DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG43155 and KCNK12

DIOPT Version :10

Sequence 1:NP_572720.2 Gene:CG43155 / 32092 FlyBaseID:FBgn0262685 Length:411 Species:Drosophila melanogaster
Sequence 2:NP_071338.1 Gene:KCNK12 / 56660 HGNCID:6274 Length:430 Species:Homo sapiens


Alignment Length:414 Identity:110/414 - (26%)
Similarity:164/414 - (39%) Gaps:117/414 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    60 KSALNH-----IGLLVSLSIYCGVGGLIFRHLERPAEVERLSHLKDIVKTHRERFLHTILNNTEV 119
            :|.||.     :.|...:.:|...|..:|..||.|.|.|.           |.|:..|:.|.:..
Human    29 RSHLNEDTGRFVLLAALIGLYLVAGATVFSALESPGEAEA-----------RARWGATLRNFSAA 82

  Fly   120 HNL--DELLSFELAKYEAAVQQAAEGGLLIVADKDFPEPYERWSILQAVFFSSTVLTTIGYGNIV 182
            |.:  .||.:| |..||||:   |.|   :.||...|    ||....|.:|..||::|||:|...
Human    83 HGVAEPELRAF-LRHYEAAL---AAG---VRADALRP----RWDFPGAFYFVGTVVSTIGFGMTT 136

  Fly   183 PVTTGGRVFCICFALIGIPFTLTV-----------------------IADWGRLFAT-----AVS 219
            |.|.||:.|.|.:.|.|...|:..                       :...|.|.||     |:|
Human   137 PATVGGKAFLIAYGLFGCAGTILFFNLFLERIISLLAFIMRACRERQLRRSGLLPATFRRGSALS 201

  Fly   220 VFGKHMPTKPKFTNFIGKTWFYAILAVGFLGVYLAAGAGLLLLWEDDWTFFDGFYFCFITMTTIG 284
            ........||..        ::.:|.:|...|.|:..|..:....:.|.:.|..||||:|.:|||
Human   202 EADSLAGWKPSV--------YHVLLILGLFAVLLSCCASAMYTSVEGWDYVDSLYFCFVTFSTIG 258

  Fly   285 FGDLVPKKPN-------YMLLCTLYILIGL----ALTSTIIELVRRQYATSWAKLQELS------ 332
            |||||..:..       |.|...|:||:|:    :|.:.|..|:::  ..:| .|::||      
Human   259 FGDLVSSQHAAYRNQGLYRLGNFLFILLGVCCIYSLFNVISILIKQ--VLNW-MLRKLSCRCCAR 320

  Fly   333 ---GPMAETLRRLGETAGTGL--------------DYTALQKVLT---VSMPKWNSKKNEHSPDI 377
               .|.|...||...|.|:.|              |..|..:.|:   :||           .|:
Human   321 CCPAPGAPLARRNAITPGSRLRRRLAALGADPAARDSDAEGRRLSGELISM-----------RDL 374

  Fly   378 AALEAITNAIL-KEVKEAQNNKPK 400
            .|...::.|:| |::.|..|..|:
Human   375 TASNKVSLALLQKQLSETANGYPR 398

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG43155NP_572720.2 Ion_trans_2 143..214 CDD:462301 24/93 (26%)
Ion_trans_2 <267..319 CDD:462301 24/62 (39%)
KCNK12NP_071338.1 ER retention/retrieval signal. /evidence=ECO:0000269|PubMed:24163367 11..16
Ion_trans_2 100..169 CDD:462301 25/78 (32%)
Selectivity filter 1. /evidence=ECO:0000250|UniProtKB:P57789 129..134 3/4 (75%)
Ion_trans_2 222..304 CDD:462301 27/81 (33%)
Selectivity filter 2. /evidence=ECO:0000250|UniProtKB:P57789 256..261 4/4 (100%)
Blue background indicates that the domain is not in the aligned region.

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