DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sk1 and LCB4

DIOPT Version :9

Sequence 1:	NP_572717.1	Gene:	Sk1 / 32089	FlyBaseID:	FBgn0030300	Length:	641	Species:	Drosophila melanogaster
Sequence 2:	NP_014814.1	Gene:	LCB4 / 854342	SGDID:	S000005697	Length:	624	Species:	Saccharomyces cerevisiae

Alignment Length:	640	Identity:	145/640 - (22%)
Similarity:	248/640 - (38%)	Gaps:	154/640 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 EEDDHIN----EQLIRIDDIIGSRY---GRRLKKRARGGLNSCRNPNVPGQ----EADSEPD--- 122
            :|||.:.    ...|..:.|:.::|   |::       |.|:.:..:.|.|    .:.||.|
Yeast    60 DEDDSLELLPLNTTIPFNRILNAKYVNVGQK-------GFNNGKISSNPFQTENLSSSSENDDVE 117

  Fly   123 -----SDNSAYLYIYAYLKKEKPLRRVQTLRILRFRS---SNDYGV--NLQTAEMW--------- 168
                 :|.:......::.||:|...:..|:::....|   |...|:  |.|..|:.
Yeast   118 NHSLSNDKAPVSESQSFPKKDKWDTKTNTVKVSPDDSQDNSPSLGIKDNQQLIELTFAVPKGHDV 182

  Fly   169 ---------HHTIRKHKRGNG---------------SSSPADCGKQLLILLNPKSGSGKGRELFQ 209
                     .|..||.:...|               |...:...:.:|:::||..|.|..:.||.
Yeast   183 IPQKLTLLIDHVSRKSRANTGEENISSGTVEEILEKSYENSKRNRSILVIINPHGGKGTAKNLFL 247

  Fly   210 KQVAPLLTEAEVQYDLQITTHPQYAKEFVRTRRDL-LTRYSGIVVASGDGLFYEVLNGLMERMDW 273
            .:..|:|.|:..:.::..|   :||:..:...:|| :::|..|..|||||:.|||:|||..|.|.
Yeast   248 TKARPILVESGCKIEIAYT---KYARHAIDIAKDLDISKYDTIACASGDGIPYEVINGLYRRPDR 309

  Fly   274 RRACRELPLGIIPCGSGNGLAKSVAHHCNEPYEPKPILHATLTCMAGKSTPMDVVRVELATRDKH 338
            ..|..:|.:..:||||||.::.| .|..|.|      .:|.|..:....|.:|::.....:....
Yeast   310 VDAFNKLAVTQLPCGSGNAMSIS-CHWTNNP------SYAALCLVKSIETRIDLMCCSQPSYMNE 367

  Fly   339 FVMYSFLSVGWGLIADIDIESERLRSIGAQRFTLWAIKRLIGLRSYKGR--VSYLLGKGKKEPPV 401
            :...||||..:|:||:.||.:|.:|.:|..||.|.....:|..:.|...  |.| ..|.|||..|
Yeast   368 WPRLSFLSQTYGVIAESDINTEFIRWMGPVRFNLGVAFNIIQGKKYPCEVFVKY-AAKSKKELKV 431

  Fly   402 EAARE-------LPAESTAAGIRSSLPLNAGEFHDLPEEEEGEAVLDGEQFADAISLDRSVYRQH 459
            .....       |..|...:...|...|:....::..::|.....|:.:.|.....:...|.|
Yeast   432 HFLENKDKNKGCLTFEPNPSPNSSPDLLSKNNINNSTKDELSPNFLNEDNFKLKYPMTEPVPR-- 494

  Fly   460 ADSWHSAMSRRTAYYSLGGPSMRSNRSRMSISQRIEAANAEFAERVP---TGTIPPLQMPLLSSD 521
              .|                               |..::|..:.:.   ||.:|
Yeast   495 --DW-------------------------------EKMDSELTDNLTIFYTGKMP---------- 516

  Fly   522 GWICEDGDFVMVHAAYTTHLSSDVFFAPESRLDDGLIYLVIIRRGVSRHQLLNFMLNLNAGTHLP 586
                              :::.|..|.|.:...||.|.|||....:...::...:|:|:.|:|:.
Yeast   517 ------------------YIAKDTKFFPAALPADGTIDLVITDARIPVTRMTPILLSLDKGSHVL 563

  Fly   587 IGEDPFIKVVPCRAFRIEPSSSDGILVVDGERVEYGPIQAEVMPGLINVMTTSGQ 641
            ..|....|::   |::|.|....|:..||||:....|:|.|:||.|...:..:|:
Yeast   564 EPEVIHSKIL---AYKIIPKVESGLFSVDGEKFPLEPLQVEIMPMLCKTLLRNGR 615

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sk1	NP_572717.1	PLN02958	<189..622	CDD:215517	108/445 (24%)
Sk1	NP_572717.1	DAGK_cat	191..330	CDD:279163	46/139 (33%)
LCB4	NP_014814.1	LCB5	225..540	CDD:224513	93/388 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343286
Domainoid	1	1.000	90	1.000	Domainoid score	I1770
eggNOG	1	0.900	-	-		E1_COG1597
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	155	1.000	Inparanoid score	I1088
Isobase	1	0.950	-	0	Normalized mean entropy	S4295
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001465
OrthoInspector	1	1.000	-	-		mtm9231
orthoMCL	1	0.900	-	-		OOG6_101566
Panther	1	1.100	-	-	O	PTHR12358
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R653
SonicParanoid	1	1.000	-	-		X918
TreeFam	1	0.960	-	-
	14	13.730