DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG43155 and twk-30

DIOPT Version :9

Sequence 1:	NP_572720.2	Gene:	CG43155 / 32092	FlyBaseID:	FBgn0262685	Length:	411	Species:	Drosophila melanogaster
Sequence 2:	NP_492381.3	Gene:	twk-30 / 185335	WormBaseID:	WBGene00006682	Length:	608	Species:	Caenorhabditis elegans

Alignment Length:	383	Identity:	91/383 - (23%)
Similarity:	162/383 - (42%)	Gaps:	106/383 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 HIGLLVSLSIYCGVGGLIFRHLE----------RPAEVER-----LSHLKDIVKTHRERF--LHT 112
            |:.|:.|:.:|..:|.::|:.||          ..|::|:     :..|..:.|..|:::  :..
Worm     8 HVLLIGSVVLYIILGAIVFQMLEGEHLDALKKDHMAKIEQNAKDYVDKLWSVAKRDRDKYKNVED 72

  Fly   113 ILNNTEVHNLDELLSFELAKYEAAVQQAAEGGLLIVADKDFPEPYERWSILQAVFFSSTVLTTIG 177
            ::.:.:...:|:...:....:.|  .:|...|.    |:|.|    .|....:|||::|:||:||
Worm    73 LIKSVKEDTVDDFNDYVDTVFYA--HRAVRHGY----DEDSP----TWDFANSVFFTTTMLTSIG 127

  Fly   178 YGNIVPVTTGGRVFCICFALIGIPFTLTVIADWGRLFATAVSVFGKHM----------------- 225
            ||.:.|.|.|||:|.:.:.|||||.||..:|:..:..:.  ::|..|.
Worm   128 YGYVAPSTFGGRLFGVIYCLIGIPLTLVTVANVAKFLSE--TIFFLHYELWNKCLEWKRKRKGEV 190

  Fly   226 ---PTKPKF---------------TNFIGKTWFYAILAVGFLGVYLAAGAGLLLLWEDDWTFFDG 272
               |.:|.|               ..|...|.|:      |:.||....|.::..|| .||:.:.
Worm   191 EADPLQPMFGDDENEEEILDRVRLVRFPPLTVFF------FVFVYGCIAAWVVRYWE-TWTYVES 248

  Fly   273 FYFCFITMTTIGFGDLVPKKPNYMLLCTLYILIGLALTSTIIELVRRQYATS------------- 324
            .||.||::.|:||||:.| .|..:.:...::::|:.||:..:::|.|.|...
Worm   249 LYFIFISILTVGFGDIRP-SPGNIWVTLAFVVVGVILTTMCMDVVGRMYLKEIHYLGRKLKSSNP 312

  Fly   325 -----WAKLQELSGPMAETLRRLGETAGTGL-----DYTALQKVLTVSMPKWNSKKNE 372
                 .||.:.....||..|.:|.:    |:     ||..|.:       |.:.:|.|
Worm   313 FYLLREAKARRRRAAMASLLAQLAK----GMIFAHKDYNELAR-------KKSKRKKE 359

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43155	NP_572720.2	Ion_trans_2	<157..214	CDD:285168	25/56 (45%)
		Ion_trans	<240..314	CDD:278921	23/73 (32%)
		Ion_trans_2	<266..319	CDD:285168	17/52 (33%)
twk-30	NP_492381.3	Ion_trans_2	103..166	CDD:285168	28/70 (40%)
		Ion_trans_2	224..298	CDD:285168	25/81 (31%)
		FN3	379..469	CDD:238020
		FN3	475..565	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1418
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D542195at33208
OrthoFinder	1	1.000	-	-		FOG0000030
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_110420
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	6	5.680