Protein Alignment CG43155 and Kcna2

DIOPT Version :10

• Sequence 1: NP_572720.2
• Gene: CG43155 / 32092
• FlyBaseID: FBgn0262685
• Length: 411
• Species: Drosophila melanogaster
• Sequence 2: NP_032443.3
• Gene: Kcna2 / 16490
• MGIID: 96659
• Length: 499
• Species: Mus musculus
• Alignment Length: 227
• Identity: 49/227 - (21%)
• Similarity: 84/227 - (37%)
• Gaps: 78/227 - (34%)

  Fly    37 GGGL-----AKGTAGGRRSTA-----------C--WQSMK--------------WKSALNHIGLL 69
            |||:     :..|.|.::||:           |  |.|.:              :.:.:|.|.::
Mouse   197 GGGVTFHTYSNSTIGYQQSTSFTDPFFIVETLCIIWFSFEFLVRFFACPSKAGFFTNIMNIIDIV 261

  Fly    70 VSLSIYCGVGGLIFRHLERPAEVE--------------RLSHLKDIVKTHRERFLHTILNNTEVH 120
            ..:..:..:|..:   .|:|.:.:              ||..:..|.|..|......||..|...
Mouse   262 AIIPYFITLGTEL---AEKPEDAQQGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKA 323

  Fly   121 NLDEL-----------LSFELAKYEAAVQQAAEGGLLIVADKDFPEPYERWSILQAVFFSSTVLT 174
            ::.||           :.|..|.|.|...:         .|..||      ||..|.:::...:|
Mouse   324 SMRELGLLIFFLFIGVILFSSAVYFAEADE---------RDSQFP------SIPDAFWWAVVSMT 373

  Fly   175 TIGYGNIVPVTTGGRVFCICFALIGIPFTLTV 206
            |:|||::||.|.||::.....|:.|:   ||:
Mouse   374 TVGYGDMVPTTIGGKIVGSLCAIAGV---LTI 402

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG43155	NP_572720.2	Ion_trans_2	143..214	CDD:462301	20/64 (31%)
		Ion_trans_2	<267..319	CDD:462301
Kcna2	NP_032443.3	Tetramerization domain. /evidence=ECO:0000250|UniProtKB:P63142	1..125
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..26
		BTB_POZ	33..159	CDD:453885
		Ion_trans	162..420	CDD:459842	49/227 (22%)
		S4-S5 linker. /evidence=ECO:0000250|UniProtKB:P63142	312..325		3/12 (25%)
		Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142	374..379		3/4 (75%)
		PDZ-binding. /evidence=ECO:0000250|UniProtKB:P63142	497..499