Protein Alignment Cyp4g15 and CYP26A1

DIOPT Version :10

• Sequence 1: NP_572721.1
• Gene: Cyp4g15 / 32093
• FlyBaseID: FBgn0030304
• Length: 574
• Species: Drosophila melanogaster
• Sequence 2: NP_000774.2
• Gene: CYP26A1 / 1592
• HGNCID: 2603
• Length: 497
• Species: Homo sapiens
• Alignment Length: 576
• Identity: 119/576 - (20%)
• Similarity: 206/576 - (35%)
• Gaps: 162/576 - (28%)

  Fly     8 AALGSPSSVF---YFLLLPTLVLWYIYWRLSRAHLYRLAGR--------LPGPRGLPIVG----- 56
            |.|.|....|   ..|.|..:.||         .||.::||        .||..|.|..|
Human     5 ALLASALCTFVLPLLLFLAAIKLW---------DLYCVSGRDRSCALPLPPGTMGFPFFGETLQM 60

  Fly    57 ---------------------HLFDVIGPASSVFRTVIRKSAPFEHIAKMWIGPKLVVFIYDPRD 100
                                 |||.         |..:|.... :::.::.:|...:|.::.|..
Human    61 VLQRRKFLQMKRRKYGFIYKTHLFG---------RPTVRVMGA-DNVRRILLGEHRLVSVHWPAS 115

  Fly   101 VELLLSSHVYIDKASEYKFFKPWLGDGLLIST-GQKWRSHRKLIAPTFHLNVLKSFIELFNENSR 164
            |..:                   ||.|.|.:. ....:..:|:|...|....|:.::.:..|...
Human   116 VRTI-------------------LGSGCLSNLHDSSHKQRKKVIMRAFSREALECYVPVITEEVG 161

  Fly   165 NVVRKLRAEDGRTFDCHDYMSEATVEILLETAMGVSKKTQDKSGFEYAMAVMRMCDILHARHRSI 229
            :.:.:..:...|....:..:......|.:...:|...:.......|     .::.:......|::
Human   162 SSLEQWLSCGERGLLVYPEVKRLMFRIAMRILLGCEPQLAGDGDSE-----QQLVEAFEEMTRNL 221

  Fly   230 F-LRNEFVFT-LTRYYKEQGRLLNIIHGLTTKVIRSKKAAFEQGTRGSLAQCELKAAALEREREQ 292
            | |..:..|: |.|..|.:    |:||           |..||..|..:  |.|:|
Human   222 FSLPIDVPFSGLYRGMKAR----NLIH-----------ARIEQNIRAKI--CGLRA--------- 260

  Fly   293 NGGVDQTPSTAGSDEKDREKDKEKASPVAGLSYGQSAGLKDDLDVEDNDIGEKKRLAFLDLMLES 357
                    |.||.                        |.||.|.:               |:..|
Human   261 --------SEAGQ------------------------GCKDALQL---------------LIEHS 278

  Fly   358 AQNGALITDTEIKEQVDTIMFEGHDTTAAGSSFFLSLMGIHQDIQDRVLAELDS---IFGDSQRP 419
            .:.|..:....:|:....::|.||:|||:.::..::.:|::..:..:|..||.|   :...:|..
Human   279 WERGERLDMQALKQSSTELLFGGHETTASAATSLITYLGLYPHVLQKVREELKSKGLLCKSNQDN 343

  Fly   420 ATFQDTLE-MKYLERCLMETLRMYPPVPLIARELQEDLKLNSGNYVIPRGATVTVATVLLHRNPK 483
            ....:.|| :||:...:.||||:.||||...|...:..:||  .|.||:|..|..:....|...:
Human   344 KLDMEILEQLKYIGCVIKETLRLNPPVPGGFRVALKTFELN--GYQIPKGWNVIYSICDTHDVAE 406

  Fly   484 VYANPNVFDPDNFLPERQANRHYYAFVPFSAGPRSCVGRKYAMLKLKILLSTILRN 539
            ::.|...|:||.|:.....:...::|:||..|.|||||:::|.:.|||....:.|:
Human   407 IFTNKEEFNPDRFMLPHPEDASRFSFIPFGGGLRSCVGKEFAKILLKIFTVELARH 462

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4g15	NP_572721.1	CYP4	80..567	CDD:410721	97/467 (21%)
CYP26A1	NP_000774.2	CYP26A1	55..490	CDD:410731	103/517 (20%)