DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG43155 and KCNK2

DIOPT Version :9

Sequence 1:NP_572720.2 Gene:CG43155 / 32092 FlyBaseID:FBgn0262685 Length:411 Species:Drosophila melanogaster
Sequence 2:NP_001017425.2 Gene:KCNK2 / 3776 HGNCID:6277 Length:426 Species:Homo sapiens


Alignment Length:329 Identity:92/329 - (27%)
Similarity:149/329 - (45%) Gaps:81/329 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    57 MKWKSALNHIGLLVSLSIYCGVGGLIFRHLERPAEVERLSHLKDIVKTHRERFL--HTILNNTEV 119
            ||||: ::.|.|:|.|  |..:|..:|:.||:|.|:.:    :..:...::.|:  |:.:|:|| 
Human    57 MKWKT-VSTIFLVVVL--YLIIGATVFKALEQPHEISQ----RTTIVIQKQTFISQHSCVNSTE- 113

  Fly   120 HNLDELLSFELAKYEAAVQQAAEGGLLIVADKDFPEPYERWSILQAVFFSSTVLTTIGYGNIVPV 184
              ||||:.        .:..|...|::.:.:..  .....|.:..:.||:.||:||||:|||.|.
Human   114 --LDELIQ--------QIVAAINAGIIPLGNTS--NQISHWDLGSSFFFAGTVITTIGFGNISPR 166

  Fly   185 TTGGRVFCICFALIGIPFTLTVIADWGRLFATAVSVFGKHM-------------PTKPKFTNFI- 235
            |.||::|||.:||:|||....::|..|....|   :|||.:             .||.:..:.| 
Human   167 TEGGKIFCIIYALLGIPLFGFLLAGVGDQLGT---IFGKGIAKVEDTFIKWNVSQTKIRIISTII 228

  Fly   236 ----GKTWFYAILAVGFLGVYLAAGAGLLLLWEDDWTFFDGFYFCFITMTTIGFGDLVPKKPN-- 294
                |...|.|:.|:.|..:             :.|:..|..||..||:|||||||.|....:  
Human   229 FILFGCVLFVALPAIIFKHI-------------EGWSALDAIYFVVITLTTIGFGDYVAGGSDIE 280

  Fly   295 ----YMLLCTLYILIGLALTSTIIELVR-----------------RQYATSWAKLQELSGPMAET 338
                |..:...:||:|||..:.::.::.                 |.:|..|.  ..::....||
Human   281 YLDFYKPVVWFWILVGLAYFAAVLSMIGDWLRVISKKTKEEVGEFRAHAAEWT--ANVTAEFKET 343

  Fly   339 LRRL 342
            .|||
Human   344 RRRL 347

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG43155NP_572720.2 Ion_trans_2 <157..214 CDD:285168 26/56 (46%)
Ion_trans <240..314 CDD:278921 24/79 (30%)
Ion_trans_2 <266..319 CDD:285168 20/75 (27%)
KCNK2NP_001017425.2 Ion_trans_2 <142..196 CDD:400301 26/53 (49%)
Ion_trans_2 234..312 CDD:400301 24/90 (27%)
Required for basal channel activity. /evidence=ECO:0000250 354..426
Essential for chloroform and halothane sensitivity. /evidence=ECO:0000250 378..426
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1418
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000030
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11003
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X19
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
65.910

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