DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4g15 and Cyp19a1

DIOPT Version :9

Sequence 1:	NP_572721.1	Gene:	Cyp4g15 / 32093	FlyBaseID:	FBgn0030304	Length:	574	Species:	Drosophila melanogaster
Sequence 2:	NP_001335100.1	Gene:	Cyp19a1 / 13075	MGIID:	88587	Length:	503	Species:	Mus musculus

Alignment Length:	562	Identity:	127/562 - (22%)
Similarity:	219/562 - (38%)	Gaps:	159/562 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 SVFYFLLLPTLVLWYIYWRLSRAHLYRLAGRLPGP---RGL-PIVGH---LFDVIGPASSVFRTV 72
            |....||:..|:|  :.|....      :..:|||   .|: |::.|   |:..||.|.:.:..:
Mouse    24 SAMPLLLIMGLLL--LIWNCES------SSSIPGPGYCLGIGPLISHGRFLWMGIGSACNYYNKM 80

  Fly    73 IRKSAPFEHIAKMWIGPKLVVFIYDPRDVELLLSSHVYIDKASEYKFFKPWLGDGLLISTGQKWR 137
                  :....::||..:..:.|...       ||..::.|.|.|            ||   ::.
Mouse    81 ------YGEFMRVWISGEETLIISKS-------SSMFHVMKHSHY------------IS---RFG 117

  Fly   138 SHRKLIAPTFHLNVLKSFIELFNENSRNVVRKLRAEDGRTFDCHDYMSEAT-------VEILLET 195
            |.|.|.....|.|.:     :|| |:.::.|.:|.         .:|...|       ||:.:|:
Mouse   118 SKRGLQCIGMHENGI-----IFN-NNPSLWRTIRP---------FFMKALTGPGLVRMVEVCVES 167

  Fly   196 ------AMGVSKKTQDKSGFEYAMAVMRMCDILHARHRSIFL-----RNEFVFTLTRYYKEQGRL 249
                  .:|   :..|.||:...:.:||  .|:......:||     .:..|..:..|:.....|
Mouse   168 IKQHLDRLG---EVTDTSGYVDVLTLMR--HIMLDTSNMLFLGIPLDESAIVKKIQGYFNAWQAL 227

  Fly   250 L---NI---IHGLTTKVIRSKKAAFEQGTRGSLAQCELK---AAALEREREQNGGVDQTPSTAGS 305
            |   ||   |..|..|..||.|              :||   |..:|::|.:       .|||
Mouse   228 LIKPNIFFKISWLYRKYERSVK--------------DLKDEIAVLVEKKRHK-------VSTA-- 269

  Fly   306 DEKDREKDKEKASPVAGLSYGQSAGLKDDLDVEDNDIGEKKRLAFLDLMLESAQNGALITDTEIK 370
                     ||              |:|.:|..            .||:.  |:....:|...:.
Mouse   270 ---------EK--------------LEDCMDFA------------TDLIF--AERRGDLTKENVN 297

  Fly   371 EQVDTIMFEGHDTTAAGSSFFLSLMGIHQDIQDRVLAELDSIFGDSQRPATFQDTLEMKYLERCL 435
            :.:..::....||.:....|.|.|:..:.:::..:|.|:.::.||  |....:|...:|.:|..:
Mouse   298 QCILEMLIAAPDTMSVTLYFMLLLVAEYPEVEAAILKEIHTVVGD--RDIKIEDIQNLKVVENFI 360

  Fly   436 METLRMYPPVPLIARELQEDLKLNSGNYVIPRGATVTVATVLLHRNPKVYANPNVFDPDNFLPER 500
            .|::|..|.|.|:.|...||..::  .|.:.:|..:.:....:|| .:.:..||.|..:||
Mouse   361 NESMRYQPVVDLVMRRALEDDVID--GYPVKKGTNIILNIGRMHR-LEYFPKPNEFTLENF---- 418

  Fly   501 QANRHYYAFVPFSAGPRSCVGRKYAMLKLKILLSTILRNYRV 542
            :.|..|..|.||..|||.|.|:..||:.:|::|.|:||.::|
Mouse   419 EKNVPYRYFQPFGFGPRGCAGKYIAMVMMKVVLVTLLRRFQV 460

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4g15	NP_572721.1	p450	47..542	CDD:278495	120/528 (23%)
Cyp19a1	NP_001335100.1	p450	48..488	CDD:306555	121/530 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24291
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.110