Protein Alignment Cyp4g15 and CYP19A1

DIOPT Version :10

• Sequence 1: NP_572721.1
• Gene: Cyp4g15 / 32093
• FlyBaseID: FBgn0030304
• Length: 574
• Species: Drosophila melanogaster
• Sequence 2: NP_000094.2
• Gene: CYP19A1 / 1588
• HGNCID: 2594
• Length: 503
• Species: Homo sapiens
• Alignment Length: 589
• Identity: 126/589 - (21%)
• Similarity: 223/589 - (37%)
• Gaps: 165/589 - (28%)

  Fly    13 PSSVFYFLLLPTLVLWYIYWRLSRAHLYRLAGRLPGP---RGL-PIVGH---LFDVIGPASSVFR 70
            |::....|||..|.|  :.|.      |.....:|||   .|: |::.|   |:..||.|.:.:.
Human    22 PAATMPVLLLTGLFL--LVWN------YEGTSSIPGPGYCMGIGPLISHGRFLWMGIGSACNYYN 78

  Fly    71 TVIRKSAPFEHIAKMWIGPKLVVFIYDPRDVELLLSSHVYIDKASEYKF-FKPWLG--------D 126
            .|      :....::||..:..:.|...       ||..:|.|.:.|.. |...||        .
Human    79 RV------YGEFMRVWISGEETLIISKS-------SSMFHIMKHNHYSSRFGSKLGLQCIGMHEK 130

  Fly   127 GLLISTG-QKWRSHRKLIAPTFHLNVLKSFIELFNENSRNVVRKLR--AEDGRTFDCH-DYMSEA 187
            |::.:.. :.|::.|     .|.:..|         :...:||.:.  ||..:|   | |.:.|.
Human   131 GIIFNNNPELWKTTR-----PFFMKAL---------SGPGLVRMVTVCAESLKT---HLDRLEEV 178

  Fly   188 TVEILLETAMGVSKKTQDKSGFEYAMAVMRMCDILHARHRSIFLR-----NEFVFTLTRYYKEQG 247
            |                ::||:...:.::|.  ::.....::|||     :..|..:..|:....
Human   179 T----------------NESGYVDVLTLLRR--VMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQ 225

  Fly   248 RLLNIIHGLTTKVIRSKKAAFEQGTRGSLAQCELKAAALEREREQNGGVDQTPSTAGSDEKDREK 312
            .||            .|...|            .|.:.|.::.|::                 .|
Human   226 ALL------------IKPDIF------------FKISWLYKKYEKS-----------------VK 249

  Fly   313 DKEKASPVAGLSYGQSAGLKDDLDVEDNDIGEKKRLAFLDLMLESAQNGAL----------ITDT 367
            |                 |||.::|.   |.||:|....:..||...:.|.          :|..
Human   250 D-----------------LKDAIEVL---IAEKRRRISTEEKLEECMDFATELILAEKRGDLTRE 294

  Fly   368 EIKEQVDTIMFEGHDTTAAGSSFFLSLMGIHQDIQDRVLAELDSIFGDSQRPATFQDTLEMKYLE 432
            .:.:.:..::....||.:....|.|.|:..|.::::.::.|:.::.|  :|.....|..::|.:|
Human   295 NVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIG--ERDIKIDDIQKLKVME 357

  Fly   433 RCLMETLRMYPPVPLIARELQEDLKLNSGNYVIPRGATVTVATVLLHRNPKVYANPNVFDPDNFL 497
            ..:.|::|..|.|.|:.|:..||..::  .|.:.:|..:.:....:|| .:.:..||.|..:||
Human   358 NFIYESMRYQPVVDLVMRKALEDDVID--GYPVKKGTNIILNIGRMHR-LEFFPKPNEFTLENF- 418

  Fly   498 PERQANRHYYAFVPFSAGPRSCVGRKYAMLKLKILLSTILRNYRV---YSDLTESDFKLQADIIL 559
               ..|..|..|.||..|||.|.|:..||:.:|.:|.|:||.:.|   .....||..|:. |:.|
Human   419 ---AKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIH-DLSL 479

  Fly   560 KREE 563
            ..:|
Human   480 HPDE 483

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4g15	NP_572721.1	CYP4	80..567	CDD:410721	107/515 (21%)
CYP19A1	NP_000094.2	CYP19A1	72..485	CDD:410709	109/531 (21%)