Protein Alignment CG43155 and Kcnf1

DIOPT Version :10

• Sequence 1: NP_572720.2
• Gene: CG43155 / 32092
• FlyBaseID: FBgn0262685
• Length: 411
• Species: Drosophila melanogaster
• Sequence 2: NP_963289.3
• Gene: Kcnf1 / 382571
• MGIID: 2687399
• Length: 493
• Species: Mus musculus
• Alignment Length: 442
• Identity: 104/442 - (23%)
• Similarity: 149/442 - (33%)
• Gaps: 150/442 - (33%)

  Fly     1 MPMKKVTVKEYDSQDEASTELLEK---LKHLDRR---------VDAAEGGGLAKGTAGGRRSTAC 53
            |...||.:|..|  |...:.|.||   |:.:.||         ||||||           |...|
Mouse   113 MDFWKVDLKFLD--DCCKSHLSEKREELEEIARRVQLILDDLGVDAAEG-----------RWRRC 164

  Fly    54 WQSMKWK--------------SALNHIGLLVSLSIYCGVGGLIFRHLERPAEVERLSHLKDIVKT 104
             |...||              :.|:.:.:|||..:.| :|.:        .|::       :|.:
Mouse   165 -QKCVWKFLEKPESSCPARVVAVLSFLLILVSSVVMC-MGTI--------PELQ-------VVDS 212

  Fly   105 HRERFLHTILNNTEV-----HNLDELLSFELAKYEAAVQQAAEGGLLIVADKDFPEP---YERWS 161
            ...|..|..|.|.|.     ..|:.||..                        |..|   :...|
Mouse   213 EGNRVEHPTLENVETACIGWFTLEYLLRL------------------------FSSPNKLHFALS 253

  Fly   162 ILQAV-------FFSSTVLTTIG-----YGNIVPVTTGGRVFCICFALIGIPFTLTVIADWGRLF 214
            .:..|       |:.|..||.:|     ..|:.......|:..|                 .|:|
Mouse   254 FMNIVDVLAILPFYVSLTLTHLGARMMELTNVQQAVQALRIMRI-----------------ARIF 301

  Fly   215 ATAVSVFGKHMPTKPKFTNF--IGKTWFYAILAVGFLGVYLAAGAGLLLLWEDDWTFF----DGF 273
            ..|....|....|.....:|  :|....|  |||   |:::.:..|..:......|.|    ..|
Mouse   302 KLARHSSGLQTLTYALKRSFKELGLLLMY--LAV---GIFVFSALGYTMEQSHPETLFKSIPQSF 361

  Fly   274 YFCFITMTTIGFGDLVPK----KPNYML--LCTLYILIGLALTSTIIELVR---RQYATSWA--- 326
            ::..|||||:|:||:.||    |.|..:  ||.: |.|.|.:...|...||   :|.....|
Mouse   362 WWAIITMTTVGYGDIYPKTTLGKLNAAISFLCGV-IAIALPIHPIINNFVRYYNKQRVLETAAKH 425

  Fly   327 --KLQELSGPMAETLRRLGETAGTGLDYTAL-QKVLTVSMPKWNSK-KNEHS 374
              :|.||:...||     |:..|:..|...| .:......|.|.|: |..||
Mouse   426 ELELMELNSSSAE-----GKPGGSRSDLDTLPPEPAAREGPSWGSRLKLSHS 472

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43155	NP_572720.2	Ion_trans_2	143..214	CDD:462301	13/85 (15%)
		Ion_trans_2	<267..319	CDD:462301	23/64 (36%)
Kcnf1	NP_963289.3	BTB_POZ_Kv5_KCNF1	23..138	CDD:349690	9/26 (35%)
		Ion_trans	181..417	CDD:459842	64/298 (21%)
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142	370..375		2/4 (50%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	434..468		9/38 (24%)