRSIFLRNEFVFTLTRYYKEQGRLLNIIHGLTTKVIRS 263
            ............|.:||..:..::..|..|....|:|::.||.:.:...|...|.|..|.:|||.
  Rat   199 KGDSGLGHRDNSYYLAVSDLTLLMQQRIDSFQYHNDFIYWLTPHGRRFLRACKIAHDHTDEVIRQ 263

  Fly   264 KKAAFEQGTRGSLAQCELKAAALEREREQNGGVDQTPSTAGSDEKDREKDKEKASPVAGLSYGQS 328
            :|||.:                                    |||:|:|
  Rat   264 RKAALQ------------------------------------DEKERKK---------------- 276

  Fly   329 AGLKDDLDVEDNDIGEKKRLAFLDLML-ESAQNGALITDTEIKEQVDTIMFEGHDTTAAGSSFFL 392
                         |.:::.|.|||::| ...::|..::|.|::.:|||.||||||||.:|.|:||
  Rat   277 -------------IQQRRHLDFLDILLGVRDESGIKLSDAELRAEVDTFMFEGHDTTTSGISWFL 328

  Fly   393 SLMGIHQDIQDRVLAELDSIFGDSQRPATFQ--DTLEMKYLERCLMETLRMYPPVPLIARELQED 455
            ..|.::.:.|.....|:..|.||..   :||  |..:|.||..|:.|..|:|||||.:.|:|.:.
  Rat   329 YCMALYPEHQQLCREEVRGILGDQD---SFQWDDLAKMTYLTMCMKECFRLYPPVPQVYRQLNKP 390

  Fly   456 LKLNSGNYVIPRGATVTVATVLLHRNPKVYANPNVFDPDNFLPERQANRHYYAFVPFSAGPRSCV 520
            :....|. .:|.|:.:::....||||..|:.:|.||||..|.||..|.||.:||:|||||||:|:
  Rat   391 VTFVDGR-SLPAGSLISLHIYALHRNSTVWPDPEVFDPLRFSPENAAGRHPFAFMPFSAGPRNCI 454

  Fly   521 GRKYAMLKLKILLSTILRNYRVYSDLTESDFKLQADIILKREEGFRVRLQPRTS 574
            |:::||.::|::.:..|..:....|.::...|: ..:||:.:.|..:.|:|..|
  Rat   455 GQQFAMNEMKVVTALCLLRFEFSLDPSKMPIKV-PQLILRSKNGIHLYLKPLAS 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4g15	NP_572721.1	p450	47..542	CDD:278495	153/503 (30%)
Cyp4b1	NP_058695.2	p450	47..500	CDD:278495	158/528 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.820