DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sk1 and SPHK2

DIOPT Version :9

Sequence 1:	NP_572717.1	Gene:	Sk1 / 32089	FlyBaseID:	FBgn0030300	Length:	641	Species:	Drosophila melanogaster
Sequence 2:	NP_001190787.1	Gene:	SPHK2 / 10723114	AraportID:	AT4G21534	Length:	481	Species:	Arabidopsis thaliana

Alignment Length:	497	Identity:	132/497 - (26%)
Similarity:	211/497 - (42%)	Gaps:	144/497 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   168 WHHTIRKHKRGNGSSSPADCGKQLLILLNPKSGSGKGRELFQKQVAPLLTEAEVQYDLQITTHPQ 232
            |.:.:|::....|..      |:||:.:||..|....||:|.|:|.||..:|:||.::|.|.:..
plant    99 WCYKLRQYLDSLGRP------KRLLVFVNPFGGKKSAREIFVKEVKPLFEDADVQLEIQETKYQL 157

  Fly   233 YAKEFVRTRRDLLTRYSGIVVASGDGLFYEVLNGLMERMDWRRACRELPLGIIPCGSGNGLAKS- 296
            :|||||::..  :::|.|||..||||:..||:|||:||.|||.|.: ||:|::|.|:|||:.||
plant   158 HAKEFVKSMD--VSKYDGIVCVSGDGILVEVVNGLLERADWRNALK-LPIGMVPAGTGNGMIKSL 219

  Fly   297 ---VAHHC--NEPYEPKPILHATLTCMAGKSTPMDVVRVELATRDKHFVMYSFLSVGWGLIADID 356
               |...|  |.         ||::.:.|....:||..:  |..:..|  :|.|.:.||||||||
plant   220 LDTVGLRCCANS---------ATISIIRGHKRSVDVATI--AQGNTKF--FSVLMLAWGLIADID 271

  Fly   357 IESERLRSIGAQRFTLWAIKRLIGLRSYKGRVSYLLGKGKKEPPVEAARELPAESTAAGIRSSLP 421
            ||||:.|.:|:.|...:|::|:|.||.|.||:.:|...|
plant   272 IESEKFRWMGSARIDFYALQRIICLRRYNGRILFLPAPG-------------------------- 310

  Fly   422 LNAGEFHDLPEEEEGEAVLDGEQFADAISLDRSVYRQHADSWHSAMSRRTAYYSLGGPSMRSNRS 486
                                                               :...|.|      :
plant   311 ---------------------------------------------------FEGYGQP------A 318

  Fly   487 RMSISQRIEAANAEFAERVPTGTIPPLQMPLLSSDGWICEDGDFVMVHAAYTTHLSSDVFFAPES 551
            ..|:.|....::.|...:.|......|:        |....|.||.:........|.:...||.:
plant   319 SCSLYQEPHVSDKEVGYQGPETKFEDLE--------WREMKGPFVTIWLHNVPWGSENTLTAPAA 375

  Fly   552 RLDDGLIYLVIIRRGVSRHQLLNFMLNLNAGTHLPIGEDPFIKVVPCRAFRIEPSS--------- 607
            :..||.:.|::: :...:..||:.|...::|||:   |.|:|..:..:||.:||.:
plant   376 KFSDGYLDLIVL-KNCPKLVLLSLMRQTSSGTHV---ESPYIVYIKVKAFVLEPGALVDEPDKEG 436

  Fly   608 ---SDGILVVDGER---------VEYGPIQAEVMPGLINVMT 637
               |||.::..|:|         :.|..:|..|..||..:.:
plant   437 IIDSDGEVLARGKRTYKCDQKALMSYDKLQVTVDQGLATLFS 478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sk1	NP_572717.1	PLN02958	<189..622	CDD:215517	124/459 (27%)
Sk1	NP_572717.1	DAGK_cat	191..330	CDD:279163	59/144 (41%)
SPHK2	NP_001190787.1	PLN02958	1..480	CDD:215517	132/497 (27%)
SPHK2	NP_001190787.1	DAGK_cat	115..249	CDD:279163	59/145 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	108	1.000	Domainoid score	I2150
eggNOG	1	0.900	-	-		E1_COG1597
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	200	1.000	Inparanoid score	I1316
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D681139at2759
OrthoFinder	1	1.000	-	-		FOG0001465
OrthoInspector	1	1.000	-	-		mtm1039
orthoMCL	1	0.900	-	-		OOG6_101566
Panther	1	1.100	-	-	LDO	PTHR12358
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X918
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.830