DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sk1 and SPHK2

DIOPT Version :9

Sequence 1:	NP_572717.1	Gene:	Sk1 / 32089	FlyBaseID:	FBgn0030300	Length:	641	Species:	Drosophila melanogaster
Sequence 2:	XP_016882497.1	Gene:	SPHK2 / 56848	HGNCID:	18859	Length:	716	Species:	Homo sapiens

Alignment Length:	599	Identity:	200/599 - (33%)
Similarity:	294/599 - (49%)	Gaps:	100/599 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    99 RARGGLNSCRNPNVPGQEAD------SEPDSDNSAYLYIYAYLKKEKPLRRVQTLRILRFRSSND 157
            |.||||       ||..|..      |...||::||..||.|.:..:..||..| |..|...:..
Human   148 RPRGGL-------VPLAEVSGCCTLRSRSPSDSAAYFCIYTYPRGRRGARRRAT-RTFRADGAAT 204

  Fly   158 YGVNLQTAEMWHHTIRKHKR-----GNGSSSPADCGK--QLLILLNPKSGSGKGRELFQKQVAPL 215
            |..|...|:.|...:....|     |:|..:|....:  :||:|:||..|.|...:..:..|.|:
Human   205 YEENRAEAQRWATALTCLLRGLPLPGDGEITPDLLPRPPRLLLLVNPFGGRGLAWQWCKNHVLPM 269

  Fly   216 LTEAEVQYDLQITTHPQYAKEFVRTRRDLLTRYSGIVVASGDGLFYEVLNGLMERMDWRRACREL 280
            ::||.:.::|..|....:|:|.|:...  |:.:.|||..|||||.:||||||::|.||..|.: :
Human   270 ISEAGLSFNLIQTERQNHARELVQGLS--LSEWDGIVTVSGDGLLHEVLNGLLDRPDWEEAVK-M 331

  Fly   281 PLGIIPCGSGNGLAKSVAHHCNEPYEP----KPILHATLTCMAGKSTPMDVVRVELATRDKHFVM 341
            |:||:||||||.||.:|..|..  :||    ..:|:.:|....|...|:|::.|.||:..:.|
Human   332 PVGILPCGSGNALAGAVNQHGG--FEPALGLDLLLNCSLLLCRGGGHPLDLLSVTLASGSRCF-- 392

  Fly   342 YSFLSVGWGLIADIDIESERLRSIGAQRFTLWAIKRLIGLRSYKGRVSYL--------------L 392
             |||||.||.::|:||:|||.|::|:.||||..:..|..|.:|:||:|||              |
Human   393 -SFLSVAWGFVSDVDIQSERFRALGSARFTLGTVLGLATLHTYRGRLSYLPATVEPASPTPAHSL 456

  Fly   393 GKGKKE--------PPV----------EAARELPAESTAA-GIRSSLP---LNAGEFHDLPE--- 432
            .:.|.|        ||:          :....||..:.|: |....||   ||.|.    ||
Human   457 PRAKSELTLTPDPAPPMAHSPLHRSVSDLPLPLPQPALASPGSPEPLPILSLNGGG----PELAG 517

  Fly   433 --EEEGEAVLDGEQFADAISLDRSVYRQHADSWHSAMSRRTAYYSLGGPSM--RSNRSRMSISQR 493
              ...|:|.|..:      .|..|.......:.||.:|.       |.|.:  .|.....:...|
Human   518 DWGGAGDAPLSPD------PLLSSPPGSPKAALHSPVSE-------GAPVIPPSSGLPLPTPDAR 569

  Fly   494 IEAANAEFAERVPTGTIPPLQMPLLSSDGWICEDGDFVMVHAAYTTHLSSDVFFAPESRLDDGLI 558
            :.|:..    ..|...:|||..||  ...|:..:||||::.|...:||.:|:..||.:|.||||:
Human   570 VGASTC----GPPDHLLPPLGTPL--PPDWVTLEGDFVLMLAISPSHLGADLVAAPHARFDDGLV 628

  Fly   559 YLVIIRRGVSRHQLLNFMLNLNAGTHLPIGEDPFIKVVPCRAFRIEPSSSDGILVVDGERVEYGP 623
            :|..:|.|:||..||...|.:..|:|..:| .|.:.....||||:||.:..|:|.||||:|||||
Human   629 HLCWVRSGISRAALLRLFLAMERGSHFSLG-CPQLGYAAARAFRLEPLTPRGVLTVDGEQVEYGP 692

  Fly   624 IQAEVMPGLINVMT 637
            :||::.||:..::|
Human   693 LQAQMHPGIGTLLT 706

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sk1	NP_572717.1	PLN02958	<189..622	CDD:215517	163/481 (34%)
Sk1	NP_572717.1	DAGK_cat	191..330	CDD:279163	55/142 (39%)
SPHK2	XP_016882497.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146141
Domainoid	1	1.000	177	1.000	Domainoid score	I3605
eggNOG	1	0.900	-	-		E1_COG1597
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H32456
Inparanoid	1	1.050	282	1.000	Inparanoid score	I2882
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG47523
OrthoDB	1	1.010	-	-		D561206at33208
OrthoFinder	1	1.000	-	-		FOG0001465
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101566
Panther	1	1.100	-	-	O	PTHR12358
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R653
SonicParanoid	1	1.000	-	-		X918
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.800