Protein Alignment CG43155 and Kcnd2

DIOPT Version :10

• Sequence 1: NP_572720.2
• Gene: CG43155 / 32092
• FlyBaseID: FBgn0262685
• Length: 411
• Species: Drosophila melanogaster
• Sequence 2: NP_113918.2
• Gene: Kcnd2 / 65180
• RGDID: 68393
• Length: 630
• Species: Rattus norvegicus
• Alignment Length: 132
• Identity: 31/132 - (23%)
• Similarity: 58/132 - (43%)
• Gaps: 21/132 - (15%)

  Fly   273 FYFCFITMTTIGFGDLVPKK---PNYMLLCTLYILIGLALTSTII-----------ELVRRQYAT 323
            |::..:||||:|:||:|||.   ..:..:|:|..::.:||...:|           :...::.|.
  Rat   361 FWYTIVTMTTLGYGDMVPKTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRRAQ 425

  Fly   324 SWAKLQELSGPMAETLRRLGETAGTGLDYTALQKVLTVSMPKWNSK-----KNEHSPDIAALEAI 383
            ..|:|..:....:.:.....::...||....||.  :...|.:.||     :.:|...:..||..
  Rat   426 KKARLARIRAAKSGSANAYMQSKRNGLLSNQLQS--SEDEPAFVSKSGSSFETQHHHLLHCLEKT 488

  Fly   384 TN 385
            ||
  Rat   489 TN 490

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43155	NP_572720.2	Ion_trans_2	143..214	CDD:462301
		Ion_trans_2	<267..319	CDD:462301	16/59 (27%)
Kcnd2	NP_113918.2	Interaction with KCNIP1, KCNIP2, and other family members. /evidence=ECO:0000305|PubMed:14980206, ECO:0000305|PubMed:14980207	2..20
		BTB_POZ	6..144	CDD:453885
		Interaction with KCNIP1. /evidence=ECO:0000305|PubMed:14980207	71..90
		Ion_trans	184..415	CDD:459842	16/53 (30%)
		S4-S5 linker. /evidence=ECO:0000250|UniProtKB:P63142	308..321
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142	370..375		2/4 (50%)
		DUF3399	470..546	CDD:463381	5/21 (24%)
		Important for normal channel activation and inactivation, for interaction with KCNIP2, and probably other family members as well. /evidence=ECO:0000305|PubMed:16820361	474..630		5/17 (29%)
		Required for dendritic targeting. /evidence=ECO:0000269|PubMed:12592409	474..489		3/14 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	600..623
		PDZ-binding. /evidence=ECO:0000269|PubMed:11923279, ECO:0000269|PubMed:14559911	627..630