DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG43155 and Kcnk2

DIOPT Version :9

Sequence 1:	NP_572720.2	Gene:	CG43155 / 32092	FlyBaseID:	FBgn0262685	Length:	411	Species:	Drosophila melanogaster
Sequence 2:	NP_742039.1	Gene:	Kcnk2 / 170899	RGDID:	621448	Length:	426	Species:	Rattus norvegicus

Alignment Length:	408	Identity:	108/408 - (26%)
Similarity:	173/408 - (42%)	Gaps:	106/408 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 AKGTAGGRR--STACWQSMKWKSALNHIGLLVSLSIYCGVGGLIFRHLERPAEVERLSHLKDIVK 103
            ||.|....|  |.:....||||: ::.|.|:|.|  |..:|..:|:.||:|.|:.:    :..:.
  Rat    39 AKPTVLASRVESDSAINVMKWKT-VSTIFLVVVL--YLIIGATVFKALEQPQEISQ----RTTIV 96

  Fly   104 THRERFL--HTILNNTEVHNLDELLSFELAKYEAAVQQAAEGGLLIVADKDFPEPYERWSILQAV 166
            ..::.|:  |..:|:||   ||||:.        .:..|...|::.:.:..  .....|.:..:.
  Rat    97 IQKQNFIAQHACVNSTE---LDELIQ--------QIVTAINAGIIPLGNNS--NQVSHWDLGSSF 148

  Fly   167 FFSSTVLTTIGYGNIVPVTTGGRVFCICFALIGIPFTLTVIADWGRLFATAVSVFGKHM------ 225
            ||:.||:||||:|||.|.|.||::|||.:||:|||....::|..|....|   :|||.:
  Rat   149 FFAGTVITTIGFGNISPRTEGGKIFCIIYALLGIPLFGFLLAGVGDQLGT---IFGKGIAKVEDT 210

  Fly   226 -------PTKPKFTNFI-----GKTWFYAILAVGFLGVYLAAGAGLLLLWEDDWTFFDGFYFCFI 278
                   .||.:..:.|     |...|.|:.||.|..:             :.|:..|..||..|
  Rat   211 FIKWNVSQTKIRIISTIIFILFGCVLFVALPAVIFKHI-------------EGWSALDAIYFVVI 262

  Fly   279 TMTTIGFGDLVPKKPN------YMLLCTLYILIGLALTSTIIELVR-----------------RQ 320
            |:|||||||.|....:      |..:...:||:|||..:.::.::.                 |.
  Rat   263 TLTTIGFGDYVAGGSDIEYLDFYKPVVWFWILVGLAYFAAVLSMIGDWLRVISKKTKEEVGEFRA 327

  Fly   321 YATSWAKLQELSGPMAETLRRL-------------------GETAGT-GLDYTALQKVLTVSMPK 365
            :|..|.  ..::....||.|||                   .|.||. ..:.|..::.|:|:
  Rat   328 HAAEWT--ANVTAEFKETRRRLSVEIYDKFQRATSVKRKLSAELAGNHNQELTPCRRTLSVN--- 387

  Fly   366 WNSKKNEHSPDIAALEAI 383
            ..:.:.|..|.:...|:|
  Rat   388 HLTSEREVLPPLLKAESI 405

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43155	NP_572720.2	Ion_trans_2	<157..214	CDD:285168	26/56 (46%)
		Ion_trans	<240..314	CDD:278921	25/79 (32%)
		Ion_trans_2	<266..319	CDD:285168	20/75 (27%)
Kcnk2	NP_742039.1	Ion_trans_2	<139..196	CDD:285168	26/56 (46%)
		Ion_trans_2	234..312	CDD:285168	25/90 (28%)
		Required for basal channel activity. /evidence=ECO:0000250\|UniProtKB:P97438	354..426		10/55 (18%)
		Essential for chloroform and halothane sensitivity. /evidence=ECO:0000250\|UniProtKB:P97438	378..426		7/31 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1418
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000030
OrthoInspector	1	1.000	-	-		otm44944
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11003
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.910