DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Evi5 and evi5

DIOPT Version :9

Sequence 1:	NP_727526.2	Gene:	Evi5 / 32088	FlyBaseID:	FBgn0262740	Length:	807	Species:	Drosophila melanogaster
Sequence 2:	XP_002933848.4	Gene:	evi5 / 733501	XenbaseID:	XB-GENE-983877	Length:	825	Species:	Xenopus tropicalis

Alignment Length:	777	Identity:	346/777 - (44%)
Similarity:	499/777 - (64%)	Gaps:	62/777 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 TLTTTTTASSAESQAKMDVKGGALPGEENLPTSEMDLLAKLEAANKLIESDAKSLNSLHSTHSRK 66
            |.::||.::.|.|.:.        |.|  |...:::||||||..|:|:|.|:|||.|::.  ||:
Frog    15 TSSSTTLSTPALSPSS--------PVE--LSPDDVELLAKLEEQNRLLEIDSKSLRSVNG--SRR 67

  Fly    67 NSDTSQISLTSSGNSVA---EEDIWTTWATILNDWEGALKRKNPCVSELVRRGIPHHFRAIVWQQ 128
            ||.:|.:|.:|:.::::   |||.|..|..|:|:||...|:|...:.||||:||||||||||||.
Frog    68 NSGSSLVSSSSASSNLSHHQEEDSWLLWGRIVNEWEEVYKKKEKQIKELVRKGIPHHFRAIVWQL 132

  Fly   129 LSGASDGD-KKQYAEYIKATSACEKVIRRDIARTYPEVEFFKEKDGPGQEALFNVIKAYSLHDRE 192
            |..|.:.. |.||.:.:|.||.|||:|||||||||||.:||||||..|||.||||:|||||.|||
Frog   133 LCNAQNMPIKDQYCDLLKMTSPCEKLIRRDIARTYPEHDFFKEKDSLGQEVLFNVMKAYSLVDRE 197

  Fly   193 VGYCQGSGFIVGLLLMQMPEEEAFAVLVQIMQQHRMRHMFKPSMSELGLCMYQLENLVQEQIPDM 257
            |||||||.||||||||||||||||.|.|::||.:|:|.:|||||:||||||||.|.::|||:|::
Frog   198 VGYCQGSAFIVGLLLMQMPEEEAFCVFVKLMQDYRLRELFKPSMAELGLCMYQFECMIQEQLPEL 262

  Fly   258 HIHFQQQGFQTTMYASSWFLTLYTTTLNVNLSCRIMDVFLSEGMEFIFKVALALLLTGKDTLLCL 322
            ::|||.|.|.|:|||||||||::.|:..:.::.||.|:|:|||:|.:|:..||:|...:..|:.|
Frog   263 YVHFQAQSFHTSMYASSWFLTIFLTSFPLPIATRIFDIFMSEGLEIVFRAGLAVLQMNQTELMQL 327

  Fly   323 DMEAMLKFFQKELPGRVEADVEGFFNLAYSIKLNTKRMKKMEKEYQDLKKKEQEEMAELRRLRRE 387
            |||.||:.|||.:|.:.:...:.....||.:|.|.|:|||:||||..:|.||.||..|::|||.|
Frog   328 DMEGMLQHFQKVIPHQFDGGPDKLIQAAYQVKYNAKKMKKLEKEYTTIKTKELEEQVEIKRLRTE 392

  Fly   388 NCLLKQRNELLEAESAELADRLVRGQVSRAEEEETSYAIQTELMQLRRSYLEVSHQLENANEEVR 452
            |.|||||.|.||.|||.|||||::|||:||:|.|.:|.|:.||..:::...|.|.:||.|:..:.
Frog   393 NRLLKQRIETLEKESASLADRLIQGQVTRAQEAEENYLIKRELATIKQQSDEASTKLEQAHHTIS 457

  Fly   453 GLSLRLQENNVSIDSNNSRQSSIDELCMKEEALKQRDEMVSCLLEELVKVRQGLAESEDQIRNLK 517
            .|     ::...:...|.|.|               :|.|..|..|||:.|...|||...::.::
Frog   458 EL-----QHQRELHKCNPRYS---------------EEFVLQLETELVQARLKEAESHCAMKEMQ 502

  Fly   518 AKVEELEEDKKTLRETTPDN-SVAHLQDELIASKLREAEASLSLKDLKQRVQELSSQWQRQLAEN 581
            .|:.|:|:...:|    ||. :|..||:||||.|||||||.::||::||:::.|...|||.||
Frog   503 DKILEIEKRNASL----PDEINVVRLQEELIAVKLREAEAVMALKEVKQQIKNLEEHWQRHLA-- 561

  Fly   582 QRSESERTTNAVDSTPKKLLTNFFDSSKSSEHTQKLEEELMTTRIREMETLTELKELRLKVMELE 646
                  ||.......|||...|            :|::||||.|:||.|...||:|:|.::||:|
Frog   562 ------RTAGRWKDPPKKNTIN------------ELQDELMTVRLREAERHAELREVRQRMMEME 608

  Fly   647 TQVQVSTNQLRRQDEEHKKLKEELEMAVTREKDMSNKAREQQHRYSDLESRMKDELMNVKIKFTE 711
            ||.|:::|||||.::|...|:.:::....:.|.:..:..|.:.:.:::|.:.|:|:|.|:::..:
Frog   609 TQNQINSNQLRRAEQEVSSLQSKVQYLTAQNKGLQAQLNEAKRKQAEIECKNKEEVMAVRLREAD 673

  Fly   712 QSQTVAELKQEISRLETKNSEMLAEGELRANLDDSDKVRDLQDRLADMKAELTALKSRGKFP 773
            ....||||:|.|:.||.:..|...:|:|. |.|.|..:|:|:|::.::|.|:..|||:...|
Frog   674 SIAAVAELQQHIAELEIQKEEGKIQGQLN-NSDSSQYIRELKDQIVELKHEIKCLKSQKGLP 734

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Evi5	NP_727526.2	TBC	113..320	CDD:214540	132/207 (64%)
Evi5	NP_727526.2	DUF4527	627..>731	CDD:291689	35/103 (34%)
evi5	XP_002933848.4	TBC	117..325	CDD:214540	132/207 (64%)
evi5	XP_002933848.4	Smc	<350..694	CDD:224117	146/387 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	280	1.000	Domainoid score	I1651
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H121902
Inparanoid	1	1.050	620	1.000	Inparanoid score	I866
OMA	1	1.010	-	-		QHG46583
OrthoDB	1	1.010	-	-		D191811at2759
OrthoFinder	1	1.000	-	-		FOG0000497
OrthoInspector	1	1.000	-	-		otm47950
Panther	1	1.100	-	-	LDO	PTHR22957
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1412
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.080