Protein Alignment CG43155 and Kcnk10

DIOPT Version :10

• Sequence 1: NP_572720.2
• Gene: CG43155 / 32092
• FlyBaseID: FBgn0262685
• Length: 411
• Species: Drosophila melanogaster
• Sequence 2: NP_075584.1
• Gene: Kcnk10 / 65272
• RGDID: 619732
• Length: 538
• Species: Rattus norvegicus
• Alignment Length: 420
• Identity: 116/420 - (27%)
• Similarity: 177/420 - (42%)
• Gaps: 94/420 - (22%)

  Fly    31 RVDAAEGGGLAKGTAGGRRSTACWQSMKWKSALNHIGLLVSLSIYCGVGGLIFRHLERPAEVERL 95
            |::.|..|||.             ..||||:.   :.:.|.:.:|...|||:||.||:|.|
  Rat    54 RMEGASQGGLQ-------------TVMKWKTV---VAIFVVVVVYLVTGGLVFRALEQPFE---- 98

  Fly    96 SHLKDIVKTHRERFL--HTILNNTEVHNLDELLSFELAKYEAAVQQAAEGGLLIVADKDFPEPYE 158
            |..|:.:...:..||  |..::..|   |:.|:...|....|.|.......          ....
  Rat    99 SSQKNTIALEKAEFLRDHICVSPQE---LETLIQHALDADNAGVSPVGNSS----------NSSS 150

  Fly   159 RWSILQAVFFSSTVLTTIGYGNIVPVTTGGRVFCICFALIGIP---FTLTVIAD-----WGRLFA 215
            .|.:..|.||:.||:||||||||.|.|.||::|||.:|:.|||   |.|..|.|     :|:..|
  Rat   151 HWDLGSAFFFAGTVITTIGYGNIAPSTEGGKIFCILYAIFGIPLFGFLLAGIGDQLGTIFGKSIA 215

  Fly   216 TAVSVFGKHMPTKPKFTNFIGKTWFYAILAVGFLGVYLAAGAGLLLLWEDDWTFFDGFYFCFITM 280
            ....||.|...::.|. ..|....|  |||...:.|.:.|   ::..:.:.||..:..||..:|:
  Rat   216 RVEKVFRKKQVSQTKI-RVISTILF--ILAGCIVFVTIPA---VIFKYIEGWTALESIYFVVVTL 274

  Fly   281 TTIGFGDLVP-------KKPNYMLLCTLYILIGLALTSTIIELVR-----------------RQY 321
            ||:||||.|.       .:..|..|...:||:|||..:.::.::.                 :.:
  Rat   275 TTVGFGDFVAGGNAGINYREWYKPLVWFWILVGLAYFAAVLSMIGDWLRVLSKKTKEEVGEIKAH 339

  Fly   322 ATSWAKLQELSGPMAETLRRLGETAGTGLDYTALQKVLTV-SMP--KWNSKKNEHSPDI------ 377
            |..|.  ..::....||.|||....     :..||:..|: ||.  :....:..||.|:
  Rat   340 AAEWK--ANVTAEFRETRRRLSVEI-----HDKLQRAATIRSMERRRLGLDQRAHSLDMLSPEKR 397

  Fly   378 ---AALEAITNAILKEVKEAQNNKPKVLQI 404
               |||:  |.......:|:.||:|..|::
  Rat   398 SVFAALD--TGRFKASSQESINNRPNNLRL 425

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43155	NP_572720.2	Ion_trans_2	143..214	CDD:462301	30/78 (38%)
		Ion_trans_2	<267..319	CDD:462301	19/75 (25%)
Kcnk10	NP_075584.1	Ion_trans_2	<150..206	CDD:462301	29/55 (53%)
		Selectivity filter 1. /evidence=ECO:0000250|UniProtKB:P57789	167..172		4/4 (100%)
		Ion_trans_2	244..323	CDD:462301	21/81 (26%)
		Selectivity filter 2. /evidence=ECO:0000250|UniProtKB:P57789	276..281		3/4 (75%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	412..444		5/14 (36%)