DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG43155 and Kcnk10

DIOPT Version :9

Sequence 1:	NP_572720.2	Gene:	CG43155 / 32092	FlyBaseID:	FBgn0262685	Length:	411	Species:	Drosophila melanogaster
Sequence 2:	NP_075584.1	Gene:	Kcnk10 / 65272	RGDID:	619732	Length:	538	Species:	Rattus norvegicus

Alignment Length:	420	Identity:	116/420 - (27%)
Similarity:	177/420 - (42%)	Gaps:	94/420 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 RVDAAEGGGLAKGTAGGRRSTACWQSMKWKSALNHIGLLVSLSIYCGVGGLIFRHLERPAEVERL 95
            |::.|..|||.             ..||||:.   :.:.|.:.:|...|||:||.||:|.|
  Rat    54 RMEGASQGGLQ-------------TVMKWKTV---VAIFVVVVVYLVTGGLVFRALEQPFE---- 98

  Fly    96 SHLKDIVKTHRERFL--HTILNNTEVHNLDELLSFELAKYEAAVQQAAEGGLLIVADKDFPEPYE 158
            |..|:.:...:..||  |..::..|   |:.|:...|....|.|.......          ....
  Rat    99 SSQKNTIALEKAEFLRDHICVSPQE---LETLIQHALDADNAGVSPVGNSS----------NSSS 150

  Fly   159 RWSILQAVFFSSTVLTTIGYGNIVPVTTGGRVFCICFALIGIP---FTLTVIAD-----WGRLFA 215
            .|.:..|.||:.||:||||||||.|.|.||::|||.:|:.|||   |.|..|.|     :|:..|
  Rat   151 HWDLGSAFFFAGTVITTIGYGNIAPSTEGGKIFCILYAIFGIPLFGFLLAGIGDQLGTIFGKSIA 215

  Fly   216 TAVSVFGKHMPTKPKFTNFIGKTWFYAILAVGFLGVYLAAGAGLLLLWEDDWTFFDGFYFCFITM 280
            ....||.|...::.|. ..|....|  |||...:.|.:.|   ::..:.:.||..:..||..:|:
  Rat   216 RVEKVFRKKQVSQTKI-RVISTILF--ILAGCIVFVTIPA---VIFKYIEGWTALESIYFVVVTL 274

  Fly   281 TTIGFGDLVP-------KKPNYMLLCTLYILIGLALTSTIIELVR-----------------RQY 321
            ||:||||.|.       .:..|..|...:||:|||..:.::.::.                 :.:
  Rat   275 TTVGFGDFVAGGNAGINYREWYKPLVWFWILVGLAYFAAVLSMIGDWLRVLSKKTKEEVGEIKAH 339

  Fly   322 ATSWAKLQELSGPMAETLRRLGETAGTGLDYTALQKVLTV-SMP--KWNSKKNEHSPDI------ 377
            |..|.  ..::....||.|||....     :..||:..|: ||.  :....:..||.|:
  Rat   340 AAEWK--ANVTAEFRETRRRLSVEI-----HDKLQRAATIRSMERRRLGLDQRAHSLDMLSPEKR 397

  Fly   378 ---AALEAITNAILKEVKEAQNNKPKVLQI 404
               |||:  |.......:|:.||:|..|::
  Rat   398 SVFAALD--TGRFKASSQESINNRPNNLRL 425

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43155	NP_572720.2	Ion_trans_2	<157..214	CDD:285168	30/64 (47%)
		Ion_trans	<240..314	CDD:278921	25/80 (31%)
		Ion_trans_2	<266..319	CDD:285168	19/76 (25%)
Kcnk10	NP_075584.1	Ion_trans_2	148..206	CDD:400301	29/57 (51%)
		Ion_trans_2	244..323	CDD:400301	21/81 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	412..444		5/14 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1418
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000030
OrthoInspector	1	1.000	-	-		otm44944
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11003
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.910