Protein Alignment CG43155 and KCNK1

DIOPT Version :9

• Sequence 1: NP_572720.2
• Gene: CG43155 / 32092
• FlyBaseID: FBgn0262685
• Length: 411
• Species: Drosophila melanogaster
• Sequence 2: NP_002236.1
• Gene: KCNK1 / 3775
• HGNCID: 6272
• Length: 336
• Species: Homo sapiens
• Alignment Length: 357
• Identity: 97/357 - (27%)
• Similarity: 157/357 - (43%)
• Gaps: 83/357 - (23%)

  Fly    68 LLVSLSIYCGVGGLIFRHLERPAEVERLSHLKDIVKTHRERFL--HTILNNTEVHNLDELLS--F 128
            |::...:|...|.::|..:|.|.|    ..|:..::..:.|||  |..|:..:   |::.|.  .
Human    26 LVLGYLLYLVFGAVVFSSVELPYE----DLLRQELRKLKRRFLEEHECLSEQQ---LEQFLGRVL 83

  Fly   129 ELAKYEAAVQQAAEGGLLIVADKDFPEPYERWSILQAVFFSSTVLTTIGYGNIVPVTTGGRVFCI 193
            |.:.|..:|...|.|..             .|....|:||:||||:|.|||:.||::.||:.|||
Human    84 EASNYGVSVLSNASGNW-------------NWDFTSALFFASTVLSTTGYGHTVPLSDGGKAFCI 135

  Fly   194 CFALIGIPFTLTVIADWGRLFATA-VSVFGKHMPTKPKFTNFIGKTW---------FYAILAVGF 248
            .:::|||||||        ||.|| |.....|:..:|..  :....|         .:|:| :||
Human   136 IYSVIGIPFTL--------LFLTAVVQRITVHVTRRPVL--YFHIRWGFSKQVVAIVHAVL-LGF 189

  Fly   249 LGV--YLAAGAGLLLLWEDDWTFFDGFYFCFITMTTIGFGDLVPK-------KPNYMLLCTLYIL 304
            :.|  :....|.:..:.||||.|.:.||||||:::|||.||.||.       :..|.:..|.|:|
Human   190 VTVSCFFFIPAAVFSVLEDDWNFLESFYFCFISLSTIGLGDYVPGEGYNQKFRELYKIGITCYLL 254

  Fly   305 IGLALTSTIIELVRRQYATSWAKLQELSGPMAETLRRLGETAGTGLDYTALQKVLTVSMPKWNSK 369
            :||.....::|        ::.:|.||.                     ..:|:..|...|...:
Human   255 LGLIAMLVVLE--------TFCELHELK---------------------KFRKMFYVKKDKDEDQ 290

  Fly   370 KNEHSPDIAALEAITNAILKEVKEAQNNKPKV 401
            .:....|..:..:||:......::.:.|:|.|
Human   291 VHIIEHDQLSFSSITDQAAGMKEDQKQNEPFV 322

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43155	NP_572720.2	Ion_trans_2	<157..214	CDD:285168	26/56 (46%)
		Ion_trans	<240..314	CDD:278921	30/82 (37%)
		Ion_trans_2	<266..319	CDD:285168	23/59 (39%)
KCNK1	NP_002236.1	Ion_trans_2	<101..157	CDD:400301	31/63 (49%)
		pore-forming domain	107..123		11/15 (73%)
		Ion_trans_2	192..267	CDD:400301	27/82 (33%)
		pore-forming domain	212..238		14/25 (56%)
		Important for intracellular retention in recycling endosomes. /evidence=ECO:0000269|PubMed:19959478	293..299		1/5 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1418
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000030
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4331
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.840