DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG43155 and Kcnk18

DIOPT Version :9

Sequence 1:	NP_572720.2	Gene:	CG43155 / 32092	FlyBaseID:	FBgn0262685	Length:	411	Species:	Drosophila melanogaster
Sequence 2:	NP_001003820.1	Gene:	Kcnk18 / 445371	RGDID:	1303091	Length:	405	Species:	Rattus norvegicus

Alignment Length:	411	Identity:	98/411 - (23%)
Similarity:	151/411 - (36%)	Gaps:	133/411 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 EGGGLAKG---TAGGRRSTACWQSMKWKSALNHIGLLVSLSIYCGVGGLIFRHLE-RP-AEVERL 95
            |..|.|.|   .|.|:....|.:::  ...|..:..|..|..|..||..:|..:| || .|.|..
  Rat    15 EALGKASGCCPEAPGKARGCCPEAL--GKLLPGLCFLCCLVTYALVGAALFSAVEGRPDPEAEEN 77

  Fly    96 SHLKDIVKTHRERFLHTILNNTEVHNLDELLSFELAKYEAAVQQAAEGGLLIVADKDFPEPYERW 160
            ..||        :||..:.|         :|...|...|.:.:...| .|..:..:.|..| |.|
  Rat    78 PELK--------KFLDKLCN---------ILKCNLTVVEGSRKDLCE-HLQQLKPQWFKAP-EDW 123

  Fly   161 SILQAVFFSSTVLTTIGYGNIVPVTTGGRVFCICFALIGIPFTLTVIADWGRLFATAVS------ 219
            |.|.|:||..||.:|:|||::.|||..|:..|:.:||.|||....|:.|.|.:.|..:|
  Rat   124 SFLSALFFCCTVFSTVGYGHMYPVTRLGKFLCMLYALFGIPLMFLVLTDIGDILAAILSRAYSRF 188

  Fly   220 -----------------VFGKHMPTKPK----------------------------------FTN 233
                             :..|...:||.                                  |..
  Rat   189 QALLCLPRDISKWRPLLLCRKQTDSKPADEAIPQIVIDAGADELLDPQPSREPASPSCNVELFER 253

  Fly   234 FIGKTWFYAI---------------LAVGFLG-----------------------------VYLA 254
            .:.:.....:               |.:|.|.                             .|::
  Rat   254 LVAREKQNELQPPMRPVERSNSCPELVLGRLSCSILSNLDEVGQQVERLDIPLPVIALVIFAYIS 318

  Fly   255 AGAGLLLLWEDDWTFFDGFYFCFITMTTIGFGDLVPKKPNYMLLCTLYILIGLALTSTIIELVRR 319
            ..|.:|..||.|..|.|.|||||:|:|||||||:|...|::.|..::||::|:.:.....:|::.
  Rat   319 CAAAILPFWETDLGFEDAFYFCFVTLTTIGFGDIVLVHPHFFLFFSIYIIVGMEILFIAFKLMQN 383

  Fly   320 QYATSWAKL------QELSGP 334
            :...::..|      :|:|.|
  Rat   384 RLLHTYKTLMLFVCQREVSLP 404

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43155	NP_572720.2	Ion_trans_2	<157..214	CDD:285168	26/56 (46%)
		Ion_trans	<240..314	CDD:278921	30/117 (26%)
		Ion_trans_2	<266..319	CDD:285168	23/52 (44%)
Kcnk18	NP_001003820.1	Ion_trans_2	116..177	CDD:285168	28/61 (46%)
		Interaction with calcineurin. /evidence=ECO:0000250	221..226		0/4 (0%)
		Interaction with YWHAH. /evidence=ECO:0000250	272..277		0/4 (0%)
		Ion_trans_2	311..387	CDD:285168	28/75 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348989
Domainoid	1	1.000	69	1.000	Domainoid score	I9436
eggNOG	1	0.900	-	-		E1_KOG1418
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D542195at33208
OrthoFinder	1	1.000	-	-		FOG0000030
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11003
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.850