DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Evi5 and tbc1d1

DIOPT Version :9

Sequence 1:	NP_727526.2	Gene:	Evi5 / 32088	FlyBaseID:	FBgn0262740	Length:	807	Species:	Drosophila melanogaster
Sequence 2:	XP_031751223.1	Gene:	tbc1d1 / 733547	XenbaseID:	XB-GENE-5959648	Length:	1286	Species:	Xenopus tropicalis

Alignment Length:	455	Identity:	127/455 - (27%)
Similarity:	225/455 - (49%)	Gaps:	40/455 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 LLAKLEAANKLIESDAKSLNSLHSTHSRKNSDTSQISLTSSGNSVAEEDIWTTWATILN-DWEGA 101
            ||.::|..|:.:::....|.     :.|...|..:|       :...:|:...|..:|: .....
Frog   848 LLLRMEKENQKLQASENDLQ-----NKRLKLDYEEI-------TPCLKDVTLVWEKMLSTPGRSK 900

  Fly   102 LKRKNPCVSELVRRGIPHHFRAIVWQQLS--------GASDGDKKQ--YAEYIKATSACEKVIRR 156
            :|.....:...|.:|:|...|..:|:.||        ..|....|.  |.|.:|..:..:..|..
Frog   901 IKTDTEKIHAAVGQGVPRQHRGEIWKFLSEQYQLRHQHISKNQLKDTPYKELLKQLTTQQHAILI 965

  Fly   157 DIARTYPEVEFFKEKDGPGQEALFNVIKAYSLHDREVGYCQGSGFIVGLLLMQMPEEEAFAVLVQ 221
            |:.||:|...:|..:.|.||.:|:|::|||||.|.|||||||..|:.|:||:.|.||:||.:|..
Frog   966 DLGRTFPTHPYFSAQLGAGQLSLYNILKAYSLLDPEVGYCQGLSFVAGVLLLHMTEEDAFKMLKF 1030

  Fly   222 IMQQHRMRHMFKPSMSELGLCMYQLENLVQEQIPDMHIHFQQQGFQTTMYASSWFLTLYTTTLNV 286
            :|....:|..::|.|..|.:.||||..|:.:...|::.|.:......::||:.||||::.:...:
Frog  1031 LMYDLGLRKQYRPDMITLQIQMYQLSRLLHDYHRDLYNHLETYEIGPSLYAAPWFLTMFASQFPL 1095

  Fly   287 NLSCRIMDVFLSEGMEFIFKVALALLLTGKDTLLCLD-MEAMLKFFQKELPGRVEADVEGFFNLA 350
            ....|:.|:...:|.|.||||||:||.:.|..:|..: :|::::|.:..||......:|...|..
Frog  1096 GFVARVFDMIFLQGSEVIFKVALSLLGSHKPLILQHENLESIVEFIKNTLPNLGLVQMEKTINQV 1160

  Fly   351 YSIKLNTKRMKKMEKEYQDLKKK--EQEEMAELRRLRRENCLLKQRNELLEAESAELADRLVRGQ 413
            :.:.: :|:::..|.||..|:.:  :...:::.:|:.:    |::.|..|..::.:|.:.|   |
Frog  1161 FEMDI-SKQLQAYEVEYHVLQDELIDSSPLSDNQRINK----LEKANSTLRKQNFDLLEEL---Q 1217

  Fly   414 VSRAE---EEETSYAIQTELMQLRRSYLEVSHQ---LENANEEVRGLSLRLQENNVSIDSNNSRQ 472
            ||...   .|.|...:|:..::|:||.|.:..:   |.|..||:|.....:|.|.:..|.|...|
Frog  1218 VSHGRIQVLESTVENLQSNEVKLKRSVLTLELERSALLNTIEELRAQIKDMQGNKLCNDQNEPNQ 1282

Fly 473 472
Frog 1283 1282

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Evi5	NP_727526.2	TBC	113..320	CDD:214540	77/216 (36%)
Evi5	NP_727526.2	DUF4527	627..>731	CDD:291689
tbc1d1	XP_031751223.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910