Protein Alignment CG43155 and KCNK18

DIOPT Version :9

• Sequence 1: NP_572720.2
• Gene: CG43155 / 32092
• FlyBaseID: FBgn0262685
• Length: 411
• Species: Drosophila melanogaster
• Sequence 2: NP_862823.1
• Gene: KCNK18 / 338567
• HGNCID: 19439
• Length: 384
• Species: Homo sapiens
• Alignment Length: 359
• Identity: 90/359 - (25%)
• Similarity: 136/359 - (37%)
• Gaps: 131/359 - (36%)

  Fly    69 LVSLSIYCGVGGLIFRHLERPAEVERLSHLKDIVKTHRERFLH---TILNNTEVHNLDELLSFEL 130
            |..|..|..||.::|..:|   :.:.|....|   ...|:||.   .|||.:|....|.
Human    27 LCFLVTYALVGAVVFSAIE---DGQVLVAADD---GEFEKFLEELCRILNCSETVVEDR------ 79

  Fly   131 AKYEAAVQQAAEGGLLIVADKDFPEPYER---WSILQAVFFSSTVLTTIGYGNIVPVTTGGRVFC 192
                   :|..:|.|    .|..|:.:.|   ||.|.::||..||.:|:|||.|.|||..|:..|
Human    80 -------KQDLQGHL----QKVKPQWFNRTTHWSFLSSLFFCCTVFSTVGYGYIYPVTRLGKYLC 133

  Fly   193 ICFALIGIPFTLTVIADWGRLFATAVSV----FGKHMP--TKPKFTNFIGKTWF----------- 240
            :.:||.|||....|:.|.|.:.||.:|.    |.| .|  |:|..:.:..|:.|
Human   134 MLYALFGIPLMFLVLTDTGDILATILSTSYNRFRK-FPFFTRPLLSKWCPKSLFKKKPDPKPADE 197

  Fly   241 ----------------------------------------------------------------- 240
                                                                             
Human   198 AVPQIIISAEELPGPKLGTCPSRPSCSMELFERSHALEKQNTLQLPPQAMERSNSCPELVLGRLS 262

  Fly   241 YAILA----VG---------------FLGVYLAAGAGLLLLWEDDWTFFDGFYFCFITMTTIGFG 286
            |:|::    ||               .:..|::..|.:|..||....|.:.|||||:|:||||||
Human   263 YSIISNLDEVGQQVERLDIPLPIIALIVFAYISCAAAILPFWETQLDFENAFYFCFVTLTTIGFG 327

  Fly   287 DLVPKKPNYMLLCTLYILIGLALTSTIIELVRRQ 320
            |.|.:.||:.|..::||::|:.:.....:||:.:
Human   328 DTVLEHPNFFLFFSIYIIVGMEIVFIAFKLVQNR 361

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43155	NP_572720.2	Ion_trans_2	<157..214	CDD:285168	26/59 (44%)
		Ion_trans	<240..314	CDD:278921	31/168 (18%)
		Ion_trans_2	<266..319	CDD:285168	23/52 (44%)
KCNK18	NP_862823.1	Ion_trans_2	<100..155	CDD:285168	25/54 (46%)
		Interaction with calcineurin. /evidence=ECO:0000250	200..205		0/4 (0%)
		Interaction with YWHAH. /evidence=ECO:0000250	249..254		0/4 (0%)
		Ion_trans_2	288..364	CDD:285168	28/74 (38%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155113
Domainoid	1	1.000	69	1.000	Domainoid score	I9675
eggNOG	1	0.900	-	-		E1_KOG1418
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D542195at33208
OrthoFinder	1	1.000	-	-		FOG0000030
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11003
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.850