DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG43155 and KCNQ2

DIOPT Version :9

Sequence 1:	NP_572720.2	Gene:	CG43155 / 32092	FlyBaseID:	FBgn0262685	Length:	411	Species:	Drosophila melanogaster
Sequence 2:	NP_001369164.1	Gene:	KCNQ2 / 3785	HGNCID:	6296	Length:	890	Species:	Homo sapiens

Alignment Length:	403	Identity:	83/403 - (20%)
Similarity:	134/403 - (33%)	Gaps:	137/403 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 TVKEYDSQDEASTELLE-----------------------------KLKH-------LDRRVDAA 35
            |:|||:...|.:..:||                             :||.       :|..|..|
Human   114 TIKEYEKSSEGALYILEIVTIVVFGVEYFVRIWAAGCCCRYRGWRGRLKFARKPFCVIDIMVLIA 178

  Fly    36 EGGGLAKGTAGGRRSTACWQSMKWKSALNHIGLLVSLSIYCGVGGLIFRHLERPAEVERLSHLKD 100
            ....||.|:.|...:|:..:|:::...|..|.:......:..:|.:::            :|.|:
Human   179 SIAVLAAGSQGNVFATSALRSLRFLQILRMIRMDRRGGTWKLLGSVVY------------AHSKE 231

  Fly   101 IVKTHRERFLHTILNNTEVHNLDELLSFELAKYEAAVQQAAEGGLLIVADKDFPEPYERWSILQA 165
            :|......||..|           |.||                |:.:|:|...:.::.::  .|
Human   232 LVTAWYIGFLCLI-----------LASF----------------LVYLAEKGENDHFDTYA--DA 267

  Fly   166 VFFSSTVLTTIGYGNIVPVTTGGRVFCICFALIGIPFTLTVIADWGRLFATAVSVFG-------- 222
            :::....|||||||:..|.|..||:....|.|||:.|           ||....:.|
Human   268 LWWGLITLTTIGYGDKYPQTWNGRLLAATFTLIGVSF-----------FALPAGILGSGFALKVQ 321

  Fly   223 -----KHMPTKPK-FTNFIGKTW-FYAILAVGFLGVYLAAGAGLLLLWEDDWTFFDGFYFCFITM 280
                 ||...:.. ....|...| |||.         ..:...|...|:        :|...:|:
Human   322 EQHRQKHFEKRRNPAAGLIQSAWRFYAT---------NLSRTDLHSTWQ--------YYERTVTV 369

  Fly   281 -------TTIGFGDLVPKKPNYMLLCTLYILIGLAL---------TSTIIELVRRQYATSWAKLQ 329
                   .|.|...|:|......||..|....|||.         .|..:.|..|.:::......
Human   370 PMYSSQTQTYGASRLIPPLNQLELLRNLKSKSGLAFRKDPPPEPSPSQKVSLKDRVFSSPRGVAA 434

  Fly   330 ELSG-PMAETLRR 341
            :..| |.|:|:||
Human   435 KGKGSPQAQTVRR 447

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43155	NP_572720.2	Ion_trans_2	<157..214	CDD:285168	17/56 (30%)
		Ion_trans	<240..314	CDD:278921	18/89 (20%)
		Ion_trans_2	<266..319	CDD:285168	14/68 (21%)
KCNQ2	NP_001369164.1	Ion_trans	92..324	CDD:395416	53/261 (20%)
		KCNQ_channel	448..669	CDD:397540	83/403 (21%)
		KCNQ2_u3	684..774	CDD:406935
		KCNQC3-Ank-G_bd	786..886	CDD:403240
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D774951at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.010