DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG43155 and kcnk18

DIOPT Version :9

Sequence 1:	NP_572720.2	Gene:	CG43155 / 32092	FlyBaseID:	FBgn0262685	Length:	411	Species:	Drosophila melanogaster
Sequence 2:	NP_001177236.2	Gene:	kcnk18 / 561821	ZFINID:	ZDB-GENE-100405-2	Length:	391	Species:	Danio rerio

Alignment Length:	384	Identity:	93/384 - (24%)
Similarity:	146/384 - (38%)	Gaps:	139/384 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 GRRSTACWQSMKWKSALNHIGLLVSLSIYCGVGGLIFRHLERPAEVERLSHLKDIVKTHRERFLH 111
            ||.||..|:      ...|:.|::||.:|..:|.|:||.:|..........:..||    ::.:.
Zfish    11 GRCSTLFWR------LFPHVFLILSLVLYAVLGALVFRAIEYTNPRNESEEILSIV----QKVME 65

  Fly   112 TILNNTEVHNLDELLSFELAKYEAAVQQAAEGGLLIVADKDFPEPYER---WSILQAVFFSSTVL 173
            .:.|:|:......|::  .|||              :.| |:....||   |:...::||..||.
Zfish    66 IVQNHTDASEQKHLIN--KAKY--------------ILD-DYCYEKERDHGWTFFASLFFCCTVF 113

  Fly   174 TTIGYGNIVPVTTGGRVFCICFALIGIPFTLTVIADWGRLFATAVS------------------- 219
            ||:|||.|.|:|:.|:|.|:.:|::|||..|.||:|.|.|.|..:|
Zfish   114 TTVGYGRIYPLTSKGKVACVLYAMVGIPLMLLVISDVGDLLAVLLSKAYTRLNLFFRRWIGHQSW 178

  Fly   220 ----------------------------------------------------------VFGK--- 223
                                                                      :|.:
Zfish   179 RLQSHEKTSALPQAQADTDGTYKFNQDVVVLETTNNQQVIQTRSSIRRGSFQLRNNKEIFDRIIV 243

  Fly   224 --------------------HMPT-KPKFTNFIGKTW------FYAILAVGFLGVYLAAGAGLLL 261
                                .:|| |.:..|.||:..      ...||.:.|  .|:...:.:|.
Zfish   244 RESFRIKGTLSKSCSCPELDRVPTPKDELFNDIGQEMEQLDVPLLVILLMVF--AYMVICSQILK 306

  Fly   262 LWEDDWTFFDGFYFCFITMTTIGFGDLVPKKPNYMLLCTLYILIGLALTSTIIELVRRQ 320
            .||......|.|||.|||:|||||||:||:.|.:.::..|:|:.|:|:.|...:|.:.|
Zfish   307 CWEKQMDHSDAFYFTFITLTTIGFGDIVPEHPKFFMVTFLFIITGMAIMSMAFKLGQSQ 365

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43155	NP_572720.2	Ion_trans_2	<157..214	CDD:285168	27/59 (46%)
		Ion_trans	<240..314	CDD:278921	29/73 (40%)
		Ion_trans_2	<266..319	CDD:285168	23/52 (44%)
kcnk18	NP_001177236.2	Ion_trans_2	<99..154	CDD:285168	25/54 (46%)
kcnk18	NP_001177236.2	Ion_trans_2	292..367	CDD:285168	29/76 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170590189
Domainoid	1	1.000	63	1.000	Domainoid score	I10236
eggNOG	1	0.900	-	-		E1_KOG1418
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D542195at33208
OrthoFinder	1	1.000	-	-		FOG0000030
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11003
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.850