DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Evi5 and GYP5

DIOPT Version :9

Sequence 1:	NP_727526.2	Gene:	Evi5 / 32088	FlyBaseID:	FBgn0262740	Length:	807	Species:	Drosophila melanogaster
Sequence 2:	NP_015075.1	Gene:	GYP5 / 855827	SGDID:	S000006170	Length:	894	Species:	Saccharomyces cerevisiae

Alignment Length:	542	Identity:	136/542 - (25%)
Similarity:	248/542 - (45%)	Gaps:	88/542 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 TSEMDLLAK--LEAANKLIESDAKSLNSLHSTHS-RKNSDTSQISLTSSGN---SVAEED----- 86
            |:|::|:|.  .:.::.|.:...::..||....| .|::.||.:...|..|   :|.|||
Yeast   356 TAEINLIASRYRKTSHHLNKEGEETRESLQEGQSFLKSTFTSFLENLSEYNEVENVNEEDREMFK 420

  Fly    87 -IWTTWATILNDWEGALKRKNPCVSELVRRGIPHHFRAIVWQQLSGASDGDKKQYAEYIKATSAC 150
             .|:.|..::||:......:...:...|..|||...|.|:||.::.:...:.:...|.:..|...
Yeast   421 IDWSFWTQVVNDYATVASNEPENLEAHVTNGIPPQIRGIIWQLMANSKSREMEDIYETLLDTECL 485

  Fly   151 -EKVIRRDIARTYPEVEFFKEKDGPGQEALFNVIKAYSLHDREVGYCQGSGFIVGLLLMQMPEE- 213
             |..||||:.||    :|..|..   .|:|:.|||.||::|.:|||.||.|||...||:....|
Yeast   486 HEATIRRDLRRT----KFVAEDK---MESLYKVIKVYSVYDPDVGYTQGMGFIAAPLLINCENEA 543

  Fly   214 EAFAVLVQIMQQHRMRHMFKPSMSELGLCMYQLENLVQEQIPDMHIHFQQQGFQTTMYASSWFLT 278
            |:|.:||.:|:.:.:|.:|.|.|..|.|.:||.:.|::|..|.::....::|..:||||:.||||
Yeast   544 ESFGLLVGLMKNYGLRELFLPGMPGLMLMLYQFDRLLEEHSPSLYNRLIREGISSTMYATQWFLT 608

  Fly   279 LYTTTLNVNLSCRIMDVFLSEGMEFIFKVALALLLTGKDTLLCLDMEAMLKFFQKEL-------- 335
            .:.....:....||.|:...||:|.:.|.|:.|:|..::||:.|..:.:|.|.:.||
Yeast   609 FFAYKFPLEFVLRIFDIVFVEGIEVLLKFAVNLMLKNEETLVKLRFDELLDFLKDELFNYYLMGN 673

  Fly   336 ---------------------PGRVEADVEGFFNLAYS-IKLNTKRMKKMEKEYQDLKKKEQEEM 378
                                 .|....:|:.|.:.|.: :.:....:::...||.::.:|||::.
Yeast   674 QDDASVVQMGLSNGNSFKGNDDGTFSYNVDLFVHDAMTGVYITPLTLRRYRGEYVEIHEKEQKKE 738

  Fly   379 AELRRLRRENCLLKQRNELLE-------AESAELADRLVRGQVSRAEEEETSYAIQTELMQLRRS 436
            .....||.:|..|::..:.||       .|:...|:.|::.:::..       .:..|...|..:
Yeast   739 DHYESLRIQNHQLQREAQKLEHDYSILNKENISAANELIQNRLNME-------MLLDEKNDLINT 796

  Fly   437 YLEVSHQLENANEEVRGLSLRLQENNVSIDSNNSRQSSIDELCMKEEALKQRDEMVSCLLEELVK 501
            ..::..|:|   ||:|  ...|...:.|:...:.|:.....:....|.:::..::
Yeast   797 ITDIKSQIE---EEIR--KQNLPNPDASLPKADLREDLERTISRNNEVMRENGQL---------- 846

  Fly   502 VRQGLAESEDQIRNLKAKVEEL 523
                    |::|..|:|:::||
Yeast   847 --------EERITELQAEIDEL 860

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Evi5	NP_727526.2	TBC	113..320	CDD:214540	74/208 (36%)
Evi5	NP_727526.2	DUF4527	627..>731	CDD:291689
GYP5	NP_015075.1	COG5210	154..737	CDD:227535	110/387 (28%)
GYP5	NP_015075.1	SMC_prok_B	726..>891	CDD:274008	31/165 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	149	1.000	Domainoid score	I947
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	162	1.000	Inparanoid score	I1053
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000497
OrthoInspector	1	1.000	-	-		mtm9196
orthoMCL	1	0.900	-	-		OOG6_101755
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R541
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.890