DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Evi5 and TBC1D4

DIOPT Version :9

Sequence 1:	NP_727526.2	Gene:	Evi5 / 32088	FlyBaseID:	FBgn0262740	Length:	807	Species:	Drosophila melanogaster
Sequence 2:	NP_055647.2	Gene:	TBC1D4 / 9882	HGNCID:	19165	Length:	1298	Species:	Homo sapiens

Alignment Length:	452	Identity:	130/452 - (28%)
Similarity:	224/452 - (49%)	Gaps:	52/452 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 LLAKLEAANKLIESDAKSLNSLHSTHSRKNSDTSQISLTSSGNSVAEEDIWTTWATILNDWEGAL 102
            ||.::|..|:.:|:            ||....:.::.|........::::..||...|.:....:
Human   852 LLLRMEKENQKLEA------------SRDELQSRKVKLDYEEVGACQKEVLITWDKKLLNCRAKI 904

  Fly   103 KRKNPCVSELVRRGIPHHFRAIVWQ----------QLSGASDGDKKQYAEYIKATSACEKVIRRD 157
            :.....:..|::.|:|...|..:||          :|..........|.|.:|..:|.:..|..|
Human   905 RCDMEDIHTLLKEGVPKSRRGEIWQFLALQYRLRHRLPNKQQPPDISYKELLKQLTAQQHAILVD 969

  Fly   158 IARTYPEVEFFKEKDGPGQEALFNVIKAYSLHDREVGYCQGSGFIVGLLLMQMPEEEAFAVLVQI 222
            :.||:|...:|..:.||||.:|||::|||||.|:|||||||..|:.|:||:.|.||:||.:|..:
Human   970 LGRTFPTHPYFSVQLGPGQLSLFNLLKAYSLLDKEVGYCQGISFVAGVLLLHMSEEQAFEMLKFL 1034

  Fly   223 MQQHRMRHMFKPSMSELGLCMYQLENLVQEQIPDMHIHFQQQGFQTTMYASSWFLTLYTTTLNVN 287
            |.....|..::|.|..|.:.||||..|:.:...|::.|.::.....::||:.|||||:.:..::.
Human  1035 MYDLGFRKQYRPDMMSLQIQMYQLSRLLHDYHRDLYNHLEENEISPSLYAAPWFLTLFASQFSLG 1099

  Fly   288 LSCRIMDVFLSEGMEFIFKVALALLLTGKDTLL--CLDMEAMLKFFQKELPGRVEADVEGFFNLA 350
            ...|:.|:...:|.|.||||||: ||:.::||:  |...|.:::|.:..||....:::|......
Human  1100 FVARVFDIIFLQGTEVIFKVALS-LLSSQETLIMECESFENIVEFLKNTLPDMNTSEMEKIITQV 1163

  Fly   351 YSIKLNTKRMKKMEKEYQDLKKKEQ------EEMAELRRLRRENCLLKQRN-ELLE--------- 399
            :.:.: :|::...|.||..|:.:.|      |:...|.:|.|.|..||::| :|||
Human  1164 FEMDI-SKQLHAYEVEYHVLQDELQESSYSCEDSETLEKLERANSQLKRQNMDLLEKLQVAHTKI 1227

  Fly   400 -AESAELADRLVR-----GQVSRAEEEETSYAIQTELMQLRRSYLEVSHQLENANEEVRGLS 455
             |..:.|.:.|.|     ..:...|:|:.:|  |..:.|||:  |..:..|.|.:..:|.|:
Human  1228 QALESNLENLLTRETKMKSLIRTLEQEKMAY--QKTVEQLRK--LLPADALVNCDLLLRDLN 1285

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Evi5	NP_727526.2	TBC	113..320	CDD:214540	78/216 (36%)
Evi5	NP_727526.2	DUF4527	627..>731	CDD:291689
TBC1D4	NP_055647.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..31
		PTB	31..190	CDD:214675
		PTB_TBC1D1_like	193..437	CDD:269967
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	241..287
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	317..353
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	586..685
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	725..765
		DUF3350	806..864	CDD:288663	4/11 (36%)
		TBC	918..1132	CDD:214540	79/214 (37%)
		CENP-Q	1199..>1270	CDD:289839	22/74 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4436
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R541
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840