DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Evi5 and GYL1

DIOPT Version :9

Sequence 1:	NP_727526.2	Gene:	Evi5 / 32088	FlyBaseID:	FBgn0262740	Length:	807	Species:	Drosophila melanogaster
Sequence 2:	NP_013917.1	Gene:	GYL1 / 855230	SGDID:	S000004804	Length:	720	Species:	Saccharomyces cerevisiae

Alignment Length:	521	Identity:	114/521 - (21%)
Similarity:	227/521 - (43%)	Gaps:	110/521 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 IESDAKSLNSLHSTHSRKNSDTSQISLTSSGNSVAEEDIWTTWATILNDWEGALKRKNPCVSELV 113
            ::.|:|.:|                      |:...|::.:.|..::.|::..|......:...:
Yeast   252 LKEDSKKIN----------------------NNEIPEEVSSFWLKVIGDYQNILINDIETLHFQL 294

  Fly   114 RRGIPHHFRAIVWQQLSGA-SDGDKKQYAEYIKATSACEKVIRRDIARTYPEVEFFKEKDGPGQE 177
            .||||..:|.:|||.:|.| |......|..|:      .::...|:.....:::...|......:
Yeast   295 SRGIPAAYRLVVWQLVSYAKSKSFDPIYETYL------TEMAPFDVQEFENQLKMMDEVPSEYVK 353

  Fly   178 ALFNVIKAYSLHDREVGYCQGSGFIVGLLLMQMPEE-EAFAVLVQIMQQHRMRHMFKPSMSELGL 241
            .:.||:|||.|.|.|..:.....:|:.::|....|| .||.:||::|:.:.:|.:|.||.||:.:
Yeast   354 RISNVLKAYLLFDPECEFSTDIAYIINMILDVCEEEANAFGLLVRLMKVYGLRLLFLPSASEIDI 418

  Fly   242 CMYQLENLVQEQIPDMHIHFQQQGFQTTMYASSWFLTLYTTTLNVNLSCRIMDVFLSEGMEFIFK 306
            ..|:.:.||:|..|::|.|..::|.:::|:...:|.||:...|...:..||.|:...||::.|.:
Yeast   419 LCYKFDRLVEEFYPEIHNHMVEKGVRSSMFLPGFFTTLFQKKLPTEIQPRIGDMVFLEGIDSIMR 483

  Fly   307 VALALLLTGKDTLLCLDMEAMLKFFQKELPGRVEADVE------GFFNLA------------YSI 353
            :...||...:|.||.:..:.||:..:.   |.::|.::      |...|:            ..:
Yeast   484 ILATLLSNSRDHLLKMGFDDMLELLKS---GLLDAYIKQNDGTRGDTLLSNECMDKLLQDSMMKV 545

  Fly   354 KLNTKRMKKMEKEYQDLKKKEQEEMAELRRLRRENCLLKQRNELLEAESAELADRLVRGQVSRAE 418
            .:..|.|||...||:::.:.:.|:..:.:.:..:|..|::                   .|.:.|
Yeast   546 AITPKTMKKYSSEYEEIHRLDNEKEVQYKSITEKNLHLQK-------------------HVRKLE 591

  Fly   419 EEETSYAIQTELMQLRRSYLEVSHQL-------ENANEEVRGLSLRLQENNVSIDSNNSRQ---- 472
            .:.||         |.|.::.::::|       |:...|..|..|::.:....:||...:|
Yeast   592 NDYTS---------LNREHVTIANELVKNRLNIESVLNENNGYKLQILDLKKKLDSEKKKQVLGV 647

  Fly   473 ----SSIDELCMKEEALKQRDEMVSCLLEELVKVRQGLAESEDQIRNLKAKVEELEEDKK--TLR 531
                ....:|   ||.:|:..:    :::|.:|:       :|:|..|:..:||::...|  ||.
Yeast   648 YVPNDLKKDL---EETMKKNTQ----VMDENLKL-------QDRISELERLIEEIKTANKNGTLF 698

  Fly   532 E 532
            |
Yeast   699 E 699

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Evi5	NP_727526.2	TBC	113..320	CDD:214540	60/208 (29%)
Evi5	NP_727526.2	DUF4527	627..>731	CDD:291689
GYL1	NP_013917.1	COG5210	27..569	CDD:227535	82/347 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	162	1.000	Inparanoid score	I1053
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000497
OrthoInspector	1	1.000	-	-		mtm9196
orthoMCL	1	0.900	-	-		OOG6_101755
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.860