DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sk1 and sphk1

DIOPT Version :9

Sequence 1:	NP_572717.1	Gene:	Sk1 / 32089	FlyBaseID:	FBgn0030300	Length:	641	Species:	Drosophila melanogaster
Sequence 2:	XP_002667585.3	Gene:	sphk1 / 100331840	-ID:	-	Length:	493	Species:	Danio rerio

Alignment Length:	585	Identity:	175/585 - (29%)
Similarity:	269/585 - (45%)	Gaps:	166/585 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 ETEEDDHINEQLIRIDDIIGSRYGRRLKKRARGGLNSCRNPNVPGQEADSEPDSDNSAYLYIYAY 134
            :|...:|::     :.|.:|||..|                   |:..|.:     :.||.:|.|
Zfish    40 QTPAPEHLD-----LRDCLGSRAHR-------------------GEREDRD-----AYYLCVYFY 75

  Fly   135 LKKEK-----PLRRVQTLR---ILRFRSSND---------YGVNLQTAEMWHHTIRKHKRGNG-- 180
            ..:.:     |:|:....|   :|....:||         ....|:.||.|...|| ::.||.
Zfish    76 PYRRRWMAWGPVRQRDERRFRLVLNSDDNNDDEQEEEDEEEDAKLREAERWARAIR-NRPGNTRG 139

  Fly   181 ---SSSPADCGKQLLILLNPKSGSGKGRELFQKQVAPLLTEAEVQYDLQITTHPQYAKEFVRTRR 242
               |.....||  :::|:||:||.|:....:...|..:||||::.:.|.||....:|::.||:..
Zfish   140 VLFSEVRRACG--VMVLVNPQSGRGQAMAQYNGHVQRMLTEADIPHTLVITERQNHARDLVRSTD 202

  Fly   243 DLLTRYSGIVVASGDGLFYEVLNGLMERMDWRRACRELPLGIIPCGSGNGLAKSVAHHCN-EPYE 306
              |:::..:::.|||||.:||:||||||.||.:|. :.||||:|.||||.||.||.|:.. .|..
Zfish   203 --LSQWDALIILSGDGLLFEVVNGLMERPDWEKAI-QTPLGILPGGSGNALAASVHHYTRASPVW 264

  Fly   307 PKPILHAT--LTCMAGKSTPMDVVRVELATRDKHFVMYSFLSVGWGLIADIDIESERLRSIGAQR 369
            .:.:|.:.  |.| .|..:.:|::.|:|::..:   ::||||:.||.:||:|||||..|.|||.|
Zfish   265 GEDLLTSCGFLLC-KGLVSGLDLISVQLSSGAR---LFSFLSLAWGFVADVDIESETFRQIGALR 325

  Fly   370 FTLWAIKRLIGLRSYKGRVSYLLGKGKKEPPVEAARELPAESTAAGIRSSLPLNAGEFHDLPEEE 434
            |.|..:.||..||.|:|:::|                |||..|.: :.|:
Zfish   326 FILGTLVRLASLRIYQGKLAY----------------LPAGETDS-VSST--------------- 358

  Fly   435 EGEAVLDGEQFADAISLDRSVYRQHADSWHSAMSRRTAYYSLGGPSMRSNRSRMSISQRIEAANA 499
             ||.:|:                                                     :...|
Zfish   359 -GENLLN-----------------------------------------------------DHLMA 369

  Fly   500 EFAERVPTGTIPPLQMPLLSSDGW-ICEDGDFVMVHAAYTTHLSSDVFFAPESRLDDGLIYLVII 563
            .|.:.||              ..| :.|:.:||:|.|.:.:|||.|:..||.:|.|||:|:|..:
Zfish   370 PFGQPVP--------------QNWTLVEEREFVLVLAMFQSHLSEDLMAAPGARADDGIIHLFYL 420

  Fly   564 RRGVSRHQLLNFMLNLNAGTHLPIGEDPFIKVVPCRAFRIEPSSSDGILVVDGERVEYGPIQAEV 628
            ..||||..||.....:.:||||..| ...:..|..:|.|:||.|:||:|.||||||.|||:||:|
Zfish   421 TAGVSRATLLRLFRAMQSGTHLDCG-CAHLVYVRAQAIRLEPLSADGVLTVDGERVHYGPVQAQV 484

Fly 629 628
Zfish 485 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sk1	NP_572717.1	PLN02958	<189..622	CDD:215517	139/436 (32%)
Sk1	NP_572717.1	DAGK_cat	191..330	CDD:279163	54/141 (38%)
sphk1	XP_002667585.3	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170579706
Domainoid	1	1.000	107	1.000	Domainoid score	I6447
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	290	1.000	Inparanoid score	I2781
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D561206at33208
OrthoFinder	1	1.000	-	-		FOG0001465
OrthoInspector	1	1.000	-	-		mtm6496
orthoMCL	1	0.900	-	-		OOG6_101566
Panther	1	1.100	-	-	LDO	PTHR12358
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X918
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.900