DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG43155 and KCNK5

DIOPT Version :10

Sequence 1:NP_572720.2 Gene:CG43155 / 32092 FlyBaseID:FBgn0262685 Length:411 Species:Drosophila melanogaster
Sequence 2:NP_003731.1 Gene:KCNK5 / 8645 HGNCID:6280 Length:499 Species:Homo sapiens


Alignment Length:393 Identity:103/393 - (26%)
Similarity:158/393 - (40%) Gaps:99/393 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    68 LLVSLSI-YCGVGGLIFRHLERPAEVERLSHLKDIVKTHRERFLHTI-----LNNTEVHNLDELL 126
            ||.|..| |..:|..||..||.|       |.|:..|.:..:.||.:     |..   ..||::|
Human     7 LLTSAIIFYLAIGAAIFEVLEEP-------HWKEAKKNYYTQKLHLLKEFPCLGQ---EGLDKIL 61

  Fly   127 SFELAKYEAAVQQAAEGGLLIVADKDFPEPYERWSILQAVFFSSTVLTTIGYGNIVPVTTGGRVF 191
            .        .|..||..|:.|..::.|    ..|:...|:.|::||:|||||||:.|.|..||:|
Human    62 E--------VVSDAAGQGVAITGNQTF----NNWNWPNAMIFAATVITTIGYGNVAPKTPAGRLF 114

  Fly   192 CICFALIGIPFTLTVIADWGRLFATAVSVFGKHMPTKPKFTNFIGKTWFYAILAVGFLGVYLAAG 256
            |:.:.|.|:|..||.|:..|:.|.......|:.:..:.........|.....:..|.| |:|...
Human   115 CVFYGLFGVPLCLTWISALGKFFGGRAKRLGQFLTKRGVSLRKAQITCTVIFIVWGVL-VHLVIP 178

  Fly   257 AGLLLLWEDDWTFFDGFYFCFITMTTIGFGDLVP---KKPNYMLL----CTLYILIGLALTSTI- 313
            ..:.::.| .|.:.:|.|:.|||::||||||.|.   ...||..|    ..|:|.:|||..|.. 
Human   179 PFVFMVTE-GWNYIEGLYYSFITISTIGFGDFVAGVNPSANYHALYRYFVELWIYLGLAWLSLFV 242

  Fly   314 -------------IELVRRQYATSWAKLQELSGPMAETLRRLGETAGTGLDYTALQKVLTVSMPK 365
                         |:..||:...|:    |.|....:.|:..|.||..           .|::..
Human   243 NWKVSMFVEVHKAIKKRRRRRKESF----ESSPHSRKALQVKGSTASK-----------DVNIFS 292

  Fly   366 WNSKKNEHSPDIAALEAITNAILKEV-KEAQNNK----------------------PKVLQIVIY 407
            :.|||.|          ..|.::|:: |:|....                      |.::.:|:|
Human   293 FLSKKEE----------TYNDLIKQIGKKAMKTSGGGETGPGPGLGPQGGGLPALPPSLVPLVVY 347

  Fly   408 ESS 410
            ..:
Human   348 SKN 350

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG43155NP_572720.2 Ion_trans_2 143..214 CDD:462301 28/70 (40%)
Ion_trans_2 <267..319 CDD:462301 23/72 (32%)
KCNK5NP_003731.1 Ion_trans_2 <83..137 CDD:462301 25/53 (47%)
Selectivity filter 1. /evidence=ECO:0000250|UniProtKB:P57789 98..103 4/4 (100%)
Ion_trans_2 171..243 CDD:462301 26/73 (36%)
Selectivity filter 2. /evidence=ECO:0000250|UniProtKB:P57789 203..208 4/4 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 312..335 1/22 (5%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 360..388
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 428..499
Blue background indicates that the domain is not in the aligned region.

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