DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sk1 and Sphk2

DIOPT Version :9

Sequence 1:	NP_572717.1	Gene:	Sk1 / 32089	FlyBaseID:	FBgn0030300	Length:	641	Species:	Drosophila melanogaster
Sequence 2:	NP_001012066.1	Gene:	Sphk2 / 308589	RGDID:	1307757	Length:	616	Species:	Rattus norvegicus

Alignment Length:	662	Identity:	207/662 - (31%)
Similarity:	312/662 - (47%)	Gaps:	109/662 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 VASGTPTELSEIFFVDNSRRKQSIKIQVKLCPEGVYLRR-ETEEDDHINEQLIRIDDIIGSRYGR 94
            ||:.||....|.    .|......:..:.|..:.::::| ..:.:....:.|:.:|::.|.
  Rat     9 VAASTPILHGEF----GSYPAHGPRFALTLTTQALHIQRLRPKPEARPRDGLVPLDEVSGC---- 65

  Fly    95 RLKKRARGGLNSCRNPNVPGQEADSEPDSDNSAYLYIYAYLKKEKPLRRVQTLRILRFRSSNDYG 159
                   |.|.| |:|            .|.:||..||.|.:..:..||..| |..|...:..|.
  Rat    66 -------GTLQS-RSP------------EDTAAYFCIYTYPRGRRGGRRRAT-RTFRADGAATYV 109

  Fly   160 VNLQTAEMWHHTIRKHKRGNGSSSPADCGKQ-------LLILLNPKSGSGKGRELFQKQVAPLLT 217
            .|...|:.|...:....||...|...:...:       ||:|:||..|.|...:.....|.|:::
  Rat   110 ENRAEAQRWATALMCLLRGVPLSGDQEITPELLPRKPRLLLLVNPFGGRGLAWQRCMDHVVPMIS 174

  Fly   218 EAEVQYDLQITTHPQYAKEFVRTRRDLLTRYSGIVVASGDGLFYEVLNGLMERMDWRRACRELPL 282
            ||.:.::|..|....:|:|.|:...  |:.:.|||..|||||.|||||||::|.||..|.| :|:
  Rat   175 EAGLSFNLIQTERQNHARELVQGLS--LSEWEGIVTVSGDGLLYEVLNGLLDRPDWEDAVR-MPI 236

  Fly   283 GIIPCGSGNGLAKSVAHH--CNEPYEPKPILHATLTCMAGKSTPMDVVRVELATRDKHFVMYSFL 345
            |::||||||.||.:|.||  ..:......:|:.:|....|.|.|:|::.|.||:..:.|   |||
  Rat   237 GVLPCGSGNALAGAVNHHGGFEQTVGVDLLLNCSLLLCRGGSHPLDLLSVTLASGSRCF---SFL 298

  Fly   346 SVGWGLIADIDIESERLRSIGAQRFTLWAIKRLIGLRSYKGRVSYL--------------LGKGK 396
            ||.||.::|:||.|||.|::|:.||||.|:..|..|.:|:||:|||              |.:.|
  Rat   299 SVAWGFLSDVDIHSERFRALGSARFTLGAVLGLATLHTYRGRLSYLPATTEPALPIPGHGLPRAK 363

  Fly   397 KE-----PPVEAARELPAESTAAGIRSSLPLNA----GEFHDLPEEE--------------EGEA 438
            .|     .|..||...|...:.:.:...||..|    |....||:..              .|:|
  Rat   364 SELALAPAPAPAATHSPLHRSVSDLPLPLPQPALASPGSPEPLPDLSLNGGGPELTGDWGGAGDA 428

  Fly   439 VLDGEQFADAISLDRSVYRQHADSWHSAMSRRTAYYS--LGGPS-MRSNRSRMSISQRIEAANAE 500
            .|..:....:                |..:.:||..|  ..||| |.::.....|....||:...
  Rat   429 PLSPDPLLPS----------------SPNAFKTAQLSPIAEGPSEMPASGLLPPIHNAPEASTWG 477

  Fly   501 FAERVPTGTIPPLQMPLLSSDGWICEDGDFVMVHAAYTTHLSSDVFFAPESRLDDGLIYLVIIRR 565
            .|:.:    :|||..||  ...|:..:|:||::.|...:||.:|:..||.:|.|||:::|..:|.
  Rat   478 PADHL----LPPLGSPL--PQDWVTIEGEFVLMLAILPSHLCADLMAAPHARFDDGVVHLCWVRS 536

  Fly   566 GVSRHQLLNFMLNLNAGTHLPIGEDPFIKVVPCRAFRIEPSSSDGILVVDGERVEYGPIQAEVMP 630
            |:||..||..:|.:..|.|..:| .|.:.....||||:||.:..|:|.||||.||||||||:|.|
  Rat   537 GISRAALLRILLAMEHGNHFSLG-CPHLGYAAARAFRLEPLTPRGVLTVDGELVEYGPIQAQVHP 600

  Fly   631 GLINVMT-TSGQ 641
            .|..::| .:||
  Rat   601 SLATLLTGPAGQ 612

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sk1	NP_572717.1	PLN02958	<189..622	CDD:215517	161/481 (33%)
Sk1	NP_572717.1	DAGK_cat	191..330	CDD:279163	56/140 (40%)
Sphk2	NP_001012066.1	PLN02958	<152..607	CDD:215517	167/483 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166339909
Domainoid	1	1.000	150	1.000	Domainoid score	I4285
eggNOG	1	0.900	-	-		E1_COG1597
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H32456
Inparanoid	1	1.050	257	1.000	Inparanoid score	I3072
OMA	1	1.010	-	-		QHG47523
OrthoDB	1	1.010	-	-		D561206at33208
OrthoFinder	1	1.000	-	-		FOG0001465
OrthoInspector	1	1.000	-	-		otm45376
orthoMCL	1	0.900	-	-		OOG6_101566
Panther	1	1.100	-	-	O	PTHR12358
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X918
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770