DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG43155 and Kcnk1

DIOPT Version :9

Sequence 1:	NP_572720.2	Gene:	CG43155 / 32092	FlyBaseID:	FBgn0262685	Length:	411	Species:	Drosophila melanogaster
Sequence 2:	NP_032456.2	Gene:	Kcnk1 / 16525	MGIID:	109322	Length:	336	Species:	Mus musculus

Alignment Length:	290	Identity:	89/290 - (30%)
Similarity:	139/290 - (47%)	Gaps:	68/290 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 LLVSLSIYCGVGGLIFRHLERPAEVERLSHLKDIVKTHRERFL--HTILNNTEVHNLDELLS--F 128
            |::...:|...|.::|..:|.|.|    ..|:..::..:.|||  |..|:..:   |::.|.  .
Mouse    26 LVLGYLLYLVFGAVVFSSVELPYE----DLLRQELRKLKRRFLEEHECLSEPQ---LEQFLGRVL 83

  Fly   129 ELAKYEAAVQQAAEGGLLIVADKDFPEPYERWSILQAVFFSSTVLTTIGYGNIVPVTTGGRVFCI 193
            |.:.|..:|...|.|..             .|....|:||:||||:|.|||:.||::.||:.|||
Mouse    84 EASNYGVSVLSNASGNW-------------NWDFTSALFFASTVLSTTGYGHTVPLSDGGKAFCI 135

  Fly   194 CFALIGIPFTLTVIADWGRLFATA----VSVFGKHMPTKPKFTNFIGKTW---------FYAILA 245
            .:::|||||||        ||.||    |:|   |:..:|..  :....|         .:|:|
Mouse   136 IYSVIGIPFTL--------LFLTAVVQRVTV---HVTRRPVL--YFHIRWGFSKQVVAIVHAVL- 186

  Fly   246 VGFLGV--YLAAGAGLLLLWEDDWTFFDGFYFCFITMTTIGFGDLVPK-------KPNYMLLCTL 301
            :||:.|  :....|.:..:.||||.|.:.||||||:::|||.||.||.       :..|.:..|.
Mouse   187 LGFVTVSCFFFIPAAVFSVLEDDWNFLESFYFCFISLSTIGLGDYVPGEGYNQKFRELYKIGITC 251

  Fly   302 YILIGLALTSTIIELVRRQYATSWAKLQEL 331
            |:|:||.....::|        ::.:|.||
Mouse   252 YLLLGLIAMLVVLE--------TFCELHEL 273

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG43155	NP_572720.2	Ion_trans_2	<157..214	CDD:285168	26/56 (46%)
		Ion_trans	<240..314	CDD:278921	30/82 (37%)
		Ion_trans_2	<266..319	CDD:285168	23/59 (39%)
Kcnk1	NP_032456.2	Ion_trans_2	<100..157	CDD:285168	30/77 (39%)
		Selectivity filter 1. /evidence=ECO:0000250\|UniProtKB:O00180	117..122		3/4 (75%)
		Ion_trans_2	191..267	CDD:285168	27/83 (33%)
		Selectivity filter 2. /evidence=ECO:0000250\|UniProtKB:O00180	225..230		3/4 (75%)
		Important for intracellular retention in recycling endosomes. /evidence=ECO:0000250\|UniProtKB:O00180	293..299
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	310..336
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1418
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000030
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4331
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.840