DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG43155 and twk-42

DIOPT Version :9

Sequence 1:	NP_572720.2	Gene:	CG43155 / 32092	FlyBaseID:	FBgn0262685	Length:	411	Species:	Drosophila melanogaster
Sequence 2:	NP_507483.1	Gene:	twk-42 / 180163	WormBaseID:	WBGene00006692	Length:	444	Species:	Caenorhabditis elegans

Alignment Length:	312	Identity:	75/312 - (24%)
Similarity:	134/312 - (42%)	Gaps:	78/312 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 LNH---IGLLVSLSIYCGVGGLIFRHLERPAEVERLSHLKDIVKTH---RERFLHTILN----NT 117
            |:|   ||:|:..| :.|.|..:....|....::...::: :::|.   ::.|:..:.|    |.
Worm    15 LHHLVKIGVLIVYS-FLGAGLFVLCEAENEKSLKHEDNMR-VLRTSIAAKQVFVQRLQNMYSGNG 77

  Fly   118 EVHNLDEL-LSFELAKYEAAVQQAAEGGLLIVADKDFPEPYERWSILQAVFFSSTVLTTIGYGNI 181
            ......|. |...|::|:||:      |:.|.:     :...||.|...::::.|:.||||||::
Worm    78 SSSEFSETKLRRVLSEYDAAM------GISIDS-----KMKTRWDIWGGLYYAGTIYTTIGYGDL 131

  Fly   182 VPVTTGGRVFCICFALIGIPFTLTVIADWGRLFATAVSVFGKHMPTKPKFTNFIGKTWFYAI--- 243
            ...|..||:..:.:|:||||..:.::.|||.:....|..|.::          ||:.|..::
Worm   132 AAETIWGRICTMLYAMIGIPIVINILNDWGNMLFYFVDHFWQN----------IGRQWIQSLRQK 186

  Fly   244 --------LAVGFLG----------------------VYLAAGAGLLLLWE----------DDWT 268
                    |..|.:.                      :.|.....:|..|.          ::||
Worm   187 LRRRKVQSLEEGSIDKTPLMETSSTPPSPQNPNGTRPIPLLLVLIVLFFWMIQCVAYFAYFENWT 251

  Fly   269 FFDGFYFCFITMTTIGFGDLVPKKPNYMLLCTLYILIGLALTSTIIELVRRQ 320
            .|:..||.||:||||||||..|.. ...:...::||.||::.|..|.:::.|
Worm   252 LFESVYFFFISMTTIGFGDFTPSH-TVAVGGIVFILGGLSVVSMCINVIQMQ 302

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43155	NP_572720.2	Ion_trans_2	<157..214	CDD:285168	21/56 (38%)
		Ion_trans	<240..314	CDD:278921	26/116 (22%)
		Ion_trans_2	<266..319	CDD:285168	22/52 (42%)
twk-42	NP_507483.1	Ion_trans_2	<109..165	CDD:285168	21/55 (38%)
twk-42	NP_507483.1	Ion_trans_2	236..304	CDD:285168	24/68 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1418
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000030
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810