Protein Alignment CG43155 and Kcna6

DIOPT Version :10

• Sequence 1: NP_572720.2
• Gene: CG43155 / 32092
• FlyBaseID: FBgn0262685
• Length: 411
• Species: Drosophila melanogaster
• Sequence 2: NP_038596.1
• Gene: Kcna6 / 16494
• MGIID: 96663
• Length: 529
• Species: Mus musculus
• Alignment Length: 228
• Identity: 51/228 - (22%)
• Similarity: 81/228 - (35%)
• Gaps: 77/228 - (33%)

  Fly    38 GGLAKG------TAGGR-----------------------RSTAC-WQSMKWKSALNHIGLLVSL 72
            |||..|      |.||.                       |.:|| .::..:::.:|.|.|:...
Mouse   241 GGLGTGGTSSLSTLGGSFFTDPFFLVETLCIVWFTFELLVRFSACPSKAAFFRNIMNIIDLVAIF 305

  Fly    73 SIYCGVG-GLIFRHLERPA-----------------EVERLSHLKDIVKTHRERFLHTILNNTEV 119
            ..:..:| .|:.||.::..                 .|.||..:..|.|..|......||..|..
Mouse   306 PYFITLGTELVQRHEQQSVSGGSGQNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGKTLQ 370

  Fly   120 HNLDEL-----------LSFELAKYEAAVQQAAEGGLLIVADKDFPEPYERWSILQAVFFSSTVL 173
            .::.||           :.|..|.|.|....         .|..||      ||..|.:::...:
Mouse   371 ASMRELGLLIFFLFIGVILFSSAVYFAEADD---------VDSLFP------SIPDAFWWAVVTM 420

  Fly   174 TTIGYGNIVPVTTGGRVFCICFALIGIPFTLTV 206
            ||:|||::.|:|.||::.....|:.|:   ||:
Mouse   421 TTVGYGDMYPMTVGGKIVGSLCAIAGV---LTI 450

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43155	NP_572720.2	Ion_trans_2	143..214	CDD:462301	19/64 (30%)
		Ion_trans_2	<267..319	CDD:462301
Kcna6	NP_038596.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..35
		BTB_POZ_KCNA6	41..170	CDD:349714
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	203..238
		Ion_trans	259..468	CDD:459842	44/210 (21%)
		S4-S5 linker. /evidence=ECO:0000250|UniProtKB:P63142	360..373		3/12 (25%)
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142	422..427		3/4 (75%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	488..513
		PDZ-binding. /evidence=ECO:0000255	527..529