DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sk1 and cerkl

DIOPT Version :9

Sequence 1:	NP_572717.1	Gene:	Sk1 / 32089	FlyBaseID:	FBgn0030300	Length:	641	Species:	Drosophila melanogaster
Sequence 2:	NP_001082943.1	Gene:	cerkl / 100037318	ZFINID:	ZDB-GENE-070410-38	Length:	577	Species:	Danio rerio

Alignment Length:	602	Identity:	136/602 - (22%)
Similarity:	221/602 - (36%)	Gaps:	175/602 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 RRKQSIKIQV---KLCPEGVYLRR-ETE--EDDHINEQLIRIDDIIGSRYGRRLKKRARGGLNSC 107
            ::|||.|..|   :||||..|..| ||:  .|:.|...:.:|:           ||.....|.:.
Zfish    45 KQKQSQKRSVSAPQLCPEEDYKERVETKYRPDEPIVRGIFQIE-----------KKSHDVVLTTT 98

  Fly   108 RNPNVPGQEADSEPDSDNSAYLYIYAYLKKEK---PLRRVQTLRILRFRSS-------------- 155
            |....|.|......|.|          |||::   .|:.|..:::.|.||:
Zfish    99 RVTWTPIQPETPTADRD----------LKKQEEYVDLKDVFAVKVKRRRSAGQQSGGTLLGITLF 153

  Fly   156 ---------NDYGVNLQT-----AEMWHHTIRKHKRGNGSSSPADCGKQLLILLNPKSGSGKGRE 206
                     .|:.::|..     .|:|..|:::...| ..:.|    |.|.:.:||.|...:..:
Zfish   154 QCKKKGLKLKDHAIHLNNLSVDHCEIWFKTLKELLNG-FKNRP----KSLKVFVNPISHKKEAYQ 213

  Fly   207 LFQKQVAPLLTEAEVQYDLQITTHPQYAKEFVRTRRDLLTRYSGIVVASGDGLFYEVLNGLMER- 270
            ::..:||||...|::|.|:.||....:|...::...  |..|.|:|...|||...||.:||:.|
Zfish   214 IYLDEVAPLFKLADIQVDVTITERKGHALSILKDCS--LEDYDGVVCVGGDGSVSEVAHGLLLRA 276

  Fly   271 -MDWRRACRE-----------LPLGIIPCGSGNGLAKSVAHHCNEPYEPKPILHATLTCMAGKST 323
             ||   |.|:           ||||:||.||.:.:|.||       :..:....|.|..:.|...
Zfish   277 QMD---AGRDTDSIFTPVQAALPLGVIPAGSTDVVACSV-------HGIRRAATAALHIIMGHHQ 331

  Fly   324 PMDVVRVELATRDKHFVMYSFLSVGWGLIADIDIESERLRSI-GAQRFTLWAIKRLIGLRSYKGR 387
            |:||.......|...|...:....|...:|    .:||.|.: .:||.....||.|..|:.....
Zfish   332 PVDVCSFSCMGRLLRFGFSAMFGFGGRTLA----LAERHRWMPPSQRREFALIKTLAKLKPEDCE 392

  Fly   388 VSYLLGKGKKEPPVEAARELPAES-----------------------------TAAGIRSSLPLN 423
            :|:|..||.::   :...||..:.                             ...|:..:..||
Zfish   393 LSFLTAKGAED---QKKAELNGDGGDICEGDWQSRKGLFLNISIMAIPCLCSMAPRGLAPNTRLN 454

  Fly   424 AGEFHDLPEEEEGEAVLDGEQFADAISLDRSVYRQHADSWHSAMSRRTAYYSLGGPSMRSNRSRM 488
            .|..                ......:..||.:.:|...::|. :.:..:..:...|:::.|.|.
Zfish   455 NGSM----------------ALISVGNTSRSEFIKHLKRYNST-NNQFGFSFIETHSVKAVRLRP 502

  Fly   489 S--------ISQRIEAANAEFAERVPTGTIPPLQMPLLSSDG---WICEDGD--------FVMVH 534
            |        :|:..|.::::             ..|::||:|   |.. |||        .:.||
Zfish   503 SSQSSWTDDVSEENEESDSK-------------NTPIISSEGTYPWNI-DGDLLDVPSELLIRVH 553

  Fly   535 AAYTTHLSSDVFFAPES 551
            ....|...|||..|.|:
Zfish   554 PQLLTLFGSDVEEAEET 570

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sk1	NP_572717.1	PLN02958	<189..622	CDD:215517	97/425 (23%)
Sk1	NP_572717.1	DAGK_cat	191..330	CDD:279163	47/151 (31%)
cerkl	NP_001082943.1	PLN02204	92..565	CDD:215126	115/537 (21%)
cerkl	NP_001082943.1	LCB5	196..561	CDD:224513	92/414 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170579700
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1597
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D681139at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.750