Protein Alignment CG43155 and KCNV1

DIOPT Version :10

• Sequence 1: NP_572720.2
• Gene: CG43155 / 32092
• FlyBaseID: FBgn0262685
• Length: 411
• Species: Drosophila melanogaster
• Sequence 2: NP_055194.1
• Gene: KCNV1 / 27012
• HGNCID: 18861
• Length: 500
• Species: Homo sapiens
• Alignment Length: 461
• Identity: 96/461 - (20%)
• Similarity: 157/461 - (34%)
• Gaps: 155/461 - (33%)

  Fly    25 LKHLDRRVDAAEGGG--LAKG-----TAGGRRSTACWQSMKWKSALNH--IG-LLVSLSIYCGVG 79
            |..||..|..:||.|  ||.|     ..||.|.....|::   |...|  :| |.|.::.|...|
Human    18 LTSLDSSVFCSEGEGEPLALGDCFTVNVGGSRFVLSQQAL---SCFPHTRLGKLAVVVASYRRPG 79

  Fly    80 GLIFRHLERPAEV-------------ERLSH-LKDIVKTHRERFLH--------TILNNTEVHNL 122
            .|  ..:..|.|:             :|.|. .:.::..:|...||        :.|...:...:
Human    80 AL--AAVPSPLELCDDANPVDNEYFFDRSSQAFRYVLHYYRTGRLHVMEQLCALSFLQEIQYWGI 142

  Fly   123 DEL-------------------LSFELAKYEAAVQQAAEGGLLIVADKDF---PEPYER---WSI 162
            |||                   |.|:....:...|..:|        :||   |.|..|   |:|
Human   143 DELSIDSCCRDRYFRRKELSETLDFKKDTEDQESQHESE--------QDFSQGPCPTVRQKLWNI 199

  Fly   163 LQAVFFSSTVLTTIGYGNIVPVT--------------------------------TGG---RVFC 192
            |:.. .|||.....|..:|:.|.                                ||.   |..|
Human   200 LEKP-GSSTAARIFGVISIIFVVVSIINMALMSAELSWLDLQLLEILEYVCISWFTGEFVLRFLC 263

  Fly   193 I---C---------FALIGI-PFTLTVIAD-------------WGR-------LFATAVSVFGKH 224
            :   |         ..|:.| ||.:|::.:             .||       |.|..:...|:|
Human   264 VRDRCRFLRKVPNIIDLLAILPFYITLLVESLSGSQTTQELENVGRIVQVLRLLRALRMLKLGRH 328

  Fly   225 MPTKPKFTNFIGKTWFYAILAVGFLGVYLAAGAGLLLLWE-------DDWTFFD---GFYFCFIT 279
            ...    ...:|.|.......||.|.::|:.|..:....|       .|.||..   .:::...:
Human   329 STG----LRSLGMTITQCYEEVGLLLLFLSVGISIFSTVEYFAEQSIPDTTFTSVPCAWWWATTS 389

  Fly   280 MTTIGFGDLVPKKPNYMLLCTLYILIGLALTSTIIELVRRQYATSW--AKLQELSGPMAETLRRL 342
            |||:|:||:.|......::..:.||.|:.:.:..|.::..:::..:  .||:|.:....|.|::|
Human   390 MTTVGYGDIRPDTTTGKIVAFMCILSGILVLALPIAIINDRFSACYFTLKLKEAAVRQREALKKL 454

  Fly   343 GETAGT 348
            .:...|
Human   455 TKNIAT 460

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43155	NP_572720.2	Ion_trans_2	143..214	CDD:462301	26/144 (18%)
		Ion_trans_2	<267..319	CDD:462301	13/54 (24%)
KCNV1	NP_055194.1	BTB_POZ	41..160	CDD:453885	23/123 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	168..189		4/28 (14%)
		Ion_trans	209..435	CDD:459842	41/229 (18%)
		Selectivity filter. /evidence=ECO:0000250	392..397		2/4 (50%)