DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Evi5 and AT2G37290

DIOPT Version :9

Sequence 1:	NP_727526.2	Gene:	Evi5 / 32088	FlyBaseID:	FBgn0262740	Length:	807	Species:	Drosophila melanogaster
Sequence 2:	NP_001189697.1	Gene:	AT2G37290 / 818306	AraportID:	AT2G37290	Length:	916	Species:	Arabidopsis thaliana

Alignment Length:	847	Identity:	182/847 - (21%)
Similarity:	317/847 - (37%)	Gaps:	240/847 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 SSAESQAKMDVKG-----------GALPGEENLPTSEMDLLAKLEAANKLIESD-----AKSLNS 58
            |..|.:|:.:.|.           ..|...|::..|.:..:...:...|.|..|     .:||:|
plant   203 SGHEEKAQKETKAPRSVIEWAHIRPCLASIEDMMCSRVKNVKSTKNGQKNIVDDHASSIKESLSS 267

  Fly    59 L-HSTHSRKNSDTSQISLTSSGNSVAEEDIWTTWATILNDWEGALKRKN--PCVSE---LVRRGI 117
            : .|..:.::|:||    ||..:|:.||          |:.:|::..:.  |...|   |||.|:
plant   268 IEESGENDRDSETS----TSRSHSIKEE----------NEAQGSVSPEPFFPWYEELEVLVRLGV 318

  Fly   118 PHHFRAIVWQQLSGASDGDKKQYAEYIKA--TSACE----------KVIRRDIARTYPEVEFFKE 170
            |...|..|||...|......::|.:.:.|  |::.|          |.|.:||.||:|......|
plant   319 PKDLRGEVWQAFVGVKARRVERYYQDLLAQITNSDENSSDVQRKWKKQIEKDIPRTFPGHPALNE 383

  Fly   171 KDGPGQEALFNVIKAYSLHDREVGYCQGSGFIVGLLLMQMPEEEAFAVLVQIMQQHRMRHMFKPS 235
            .   |:::|..::.||:.|:..|||||...|..||||:.||||.||..||.|:..: ....:...
plant   384 N---GRDSLRRILLAYACHNPSVGYCQAMNFFAGLLLLLMPEENAFWTLVGIIDDY-FDGYYTEE 444

  Fly   236 MSELGLCMYQLENLVQEQIP------------DMHI----------------------HFQQQGF 266
            |.|..:.....|.|::|:.|            .:||                      |....|.
plant   445 MIESQVDQLVFEELMRERFPKLGSLFSSDIQVSLHIFLPYTEQCDRFFYSNNPPDAVNHLDYLGV 509

  Fly   267 QTTMYASSWFLTLYTTTLNVNLSCRIMDVFLSEGMEFI-FKVALALL-LTGK---------DTLL 320
            |....:..|||:::...:......|:.||.|.||...: |:.|.|:: |.|.         |.:.
plant   510 QVAWISGPWFLSIFVNIIPWECVLRMWDVLLFEGNRVVLFRTAFAIMELYGPAIVATKDAGDAIT 574

  Fly   321 CLDMEAMLKFFQKELPGRVEADVEGFFNLAYSIKLNTKRMKKMEKEYQDLKKKEQEEMAELRRLR 385
            .|...|...|...:|   |.....|:      |..|..|::                  |||::.
plant   575 SLQSLASSTFDSSQL---VLTACMGY------ISTNEARLE------------------ELRKIH 612

  Fly   386 RENCLLKQRNELLEAESAELADRLVRGQVSRAEEEETSYAIQTELMQLRRSYLEVSHQL------ 444
            |...|     |::|       :|:.:|:|.:.::     .:.::|...:.....:.|:.
plant   613 RPAVL-----EIVE-------ERIQKGRVWKDKK-----GLASKLYSFKHEGSILDHEQKSTQRN 660

  Fly   445 --ENANEEVRGLS--LRLQENNV--SIDSNNSRQSSI----DELCM----KEEALKQRDEMVSCL 495
              ||.:::....|  |.|...||  .:||....|..:    .|||.    |..|:.:.:|:...|
plant   661 DGENQDDDDESCSPFLNLDGANVDSEVDSLPDLQEQVVWMKVELCRLLEEKRSAVMRAEELEIAL 725

  Fly   496 LEELVKVRQGLAESEDQIRNLKAKVEELEEDKKTLRETTPDNSVAHLQDELIASKLREAEASLSL 560
            : |:||        ||....|.|::|:||.|.:.|::...|                :.|...::
plant   726 M-EMVK--------EDNRLELSARIEQLERDVRELKQVLSD----------------KKEQETAM 765

  Fly   561 KDLKQRVQELSSQWQRQLAENQRSESERTTNAVDSTPKKLLTNFFDSSKSSEHTQKLEEELMTTR 625
            ..:..:|::     .::|.|:.|..:|:...|               .:.:.|..:.:.|.:.|:
plant   766 LQVLMKVEQ-----DQKLTEDARINAEQDAAA---------------QRYAVHVLQEKNEKLVTQ 810

  Fly   626 IREMETLTELKELRLKVMELETQVQVSTNQLRRQDEEHKKLKEELEMAVTREKDMSNKAREQQHR 690
            :.:||     |:|......||..:|..:.|                          |||.....|
plant   811 LAQME-----KKLVTAETTLEATLQYESGQ--------------------------NKALSSSPR 844

  Fly   691 Y--SDLES-RMKDELMNVKIKFTEQSQTVAELKQEISRLETKNSEMLAEGELRANLDDSDKVRDL 752
            :  :..|| :.|...::..:.:.::::.....:..:.......||..:..:...||...:|..||
plant   845 FTRTTTESPKKKTGFLSFGLGWRDRNKAKQTEESNVDNTSNAASEAKSPSKESVNLSKENKSEDL 909

  Fly   753 QD 754
            .|
plant   910 LD 911

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Evi5	NP_727526.2	TBC	113..320	CDD:214540	71/263 (27%)
Evi5	NP_727526.2	DUF4527	627..>731	CDD:291689	15/106 (14%)
AT2G37290	NP_001189697.1	RabGAP-TBC	363..563	CDD:278964	57/203 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	113	1.000	Inparanoid score	I2045
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.960