DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG43155 and twk-43

DIOPT Version :9

Sequence 1:	NP_572720.2	Gene:	CG43155 / 32092	FlyBaseID:	FBgn0262685	Length:	411	Species:	Drosophila melanogaster
Sequence 2:	NP_872137.2	Gene:	twk-43 / 3565024	WormBaseID:	WBGene00006693	Length:	597	Species:	Caenorhabditis elegans

Alignment Length:	360	Identity:	101/360 - (28%)
Similarity:	158/360 - (43%)	Gaps:	95/360 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 KWKSALNHIGLLVSLSIYCGVGGLIFRHLER-PAEVERLSHLK-----DIVKTHRERFLHTIL-- 114
            |:|..|.:.|:::.:.||...|.|:.:::|| |.:||....|:     |:.....:|....:|
Worm    34 KFKPYLLNAGIVLFVGIYVYAGALLIQYIERIPVKVEESFRLRRNSQDDMPIIPLDRSKECVLQA 98

  Fly   115 ----------NNTEVHN----LDELLSFELAKYEAAVQQAAEGGLL-----IVADKDF--PEPYE 158
                      |.:::||    |:...:.:|.|.: .:..::||...     .||.|.|  .:.:|
Worm    99 LRKMSQISKGNCSQLHNNVNLLENCYASDLQKLK-TIYDSSEGSKAPEQQSAVALKKFVIVDGFE 162

  Fly   159 RWSILQAVFFSSTVLTTIGYGNIVPVTTGGRVFCICFALIGIP-----------FTLTVIADWGR 212
            :|:...|:.|..||:|||||||:.|.:..||||.|.:..||||           |..|::..|.|
Worm   163 QWTTTDAILFCFTVITTIGYGNVAPQSFWGRVFVIIYGTIGIPTAMMAIANVGKFLATLLKSWTR 227

  Fly   213 LFATAVSVFGKHMPTKPKFTNFIGKTWFY-----------------------------------A 242
            .|........|.|..|.:..|.|.:|...                                   .
Worm   228 PFLLLCRKMKKRMQKKDQNGNEIKETQRLMESSKKKAKKIEDDISSHEDEEAEEEVEESDVTETI 292

  Fly   243 ILAVGFLGVYLAAGAGLLLLWEDDWTFFDGFYFCFITMTTIGFGDLVPKKPNYMLLCTLYILIGL 307
            :|.|.|| ||:.||:.|:..:|:..||....||.|:|:||||.|||||:..:::.:..:|..|||
Worm   293 VLFVAFL-VYIIAGSLLMSYYEEGMTFGLAIYFNFVTLTTIGLGDLVPQSTDWLFVTLVYCAIGL 356

  Fly   308 ALTSTIIELVRRQYATSWAKLQELSGPMAETLRRL 342
            |||:..||:.                  |:||::|
Worm   357 ALTTIAIEIA------------------ADTLKKL 373

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43155	NP_572720.2	Ion_trans_2	<157..214	CDD:285168	27/67 (40%)
		Ion_trans	<240..314	CDD:278921	32/108 (30%)
		Ion_trans_2	<266..319	CDD:285168	24/52 (46%)
twk-43	NP_872137.2	Ion_trans_2	<162..218	CDD:285168	23/55 (42%)
twk-43	NP_872137.2	Ion_trans_2	298..372	CDD:285168	35/92 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11003
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	5	4.970