DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG43155 and twk-33

DIOPT Version :9

Sequence 1:	NP_572720.2	Gene:	CG43155 / 32092	FlyBaseID:	FBgn0262685	Length:	411	Species:	Drosophila melanogaster
Sequence 2:	NP_001309463.1	Gene:	twk-33 / 180161	WormBaseID:	WBGene00006685	Length:	617	Species:	Caenorhabditis elegans

Alignment Length:	305	Identity:	73/305 - (23%)
Similarity:	129/305 - (42%)	Gaps:	69/305 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 QSMKW------KSALNHIGLLVSLSIYCGVGGLIF-----RHLERPAEVERLSHLKDIVKTHRER 108
            :||.|      :....|..:::.:.:|..:|.::|     || |:...::.:::|:.::....|.
Worm   200 KSMYWFAFHRKQIGFRHFSVVILVLLYTLLGAVMFWTVESRH-EKAKTLDHVNNLEHLLDRLAEN 263

  Fly   109 FLHTILNNTEVHNLDELLS-------FELAKYEAAVQQAAEGGLLIVADKDFPEPYERWSILQAV 166
            ...:: ||......:|.:.       .||.|.|.  |........:.||.::     :|:...|.
Worm   264 ITESV-NNINTTTTEEEMKVYIREAYIELMKLEG--QYKGSTYYKLEADDNW-----KWTFESAF 320

  Fly   167 FFSSTVLTTIGYGNIVPVTTGGRVFCICFALIGIPFTLTVIADWG--------RLFATAVSVF-- 221
            |||..|.||.|||:|.|.:|.|:|....:..|.:|.||.|:.|.|        :|:|..:..|
Worm   321 FFSMNVYTTTGYGSIAPESTLGQVLVCVYGFIFVPVTLVVLRDLGQFFLVHLTKLYAHGIQKFRE 385

  Fly   222 ---GKH--------MPTKP---KFTNFIGK----TWFYAILAVGFLGVYLAAGAGLLLLWEDDWT 268
               .||        :|.|.   ...:::|.    .:||..|:    |.....|..:.|.
Worm   386 LNGNKHVDEDEIISLPIKACLLLLASYLGACTIFIYFYDELS----GPEPGTGMDMFLC------ 440

  Fly   269 FFDGFYFCFITMTTIGFGDLVPKKPNYMLLCTLYILIGLALTSTI 313
                |||.||:::|||.||::|....:..:.::....|:|:|..:
Worm   441 ----FYFSFISLSTIGLGDIMPNNATFAPIISIIFFFGMAVTKVV 481

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43155	NP_572720.2	Ion_trans_2	<157..214	CDD:285168	23/64 (36%)
		Ion_trans	<240..314	CDD:278921	20/74 (27%)
		Ion_trans_2	<266..319	CDD:285168	14/48 (29%)
twk-33	NP_001309463.1	Hid1	<9..141	CDD:301632
		Ion_trans_2	300..368	CDD:285168	25/72 (35%)
		Ion_trans	<404..498	CDD:278921	21/92 (23%)
		Ion_trans_2	407..491	CDD:285168	21/89 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160163757
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1418
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11003
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.840