Protein Alignment CG43155 and Kcnk2

DIOPT Version :10

• Sequence 1: NP_572720.2
• Gene: CG43155 / 32092
• FlyBaseID: FBgn0262685
• Length: 411
• Species: Drosophila melanogaster
• Sequence 2: NP_001153322.1
• Gene: Kcnk2 / 16526
• MGIID: 109366
• Length: 426
• Species: Mus musculus
• Alignment Length: 390
• Identity: 103/390 - (26%)
• Similarity: 167/390 - (42%)
• Gaps: 104/390 - (26%)

  Fly    57 MKWKSALNHIGLLVSLSIYCGVGGLIFRHLERPAEVERLSHLKDIVKTHRERFL--HTILNNTEV 119
            ||||: ::.|.|:|.|  |..:|..:|:.||:|.|:.:    :..:...::.|:  |..:|:||
Mouse    57 MKWKT-VSTIFLVVVL--YLIIGATVFKALEQPQEISQ----RTTIVIQKQTFIAQHACVNSTE- 113

  Fly   120 HNLDELLSFELAKYEAAVQQAAEGGLLIVADKDFPEPYERWSILQAVFFSSTVLTTIGYGNIVPV 184
              ||||:.        .:..|...|::.:.:..  .....|.:..:.||:.||:||||:|||.|.
Mouse   114 --LDELIQ--------QIVAAINAGIIPLGNSS--NQVSHWDLGSSFFFAGTVITTIGFGNISPR 166

  Fly   185 TTGGRVFCICFALIGIPFTLTVIADWGRLFATAVSVFGKHM-------------PTKPKFTNFI- 235
            |.||::|||.:||:|||....::|..|....|   :|||.:             .||.:..:.|
Mouse   167 TEGGKIFCIIYALLGIPLFGFLLAGVGDQLGT---IFGKGIAKVEDTFIKWNVSQTKIRIISTII 228

  Fly   236 ----GKTWFYAILAVGFLGVYLAAGAGLLLLWEDDWTFFDGFYFCFITMTTIGFGDLVPKKPN-- 294
                |...|.|:.||.|..:             :.|:..|..||..||:|||||||.|....:
Mouse   229 FILFGCVLFVALPAVIFKHI-------------EGWSALDAIYFVVITLTTIGFGDYVAGGSDIE 280

  Fly   295 ----YMLLCTLYILIGLALTSTIIELVR-----------------RQYATSWAKLQELSGPMAET 338
                |..:...:||:|||..:.::.::.                 |.:|..|.  ..::....||
Mouse   281 YLDFYKPVVWFWILVGLAYFAAVLSMIGDWLRVISKKTKEEVGEFRAHAAEWT--ANVTAEFKET 343

  Fly   339 LRRL-------------------GETAGT-GLDYTALQKVLTVSMPKWNSKKNEHSPDIAALEAI 383
            .|||                   .|.||. ..:.|..::.|:|:   ..:.:.|..|.:...|:|
Mouse   344 RRRLSVEIYDKFQRATSVKRKLSAELAGNHNQELTPCRRTLSVN---HLTSEREVLPPLLKAESI 405

  Fly   384  383
            Mouse   406  405

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43155	NP_572720.2	Ion_trans_2	143..214	CDD:462301	27/70 (39%)
		Ion_trans_2	<267..319	CDD:462301	20/74 (27%)
Kcnk2	NP_001153322.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..36
		Important for GNG4 binding and L-glutamate release in astrocytes. /evidence=ECO:0000250|UniProtKB:Q920B6	17..38
		Important for GNG4 binding and L-glutamate release in astrocytes. /evidence=ECO:0000250|UniProtKB:Q920B6	51..61		3/3 (100%)
		Ion_trans_2	<138..196	CDD:462301	26/57 (46%)
		Selectivity filter 1. /evidence=ECO:0000250|UniProtKB:Q920B6	157..162		3/4 (75%)
		Ion_trans_2	234..312	CDD:462301	25/90 (28%)
		Selectivity filter 2. /evidence=ECO:0000250|UniProtKB:Q920B6	266..271		4/4 (100%)
		Interaction with AKAP5. /evidence=ECO:0000305|PubMed:17110924	298..311		1/12 (8%)
		Interaction with AKAP5. /evidence=ECO:0000305|PubMed:17110924	313..326		0/12 (0%)
		Essential for chloroform and halothane sensitivity. /evidence=ECO:0000269|PubMed:10321245	337..385		9/47 (19%)