Protein Alignment CG43155 and Kcnd3

DIOPT Version :10

• Sequence 1: NP_572720.2
• Gene: CG43155 / 32092
• FlyBaseID: FBgn0262685
• Length: 411
• Species: Drosophila melanogaster
• Sequence 2: NP_001257891.1
• Gene: Kcnd3 / 65195
• RGDID: 68394
• Length: 655
• Species: Rattus norvegicus
• Alignment Length: 369
• Identity: 68/369 - (18%)
• Similarity: 120/369 - (32%)
• Gaps: 135/369 - (36%)

  Fly    99 KDIVKTHRERFLHTILNNTEVHNLDE---LLSFELAKYEAAVQQAAEGGLLIVADKDFPEPYERW 160
            ||..:.:.||    ::::.|..|..|   .|||....:.|                 |..|:.
  Rat   137 KDRKRENAER----LMDDNESENNQESMPSLSFRQTMWRA-----------------FENPHT-- 178

  Fly   161 SILQAVFFSST-------VLTTIGYGNIVPVTTGGRV----------------FCICFALIGIPF 202
            |.|..||:..|       |:|     |:|.....|.|                ||:..|.:.| |
  Rat   179 STLALVFYYVTGFFIAVSVIT-----NVVETVPCGTVPGSKELPCGERYSVAFFCLDTACVMI-F 237

  Fly   203 TLTVIADWGRLFATAVSVFGKHMPTKPKFTNFIGKTWFYAILAVGFLGVYL-----AAGA----- 257
            |:..:.   ||||.         |::.:|...:........:...::|:.:     .:||
  Rat   238 TVEYLL---RLFAA---------PSRYRFIRSVMSIIDVVAIMPYYIGLVMTNNEDVSGAFVTLR 290

  Fly   258 ---------------GLLLLW--------EDDWTFFD---------------------------- 271
                           ||.:|.        |..:..|.
  Rat   291 VFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKGSSASKFTSIP 355

  Fly   272 -GFYFCFITMTTIGFGDLVPKKPNYMLLCTLYILIGLALTSTIIELVRRQYATSWAKLQELSGPM 335
             .|::..:||||:|:||:|||.....:..::..|.|:.:.:..:.::...::..:.:.|......
  Rat   356 ASFWYTIVTMTTLGYGDMVPKTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRR 420

  Fly   336 AETLRRLG--ETAGTGLDYTALQK----VLTVSMPKWNSKKNEH 373
            |:...||.  ..|.||.....|..    :|..::....:.:.||
  Rat   421 AQKKARLARIRVAKTGSSNAYLHSKRNGLLNEALELTGTPEEEH 464

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43155	NP_572720.2	Ion_trans_2	143..214	CDD:462301	20/93 (22%)
		Ion_trans_2	<267..319	CDD:462301	14/80 (18%)
Kcnd3	NP_001257891.1	BTB_POZ_KCND3	6..143	CDD:349726	2/5 (40%)
		Interaction with KCNIP1. /evidence=ECO:0000250|UniProtKB:Q9UK17	6..21
		Interaction with KCNIP1. /evidence=ECO:0000250|UniProtKB:Q9UK17	70..78
		Ion_trans	186..412	CDD:459842	40/243 (16%)
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142	367..372		2/4 (50%)
		DUF3399	468..563	CDD:463381
		Interaction with KCNIP1 and KCNIP2. /evidence=ECO:0000250|UniProtKB:Q9UK17	470..487
		Mediates dendritic targeting. /evidence=ECO:0000250|UniProtKB:Q63881	474..489
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	523..565
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	616..647