Protein Alignment CG43155 and KCNK9

DIOPT Version :10

• Sequence 1: NP_572720.2
• Gene: CG43155 / 32092
• FlyBaseID: FBgn0262685
• Length: 411
• Species: Drosophila melanogaster
• Sequence 2: NP_001269463.1
• Gene: KCNK9 / 51305
• HGNCID: 6283
• Length: 374
• Species: Homo sapiens
• Alignment Length: 275
• Identity: 81/275 - (29%)
• Similarity: 119/275 - (43%)
• Gaps: 52/275 - (18%)

  Fly    66 IGLLVSLSIYCGVGGLIFRHLERPAEVERLSHLKDIVKTHRERFLHTILNNTEVHNLDELLSFEL 130
            :.|:|....|..||..:|..||...|:.....||  .:..|.:..:.|  ::|.:...||:..:.
Human     9 LSLIVCTFTYLLVGAAVFDALESDHEMREEEKLK--AEEIRIKGKYNI--SSEDYRQLELVILQS 69

  Fly   131 AKYEAAVQQAAEGGLLIVADKDFPEPYERWSILQAVFFSSTVLTTIGYGNIVPVTTGGRVFCICF 195
            ..:.|.||                     |....:.:|:.||:||||||:..|.|..|:.||:.:
Human    70 EPHRAGVQ---------------------WKFAGSFYFAITVITTIGYGHAAPGTDAGKAFCMFY 113

  Fly   196 ALIGIPFTLTVIADWGRLFATAVSVFGKHMP-------TKPKFTNFIGKTWFYAILAVGFLGVY- 252
            |::|||.||.:....|....|.|....|.:.       |.....|.:         .|||....
Human   114 AVLGIPLTLVMFQSLGERMNTFVRYLLKRIKKCCGMRNTDVSMENMV---------TVGFFSCMG 169

  Fly   253 -LAAGAGLLLLWEDDWTFFDGFYFCFITMTTIGFGDLV--------PKKPNYMLLCTLYILIGLA 308
             |..||......| :|:||..:|:||||:|||||||.|        .|||.|:....:|||:||.
Human   170 TLCIGAAAFSQCE-EWSFFHAYYYCFITLTTIGFGDYVALQTKGALQKKPLYVAFSFMYILVGLT 233

  Fly   309 LTSTIIELVRRQYAT 323
            :....:.||..::.|
Human   234 VIGAFLNLVVLRFLT 248

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43155	NP_572720.2	Ion_trans_2	143..214	CDD:462301	22/70 (31%)
		Ion_trans_2	<267..319	CDD:462301	27/59 (46%)
KCNK9	NP_001269463.1	Ion_trans_2	<73..132	CDD:462301	25/79 (32%)
		Selectivity filter 1. /evidence=ECO:0000305|PubMed:26919430	93..98		4/4 (100%)
		Ion_trans_2	<183..243	CDD:462301	26/59 (44%)
		Selectivity filter 2. /evidence=ECO:0000305|PubMed:26919430	199..204		4/4 (100%)
		X-gate. /evidence=ECO:0000269|PubMed:38630723	243..248		0/4 (0%)