DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4g15 and Cyp46a1

DIOPT Version :9

Sequence 1:	NP_572721.1	Gene:	Cyp4g15 / 32093	FlyBaseID:	FBgn0030304	Length:	574	Species:	Drosophila melanogaster
Sequence 2:	NP_034140.1	Gene:	Cyp46a1 / 13116	MGIID:	1341877	Length:	500	Species:	Mus musculus

Alignment Length:	581	Identity:	137/581 - (23%)
Similarity:	234/581 - (40%)	Gaps:	125/581 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 LLLPTLVLWYIYWRLSRAHLYRLAGR---LPG-PRGLPIVGHL-------FDVIGPASSVFRTVI 73
            |||.:.||  :.:.|....::|...|   :|| ||...::|||       .|.......||....
Mouse     6 LLLGSAVL--LAFGLCCTFVHRARSRYEHIPGPPRPSFLLGHLPYFWKKDEDCGRVLQDVFLDWA 68

  Fly    74 RKSAPFEHIAKMWIGPKLVVFIYDPRDVELLLSSHVYIDKASEYKFFKPWLGDGLLISTGQ---- 134
            :|..|   :.::.:..|..|.:..|..|:..|.|..|...:..|:..:...|:.|.   ||
Mouse    69 KKYGP---VVRVNVFYKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLF---GQGLVS 127

  Fly   135 -----KWRSHRKLIAPTFHLNVLKSFIELFNENSRNVVRKLRAE-DGRT-FDCHDYMSEATVEIL 192
                 :|...||::...|..:.|.|.:|.|||.:..:|..|.|: ||:| ....|.::.||::||
Mouse   128 ECDYGRWYKQRKVMDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTCATIDIL 192

  Fly   193 LETAMGV--SKKTQDKSGFEYAMAVMRMCDILHARHRSIFLRNEFVFTLTRYYKEQGRLLNIIHG 255
            .:.|.|:  |.....:.....|:.||                                    :.|
Mouse   193 AKAAFGMETSMLLGAQKPLSQAVKVM------------------------------------LEG 221

  Fly   256 LTTKVIRSKKAAFEQGTRGSLAQCELKAAALEREREQNGGVDQTPSTAGSDEKDREKDKEKASPV 320
            ::..  |:..|.|..|.|..|.:.......|.:              .|.|...|.::..|.
Mouse   222 ISAS--RNTLAKFMPGKRKQLREIRESIRLLRQ--------------VGKDWVQRRREALKR--- 267

  Fly   321 AGLSYGQSAGLKDDLDVEDNDIGEKKRLAFLDLML---ESAQNGALITDTEIKEQVDTIMFEGHD 382
                                  ||......|..:|   |.||:..::.|..:     |....||:
Mouse   268 ----------------------GEDMPADILTQILKAEEGAQDDEVLLDNFV-----TFFIAGHE 305

  Fly   383 TTAAGSSFFLSLMGIHQDIQDRVLAELDSIFGDSQRPATFQDTLEMKYLERCLMETLRMYPPVPL 447
            |:|...:|.:..:....:|..|:.||:|.:.| |:|...::|...::||.:.|.|:||:|||...
Mouse   306 TSANHLAFTVMELSRQPEIVARLQAEVDEVVG-SKRHLDYEDLGRLQYLSQVLKESLRLYPPAWG 369

  Fly   448 IARELQEDLKLNSGNYVIPRGATVTVATVLLHRNPKVYANPNVFDPDNFLPERQANRHYYAFVPF 512
            ..|.|:|:..::...  :|....:..:|.::.|....:.:|..|:||.|.|  .|.:..:.:.||
Mouse   370 TFRLLEEETLIDGVR--VPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGP--GAPKPRFTYFPF 430

  Fly   513 SAGPRSCVGRKYAMLKLKILLSTILRNYRVYSDLTESD-FKLQADIILKREEGFRVRLQPR 572
            |.|.|||:|:::|.:::|::::.:|:  |:...|.... |.||....||..:.....|:||
Mouse   431 SLGHRSCIGQQFAQMEVKVVMAKLLQ--RIEFRLVPGQRFGLQEQATLKPLDPVLCTLRPR 489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4g15	NP_572721.1	p450	47..542	CDD:278495	119/518 (23%)
Cyp46a1	NP_034140.1	p450	34..466	CDD:278495	121/526 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000