DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG43155 and twk-4

DIOPT Version :9

Sequence 1:	NP_572720.2	Gene:	CG43155 / 32092	FlyBaseID:	FBgn0262685	Length:	411	Species:	Drosophila melanogaster
Sequence 2:	NP_001343566.1	Gene:	twk-4 / 192079	WormBaseID:	WBGene00006659	Length:	418	Species:	Caenorhabditis elegans

Alignment Length:	418	Identity:	115/418 - (27%)
Similarity:	188/418 - (44%)	Gaps:	87/418 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 STELLEKLKHLD-------RRVDAAEGGGLAK---GTAGGRRSTACWQS--------------MK 58
            :|..|....|.|       ||..:::.|.:.:   |||..||..|....              ..
Worm    20 TTTALISRNHSDWAHLQLLRRTPSSDAGNMNQIHFGTASARRRNAMILENNSGDEDAPKQGFLAN 84

  Fly    59 WKSALNHIGLLVSLSIYCGVGGLIFRHLERPAEVERLSHLKDIVKTHRERFLHTILNNTEVHNLD 123
            .:.||.|:.|:.:...|...|..:|..:|..||::|.            :..|||..|. ::||.
Worm    85 LRLALFHLVLIFATVAYIIAGAYLFTKIEHQAELDRY------------QSYHTIYRNF-INNLY 136

  Fly   124 ELLSFELAKYEAAVQ-------QAAEGGLLIVADKDF--PEPYERWSILQAVFFSSTVLTTIGYG 179
            :..:..:|..|..:.       :|.:.||   ...||  |:...|||::.|:||::||||:||||
Worm   137 QSSNRSVADVENLIDTFTSINFRAFKEGL---KPTDFLVPQETSRWSMISAIFFTTTVLTSIGYG 198

  Fly   180 NIVPVTTGGRVFCICFALIGIPFTLTVIADWGRLFATAVSVFGKHMPTK-PKFTNFIGKTWFYAI 243
            |::|::|||::||:.:|:.|||.||..|||..:..|..:.:    .||: ||    .|:    .:
Worm   199 NLIPISTGGKIFCVGYAIFGIPLTLVTIADLAKFVADMLIM----DPTEDPK----TGR----QL 251

  Fly   244 LAVGFLGVYLAAGAGLLLLWEDDWTFFDGFYFCFITMTTIGFGDLVP-KKPNYMLLCTLYILIGL 307
            |.:.||..|:...|.:..:.|..|:|.|.||||.:::.|:|||||.| ....|||...::|.|||
Worm   252 LVLVFLLGYMTISACVYTILEPMWSFLDSFYFCLVSLLTVGFGDLHPVGTVEYMLCSIVFIFIGL 316

  Fly   308 ALTSTIIELVRRQYATSWAKLQELSGPMAETLRRLGETAGTGLDYTALQKVLTVSMPKWNSKKNE 372
            .||:..:::   ..:...||:..:               |.|.|...:...|.|...::.:|
Worm   317 ILTTLAVDV---SGSVGIAKMHSI---------------GRGFDAMKMLNALRVRKSEFVAK--- 360

  Fly   373 HSPDIAALEAITNAILKEVKEAQNNKPK 400
               ...:|.|......:.:...|.::|:
Worm   361 ---GAVSLSAAARVAGRRLDGQQPHQPR 385

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43155	NP_572720.2	Ion_trans_2	<157..214	CDD:285168	30/56 (54%)
		Ion_trans	<240..314	CDD:278921	29/74 (39%)
		Ion_trans_2	<266..319	CDD:285168	23/53 (43%)
twk-4	NP_001343566.1	Ion_trans_2	<178..235	CDD:311712	30/56 (54%)
twk-4	NP_001343566.1	Ion_trans_2	255..329	CDD:311712	28/76 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	79	1.000	Domainoid score	I5635
eggNOG	1	0.900	-	-		E1_KOG1418
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D542195at33208
OrthoFinder	1	1.000	-	-		FOG0000030
OrthoInspector	1	1.000	-	-		oto17474
orthoMCL	1	0.900	-	-		OOG6_110420
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4331
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	10	9.710